Preparation of green cellulose diacetate-based antibacterial wound dressings for wound healing

Abstract

Managing wounds is a growing universal problem and developing effective wound dressings to staunch bleeding and protect wounds from bacterial infections is an increasingly serious challenge. In this work, a remolding electrospinning nanofiber three-dimensional structure wound dressing (CCP) was prepared with superhydrophilicity, high water absorption and absorbing capacity, excellent hemostatic capacity and antibacterial ability, and biocompatibility to promote wound healing. Polyhexamethylene guanidine hydrochloride (PHMG) was grafted to cellulose diacetate (CDA) wound dressing surface through an amide reaction. A water contact angle analysis demonstrated that CCP wound dressing could be beneficial to promote wound exudate management effectively with rapid absorption of water within 0.2 s. In vitro hemo- and cytocompatibility assay showed that a CCP wound dressing had no significant hemotoxicity or cytoxicity. Specifically, CCP wound dressings could be beneficial to accelerate wound hemostasis and further reduce mortality caused by uncontrolled bleeding. Furthermore, CCP wound dressings have an excellent antibacterial ability, which could be beneficial to inhibit wound inflammatory over-reaction and promote normal wound healing. Combined together, the prepared wound dressing in this research effort is expected to have high-potential in clinical applications.

Graphical abstract

Keywords

cellulose diacetate / electrospinning / antibacterial performance / hemostasis / wound dressing

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Ethical statement

All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of Shanghai Jiao Tong University and approved by the Animal Ethics Committee of Renji Hospital Affiliated to Tongji University.

Authors’ contributions

Chuang Xiao: writing, original draft, and investigation; Ge Zhang: investigation; Wencheng Liang: supervision and writing (review & editing); Zhaochuang Wang: software; Qiaohui Lu: investigation; Wenbin Shi: conceptualization; Yan Zhou: conceptualization; Yong Guan: conceptualization and methodology; Meidong Lang: supervision and writing (review & editing).

Disclosure of potential conflict of interest

The authors declare no conflict of interest.

Acknowledgements

This research was supported by the National Key Research and Development Program (2016YFC1100703).

RIGHTS & PERMISSIONS

2022 Higher Education Press