Nanotheranostics and its role in diagnosis, treatment and prevention of COVID-19

Abstract

Microbe-related, especially viral-related pandemics have currently paralyzed the world and such pathogenesis is expected to rise in the upcoming years. Although tremendous efforts are being made to develop antiviral drugs, very limited progress has been made in this direction. The nanotheranostic approach can be a highly potential rescue to combat this pandemic. Nanoparticles (NPs) due to their high specificity and biofunctionalization ability could be utilized efficiently for prophylaxis, diagnosis and treatment against microbial infections. In this context, titanium oxide, silver, gold NPs, etc. have already been utilized against deadly viruses like influenza, Ebola, HIV, and HBV. The discovery of sophisticated nanovaccines is under investigation and of prime importance to induce reproducible and strong immune responses against difficult pathogens. This review focuses on highlighting the role of various nano-domain materials such as metallic NPs, magnetic NPs, and quantum dots in the biomedical applications to combat the deadly microbial infections. Further, it also discusses the nanovaccines those are already available for various microbial diseases or are in clinical trials. Finally, it gives a perspective on the various nanotechnologies presently employed for efficient diagnosis and therapy against disease causing microbial infections, and how advancement in this field can benefit the health sector remarkably.

Graphical abstract

Keywords

nanotheranostics / nanovaccine / antimicrobial / antiviral / SARS-CoV-2

References

[1] Siafaka P I, Okur N Ü, Karantas I D, , . Current update on nanoplatforms as therapeutic and diagnostic tools: a review for the materials used as nanotheranostics and imaging modalities. Asian Journal of Pharmaceutical Sciences, 2021, 16( 1): 24– 46

[2] Muthu M S, Leong D T, Mei L, , . Nanotheranostics — application and further development of nanomedicine strategies for advanced theranostics. Theranostics, 2014, 4( 6): 660– 677

[3] Mendes M, Sousa J J, Pais A, , . Targeted theranostic nanoparticles for brain tumor treatment. Pharmaceutics, 2018, 10( 4): 181

[4] Rai M, Razzagh-Abyaneh M, Ingle A P, eds. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment. Wiley, 2020

[5] Caster J M, Patel A N, Zhang T, , . Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017, 9( 1): e1416

[6] Kirtane A R, Verma M, Karandikar P, , . Nanotechnology approaches for global infectious diseases. Nature Nanotechnology, 2021, 16( 4): 369– 384

[7] Siafaka P I, Okur N U, Karavas E, , . Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses. International Journal of Molecular Sciences, 2016, 17( 9): 1440

[8] Roy A, Gauri S S, Bhattacharya M, , . Antimicrobial activity of CaO nanoparticles. Journal of Biomedical Nanotechnology, 2013, 9( 9): 1570– 1578

[9] Baptista P V, McCusker M P, Carvalho A, , . Nano-strategies to fight multidrug resistant bacteria — “A Battle of the Titans”. Frontiers in Microbiology, 2018, 9 : 1441

[10] Dos Santos Ramos M A, Da Silva P B, Spósito L, , . Nanotechnology-based drug delivery systems for control of microbial biofilms: a review. International Journal of Nanomedicine, 2018, 13 : 1179– 1213

[11] Rai M, Ingle A P, Gaikwad S, , . Nanotechnology based anti-infectives to fight microbial intrusions. Journal of Applied Microbiology, 2016, 120( 3): 527– 542

[12] Sharma M, Dube T, Chibh S, , . Nanotheranostics, a future remedy of neurological disorders. Expert Opinion on Drug Delivery, 2019, 16( 2): 113– 128

[13] Shanker R, Singh G, Jyoti A, , . Nanotechnology and detection of microbial pathogens. In: Animal Biotechnology. Elsevier, 2014, 525– 540

[14] Dube T, Ghosh A, Mishra J, , . Repurposed drugs, molecular vaccines, immune-modulators, and nanotherapeutics to treat and prevent COVID-19 associated with SARS-CoV-2, a deadly nanovector. Advanced Therapeutics, 2021, 4( 2): 2000172

[15] Das B S, Das A, Mishra A, , . Microbial cells as biological factory for nanoparticle synthesis. Frontiers of Materials Science, 2021, 15( 2): 177– 191

[16] Panda S, Yadav K K, Nayak P S, , . Screening of metal-resistant coal mine bacteria for biofabrication of elemental silver nanoparticle. Bulletin of Materials Science, 2016, 39( 2): 397– 404

[17] Sharma M, Nayak P S, Asthana S, , . Biofabrication of silver nanoparticles using bacteria from mangrove swamp. IET Nanobiotechnology, 2018, 12( 5): 626– 632

[18] Grippin A J, Wummer B, Wildes T, , . Dendritic cell-activating magnetic nanoparticles enable early prediction of antitumor response with magnetic resonance imaging. ACS Nano, 2019, 13( 12): 13884– 13898

[19] Yadavalli T, Shukla D . Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections. Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13( 1): 219– 230

[20] Palmieri V, Papi M . Can graphene take part in the fight against COVID-19?. Nano Today, 2020, 33 : 100883

[21] Shin M D, Shukla S, Chung Y H, , . COVID-19 vaccine development and a potential nanomaterial path forward. Nature Nanotechnology, 2020, 15( 8): 646– 655

[22] Mc Carthy D J, Malhotra M, O’Mahony A M, , . Nanoparticles and the blood–brain barrier: advancing from in-vitro models towards therapeutic significance. Pharmaceutical Research, 2015, 32( 4): 1161– 1185

[23] Dollo G, Boucaud Y, Amela-Cortes M, , . PLGA nanoparticles embedding molybdenum cluster salts: influence of chemical composition on physico-chemical properties, encapsulation efficiencies, colloidal stabilities and in vitro release. International Journal of Pharmaceutics, 2020, 576 : 119025

[24] Pandey N, Menon J U, Takahashi M, , . Thermo-responsive fluorescent nanoparticles for multimodal imaging and treatment of cancers. Nanotheranostics, 2020, 4( 1): 1– 13

[25] Martinez-Gutierrez F, Olive P L, Banuelos A, , . Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine, 2010, 6( 5): 681– 688

[26] Lipovsky A, Nitzan Y, Gedanken A, , . Antifungal activity of ZnO nanoparticles — the role of ROS mediated cell injury. Nanotechnology, 2011, 22( 10): 105101

[27] Arakha M, Pal S, Samantarrai D, , . Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface. Scientific Reports, 2015, 5( 1): 14813

[28] Khizar S, Ahmad N M, Zine N, , . Magnetic nanoparticles: from synthesis to theranostic applications. ACS Applied Nano Materials, 2021, 4( 5): 4284– 4306

[29] Chouhan R S, Horvat M, Ahmed J, , . Magnetic nanoparticles — a multifunctional potential agent for diagnosis and therapy. Cancers, 2021, 13( 9): 2213

[30] Cotta M A . Quantum dots and their applications: what lies ahead?. ACS Applied Nano Materials, 2020, 3( 6): 4920– 4924

[31] Valizadeh A, Mikaeili H, Samiei M, , . Quantum dots: synthesis, bioapplications, and toxicity. Nanoscale Research Letters, 2012, 7( 1): 480

[32] Arakha M, Saleem M, Mallick B C, , . The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle. Scientific Reports, 2015, 5( 1): 9578

[33] Nakane J, Wiggin M, Marziali A . A nanosensor for transmembrane capture and identification of single nucleic acid molecules. Biophysical Journal, 2004, 87( 1): 615– 621

[34] Nayak P S, Pradhan S, Arakha M, , . Silver nanoparticles fabricated using medicinal plant extracts show enhanced antimicrobial and selective cytotoxic propensities. IET Nanobiotechnology, 2019, 13( 2): 193– 201

[35] Nayak P S, Arakha M, Kumar A, , . An approach towards continuous production of silver nanoparticles using Bacillus thuringiensis. RSC Advances, 2016, 6( 10): 8232– 8242

[36] Arakha M, Borah S M, Saleem M, , . Interfacial assembly at silver nanoparticle enhances the antibacterial efficacy of nisin. Free Radical Biology & Medicine, 2016, 101 : 434– 445

[37] Liu L, Xu K, Wang H, , . Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. Nature Nanotechnology, 2009, 4( 7): 457– 463

[38] Zhu X, Radovic-Moreno A F, Wu J, , . Nanomedicine in the management of microbial infection — overview and perspectives. Nano Today, 2014, 9( 4): 478– 498

[39] Singh A . Eliciting B cell immunity against infectious diseases using nanovaccines. Nature Nanotechnology, 2021, 16( 1): 16– 24

[40] Xu F, Xia Q, Wang P . Rationally designed DNA nanostructures for drug delivery. Frontiers in Chemistry, 2020, 8 : 751

[41] Wang Y, Dai L, Ding Z, , . DNA origami single crystals with Wulff shapes. Nature Communications, 2021, 12( 1): 3011

[42] Zhao X, Zhang S . Fabrication of molecular materials using peptide construction motifs. Trends in Biotechnology, 2004, 22( 9): 470– 476

[43] Hong S, Choi D W, Kim H N, , . Protein-based nanoparticles as drug delivery systems. Pharmaceutics, 2020, 12( 7): 604

[44] Madani S Y, Shabani F, Dwek M V, , . Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment. International Journal of Nanomedicine, 2013, 8 : 941– 950

[45] Sung J H, Han D, Lee J B . Self-assembled DNA-based giant thrombin nanoparticles for controlled release. Biotechnology Journal, 2013, 8( 2): 215– 220

[46] Zhang H, Yee D, Wang C . Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives. Nanomedicine, 2008, 3( 1): 83– 91

[47] Zheng M, Ruan S, Liu S, , . Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano, 2015, 9( 11): 11455– 11461

[48] Chaudhary V, Royal A, Chavali M, , . Advancements in research and development to combat COVID-19 using nanotechnology. Nanotechnology for Environmental Engineering, 2021, 6( 1): 8

[49] Martinez J P, Sasse F, Brönstrup M, , . Antiviral drug discovery: broad-spectrum drugs from nature. Natural Product Reports, 2015, 32( 1): 29– 48

[50] Saravanan M, Mostafavi E, Vincent S, , . Nanotechnology-based approaches for emerging and re-emerging viruses: special emphasis on COVID-19. Microbial Pathogenesis, 2021, 156 : 104908

[51] Zhang W, Huang L, Ye G, , . Vaccine booster efficiently inhibits entry of SARS-CoV-2 Omicron variant. Cellular & Molecular Immunology, 2022, 19( 3): 445– 446

[52] Wang Y, Zhang L, Li Q, , . The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron. Emerging Microbes & Infections, 2022, 11( 1): 1– 5

[53] Fouad G I . A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19). Bulletin of the National Research Center, 2021, 45( 1): 36

[54] Lee N Y, Ko W C, Hsueh P R . Nanoparticles in the treatment of infections caused by multidrug-resistant organisms. Frontiers in Pharmacology, 2019, 10 : 1153

[55] Mosselhy D A, Assad M A, Sironen T, , . Could nanotheranostics be the answer to the coronavirus crisis?. Global Challenges, 2021, 5( 6): 2000112

[56] Gruell H, Vanshylla K, Tober-Lau P, , . mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant. Nature Medicine, 2022, 28( 3): 477– 480

[57] Dejnirattisai W, Huo J, Zhou D, , . SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell, 2022, 185( 3): 467

[58] Planas D, Saunders N, Maes P, , . Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Nature, 2022, 602( 7898): 671– 675

[59] Christensen P A, Olsen R J, Long S W, , . Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with coronavirus disease 2019 caused by the omicron variant of severe acute respiratory syndrome coronavirus 2 in houston, Texas. The American Journal of Pathology, 2022, 192( 4): 642– 652

[60] Yetisgin A A, Cetinel S, Zuvin M, , . Therapeutic nanoparticles and their targeted delivery applications. Molecules, 2020, 25( 9): 2193

[61] Parodi A, Molinaro R, Sushnitha M, , . Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery. Biomaterials, 2017, 147 : 155– 168

[62] Dey S, Fan C, Gothelf K V, , . DNA origami. Nature Reviews Methods Primers, 2021, 1( 1): 13

[63] Li D, Tao L, Shen Y, , . Fabrication of multilayered nanofiber scaffolds with a highly aligned nanofiber yarn for anisotropic tissue regeneration. ACS Omega, 2020, 5( 38): 24340– 24350

[64] Marradi M, Chiodo F, García I, , . Glyconanoparticles as multifunctional and multimodal carbohydrate systems. Chemical Society Reviews, 2013, 42( 11): 4728– 4745

[65] Eatemadi A, Daraee H, Karimkhanloo H, , . Carbon nanotubes: properties, synthesis, purification, and medical applications. Nanoscale Research Letters, 2014, 9( 1): 393

[66] Chibh S, Katoch V, Kour A, , . Continuous flow fabrication of Fmoc-cysteine based nanobowl infused core‒shell like microstructures for pH switchable on-demand anti-cancer drug delivery. Biomaterials Science, 2021, 9( 3): 942– 959

[67] Chibh S, Kour A, Yadav N, , . Redox-responsive dipeptide nanostructures toward targeted cancer therapy. ACS Omega, 2020, 5( 7): 3365– 3375

[68] Abbasi E, Aval S F, Akbarzadeh A, , . Dendrimers: synthesis, applications, and properties. Nanoscale Research Letters, 2014, 9( 1): 247

[69] Bharti C, Nagaich U, Pal A K, , . Mesoporous silica nanoparticles in target drug delivery system: a review. International Journal of Pharmaceutical Investigation, 2015, 5( 3): 124– 133

[70] Mukherjee S, Ray S, Thakur R S . Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian Journal of Pharmaceutical Sciences, 2009, 71( 4): 349– 358

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