Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents

Abstract

Microorganisms coexist with human beings and have formed a complex relationship with us. However, the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents. Currently available antimicrobials, such as silver ions, antimicrobial peptides and antibiotics, have diverse concerns in chemical stability, biocompatibility, or triggering drug resistance. The “encapsulate-and-deliver” strategy can protect antimicrobials against decomposing, so to avoid large dose release induced resistance and achieve the controlled release. Considering loading capacity, engineering feasibility, and economic viability, inorganic hollow mesoporous spheres (iHMSs) represent one kind of promising and suitable candidates for real-life antimicrobial applications. Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery. We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials, and discussed the future applications. To prevent and mitigate the spread of an infective disease, multilateral coordination at the national level is required. Moreover, developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes. We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.

Graphical abstract

Keywords

antimicrobial / inorganic hollow mesoporous sphere / encapsulate-and-deliver / drug delivery

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Disclosure of potential conflicts of interests

The authors declare no conflict of interest.

Acknowledgements

This work was financially supported by the project ZR2020MB069 supported by the Shandong Provincial Natural Science Foundation. T.Z. thanks the generous funding support from the Shandong Provincial Natural Science Foundation (ZR2020QB163) and the Taishan Scholars Program of Shandong Province, China (No. tsqn201909083).

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