ZIFs-derived Co₃O₄ nanoparticles anchored on graphene for highly sensitive uric acid electrochemical sensors

Abstract

This paper describes an electrochemical sensor using the glassy carbon electrode modified with the Co₃O₄/graphene nanocomposite to detect uric acid (UA). The Co₃O₄/graphene nanocomposite was synthesized through a simple method by calcining cobalt-based zeolite imidazole framework (ZIF-12) doped with graphene and characterized through powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. Meanwhile, the electrochemical performance of the Co₃O₄/graphene nanocomposite was investigated by differential pulse voltammetry and cyclic voltammetry. This proposed sensor exhibits high selectivity, with a wide linear range within the UA concentration range of 0.05–50.0 µmol·L⁻¹. It also has an extremely low detection limit of 1.25×10⁻⁸ mol·L⁻¹, attributed to its good electron transfer efficiency.

Graphical abstract

Keywords

Co₃O₄/graphene composite / electrochemical sensor / uric acid

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