Bibliometric landscape of the researches on protein corona of nanoparticles

Abstract

Unclear biological fate hampers the clinical translation of nanoparticles for biomedical uses. In recent years, it is documented that the formation of protein corona upon nanoparticles is a critical factor leading to the ambiguous biological fate. Efforts have been made to explore the protein corona forming behaviors on nanoparticles, and rearrangement of the relevant studies will help to understand the current trend of such a topic. In this work, the publications about protein corona of nanoparticles in Science Citation Index Expanded database of Web of Science from 2007 to 2020 (1417 in total) were analyzed in detail, and the bibliometrics landscape of them was showcased. The basic bibliometrics characteristics were summarized to provide an overall understanding. Citation analysis was performed to scrutinize the peer interests of these papers. The research hotspots in the field were evaluated, based on which some feasible topics for future studies were proposed. In general, the results demonstrated that protein corona of nanoparticles was a prospective research area, and had attracted global research interests. It was believed that this work could comprehensively highlight the bibliometrics landscape, inspire further exploitation on protein corona of nanoparticles, and ultimately promote the clinical translation of nanoparticles.

Graphical abstract

Keywords

protein corona / nanoparticle / bibliometrics / Web of Science

References

[1] Flauraud V, Mastrangeli M, Bernasconi G D, . Nanoscale topographical control of capillary assembly of nanoparticles. Nature Nanotechnology, 2017, 12(1): 73–80

[2] Pavlov R V, Gaynanova G A, Kuznetsova D A, . Biomedical potentialities of cationic geminis as modulating agents of liposome in drug delivery across biological barriers and cellular uptake. International Journal of Pharmaceutics, 2020, 587: 119640

[3] He H, Xie Y, Lv Y, . Bioimaging of intact polycaprolactone nanoparticles using aggregation-caused quenching probes: Size-dependent translocation via oral delivery. Advanced Healthcare Materials, 2018, 7(22): 1800711

[4] Li Y, Chen W, Qi Y, . H₂S-scavenged and activated iron oxide-hydroxide nanospindles for MRI-guided photothermal therapy and ferroptosis in colon cancer. Small, 2020, 16(37): 2001356

[5] Wang S, Li F, Qiao R, . Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics. ACS Nano, 2018, 12(12): 12380–12392

[6] Zelepukin I V, Popov A A, Shipunova V O, . Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science and Engineering C, 2021, 120: 111717

[7] Huang L, Chen J, He M, . Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin. Chinese Chemical Letters, 2019, 30(1): 163–166

[8] Zoya I, He H, Wang L, . The intragastrointestinal fate of paclitaxel-loaded micelles: Implications on oral drug delivery. Chinese Chemical Letters, 2021, 32(4): 1545–1549

[9] Totten J D, Wongpinyochit T, Seib F P. Silk nanoparticles: Proof of lysosomotropic anticancer drug delivery at single-cell resolution. Journal of Drug Targeting, 2017, 25(9–10): 865–872

[10] Patiño-Herrera R, Louvier-Hernández J F, Escamilla-Silva E M, . Prolonged release of metformin by SiO₂ nanoparticles pellets for type II diabetes control. European Journal of Pharmaceutical Sciences, 2019, 131: 1–8

[11] Li Y, Lim E, Fields T, . Improving sensitivity and specificity of amyloid-β peptides and tau protein detection with antibiofouling magnetic nanoparticles for liquid biopsy of Alzheimer’s disease. ACS Biomaterials Science & Engineering, 2019, 5(7): 3595–3605

[12] D’Mello S R, Cruz C N, Chen M L, . The evolving landscape of drug products containing nanomaterials in the United States. Nature Nanotechnology, 2017, 12(6): 523–529

[13] Qi J, Hu X, Dong X, . Towards more accurate bioimaging of drug nanocarriers: Turning aggregation-caused quenching into a useful tool. Advanced Drug Delivery Reviews, 2019, 143: 206–225

[14] Tosi G, Musumeci T, Ruozi B, . The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood–brain barrier crossing and trafficking into the central nervous system. Journal of Drug Delivery Science and Technology, 2016, 32: 66–76

[15] Chen D, Ganesh S, Wang W, . Protein corona-enabled systemic delivery and targeting of nanoparticles. The AAPS Journal, 2020, 22(4): 83

[16] Mekseriwattana W, Srisuk S, Kriangsaksri R, . The impact of serum proteins and surface chemistry on magnetic nanoparticle colloidal stability and cellular uptake in breast cancer cells. AAPS PharmSciTech, 2019, 20(2): 55

[17] Srivastav A K, Dhiman N, Khan H, . Impact of surface-engineered ZnO nanoparticles on protein corona configuration and their interactions with biological system. Journal of Pharmaceutical Sciences, 2019, 108(5): 1872–1889

[18] Yu J, Choi S J. Particle size and biological fate of ZnO do not cause acute toxicity, but affect toxicokinetics and gene expression profiles in the rat livers after oral administration. International Journal of Molecular Sciences, 2021, 22(4): 1698

[19] Quagliarini E, Di Santo R, Palchetti S, . Effect of protein corona on the transfection efficiency of lipid-coated graphene oxide-based cell transfection reagents. Pharmaceutics, 2020, 12(2): 113

[20] Guo M, Zhao L, Liu J, . The underlying function and structural organization of the intracellular protein corona on graphdiyne oxide nanosheet for local immunomodulation. Nano Letters, 2021, 21(14): 6005–6013

[21] Lu X, Xu P, Ding H M, . Tailoring the component of protein corona via simple chemistry. Nature Communications, 2019, 10(1): 4520

[22] Yang Q, Wang M, Sun Y, . Pre-incubated with BSA-complexed free fatty acids alters ER stress/autophagic gene expression by carboxylated multi-walled carbon nanotube exposure in THP-1 macrophages. Chinese Chemical Letters, 2019, 30(6): 1224–1228

[23] Berrecoso G, Crecente-Campo J, Alonso M J. Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers. Drug Delivery and Translational Research, 2020, 10(3): 730–750

[24] Bertrand N, Grenier P, Mahmoudi M, . Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics. Nature Communications, 2017, 8(1): 777

[25] Coreas R, Cao X, DeLoid G M, . Lipid and protein corona of food-grade TiO₂ nanoparticles in simulated gastrointestinal digestion. NanoImpact, 2020, 20: 100272

[26] Salatin S, Maleki Dizaj S, Yari Khosroushahi A. Effect of the surface modification, size, and shape on cellular uptake of nanoparticles. Cell Biology International, 2015, 39(8): 881–890

[27] Ban Z, Yuan P, Yu F, . Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(19): 10492–10499

[28] Escamilla-Rivera V, Uribe-Ramírez M, González-Pozos S, . Protein corona acts as a protective shield against Fe₃O₄-PEG inflammation and ROS-induced toxicity in human macrophages. Toxicology Letters, 2016, 240(1): 172–184

[29] Gunawan C, Lim M, Marquis C P, . Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2014, 2(15): 2060–2083

[30] Abstiens K, Maslanka Figueroa S, Gregoritza M, . Interaction of functionalized nanoparticles with serum proteins and its impact on colloidal stability and cargo leaching. Soft Matter, 2019, 15(4): 709–720

[31] Cedervall T, Lynch I, Lindman S, . Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(7): 2050–2055

[32] Caracciolo G. Liposome-protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines. Nanomedicine, 2015, 11(3): 543–557

[33] Obst K, Yealland G, Balzus B, . Protein corona formation on colloidal polymeric nanoparticles and polymeric nanogels: Impact on cellular uptake, toxicity, immunogenicity, and drug release properties. Biomacromolecules, 2017, 18(6): 1762–1771

[34] Wu R, Peng H, Zhu J J, . Attaching DNA to gold nanoparticles with a protein corona. Frontiers in Chemistry, 2020, 8: 121

[35] Givens B E, Wilson E, Fiegel J. The effect of salts in aqueous media on the formation of the BSA corona on SiO₂ nanoparticles. Colloids and Surfaces B: Biointerfaces, 2019, 179: 374–381

[36] Hajipour M J, Raheb J, Akhavan O, . Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide. Nanoscale, 2015, 7(19): 8978–8994

[37] Mo J, Xu Y, Wang X, . Exploiting the protein corona: Coating of black phosphorus nanosheets enables macrophage polarization via calcium influx. Nanoscale, 2020, 12(3): 1742–1748

[38] Perng W, Palui G, Wang W, . Elucidating the role of surface coating in the promotion or prevention of protein corona around quantum dots. Bioconjugate Chemistry, 2019, 30(9): 2469–2480

[39] Lynch I, Cedervall T, Lundqvist M, . The nanoparticle–protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Advances in Colloid and Interface Science, 2007, 134–135: 167–174

[40] Hafeez D M, Jalal S, Khosa F. Bibliometric analysis of manuscript characteristics that influence citations: A comparison of six major psychiatry journals. Journal of Psychiatric Research, 2019, 108: 90–94

[41] Yu Y, Li Y, Zhang Z, . A bibliometric analysis using VOSviewer of publications on COVID-19. Annals of Translational Medicine, 2020, 8(13): 816

[42] Zhang T, Yin X, Yang X, . Research trends on the relationship between Microbiota and Gastric Cancer: A Bibliometric Analysis from 2000 to 2019. Journal of Cancer, 2020, 11(16): 4823–4831

[43] Liu Q, Ye Y. A study on mining bibliographic records by designed software SATI: Case study on library and information science. Journal of Information Resources Management, 2012, 2(1): 50–58 (in Chinese)

[44] Zhou S, Tao Z, Zhu Y, . Mapping theme trends and recognizing hot spots in postmenopausal osteoporosis research: A bibliometric analysis. PeerJ, 2019, 7: e8145

[45] Lynch I, Salvati A, Dawson K A. Protein–nanoparticle interactions: What does the cell see? Nature Nanotechnology, 2009, 4(9): 546–547

[46] Röcker C, Pötzl M, Zhang F, . A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles. Nature Nanotechnology, 2009, 4(9): 577–580

[47] Digiacomo L, Pozzi D, Palchetti S, . Impact of the protein corona on nanomaterial immune response and targeting ability. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, 12(4): e1615

[48] Lima T, Bernfur K, Vilanova M, . Understanding the lipid and protein corona formation on different sized polymeric nanoparticles. Scientific Reports, 2020, 10(1): 1129

[49] Lundqvist M, Stigler J, Elia G, . Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(38): 14265–14270

[50] Monopoli M P, Aberg C, Salvati A, . Biomolecular coronas provide the biological identity of nanosized materials. Nature Nanotechnology, 2012, 7(12): 779–786

[51] Tenzer S, Docter D, Kuharev J, . Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nature Nanotechnology, 2013, 8(10): 772–781

[52] Monopoli M P, Walczyk D, Campbell A, . Physical–chemical aspects of protein corona: Relevance to in vitro and in vivo biological impacts of nanoparticles. Journal of the American Chemical Society, 2011, 133(8): 2525–2534

[53] Nel A E, Mädler L, Velegol D, . Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials, 2009, 8(7): 543–557

[54] Walkey C D, Chan W C. Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. Chemical Society Reviews, 2012, 41(7): 2780–2799

[55] Lesniak A, Fenaroli F, Monopoli M P, . Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells. ACS Nano, 2012, 6(7): 5845–5857

[56] Salvati A, Pitek A S, Monopoli M P, . Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nature Nanotechnology, 2013, 8(2): 137–143

[57] Walczyk D, Bombelli F B, Monopoli M P, . What the cell “sees” in bionanoscience. Journal of the American Chemical Society, 2010, 132(16): 5761–5768

[58] Boyack K W, Klavans R. Co-citation analysis, bibliographic coupling, and direct citation: Which citation approach represents the research front most accurately? Journal of the American Society for Information Science and Technology, 2010, 61(12): 2389–2404

[59] Wang B, Xing D, Zhu Y, . The state of exosomes research: A global visualized analysis. BioMed Research International, 2019, 2019: 1495130

[60] Fan Y, Chen H, Huang Z, . Taste-masking and colloidal-stable cubosomes loaded with Cefpodoxime proxetil for pediatric oral delivery. International Journal of Pharmaceutics, 2020, 575: 118875

[61] Dal Magro R, Albertini B, Beretta S, . Artificial apolipoprotein corona enables nanoparticle brain targeting. Nanomedicine, 2018, 14(2): 429–438

RIGHTS & PERMISSIONS

Higher Education Press