Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: A review

Abstract

The design and development of multifunctional nano-drug delivery systems (NDDSs) is a solution that is expected to solve some intractable problems in traditional cancer treatment. In particular, metal-organic frameworks (MOFs) are novel hybrid porous nanomaterials which are constructed by the coordination of metal cations or clusters and organic bridging ligands. Benefiting from their intrinsic superior properties, MOFs have captivated intensive attentions in drug release and cancer theranostic. Based on what has been achieved about MOF-based DDSs in recent years, this review introduces different stimuli-responsive mechanisms of them and their applications in cancer diagnosis and treatment systematically. Moreover, the existing challenges and future opportunities in this field are summarized. By realizing industrial production and paying attention to biosafety, their clinical applications will be enriched.

Graphical abstract

Keywords

metal-organic framework / nanomaterial / stimuli-responsiveness / cancer theranostic

References

[1] He H, Xie H, Chen Y, . Global, regional, and national burdens of bladder cancer in 2017: Estimates from the 2017 global burden of disease study. BMC Public Health, 2020, 20(1): 1693

[2] Sung H, Ferlay J, Siegel R L, . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2021, 71(3): 209–249

[3] Zhang M, Ma Y, Wang Z, . A CD44-targeting programmable drug delivery system for enhancing and sensitizing chemotherapy to drug-resistant cancer. ACS Applied Materials & Interfaces, 2019, 11(6): 5851–5861

[4] Kumar A, Jaitak V. Natural products as multidrug resistance modulators in cancer. European Journal of Medicinal Chemistry, 2019, 176: 268–291

[5] Obayemi J D, Salifu A A, Eluu S C, . LHRH-conjugated drugs as targeted therapeutic agents for the specific targeting and localized treatment of triple negative breast cancer. Scientific Reports, 2020, 10(1): 8212

[6] Mittra I, Pal K, Pancholi N, . Prevention of chemotherapy toxicity by agents that neutralize or degrade cell-free chromatin. Annals of Oncology, 2017, 28(9): 2119–2127

[7] Ding Y, Ma Y, Du C, . NO-releasing polypeptide nanocomposites reverse cancer multidrug resistance via triple therapies. Acta Biomaterialia, 2021, 123: 335–345

[8] Mi P. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics, 2020, 10(10): 4557–4588

[9] Raj S, Khurana S, Choudhari R, . Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Seminars in Cancer Biology, 2021, 69: 166–177

[10] Liu H, Jiang W, Wang Q, . ROS-sensitive biomimetic nanocarriers modulate tumor hypoxia for synergistic photodynamic chemotherapy. Biomaterials Science, 2019, 7(9): 3706–3716

[11] Pandey A, Kulkarni S, Vincent A P, . Hyaluronic acid-drug conjugate modified core–shell MOFs as pH responsive nanoplatform for multimodal therapy of glioblastoma. International Journal of Pharmaceutics, 2020, 588: 119735

[12] Sanfilippo V, Caruso V C L, Cucci L M, . Hyaluronan-metal gold nanoparticle hybrids for targeted tumor cell therapy. International Journal of Molecular Sciences, 2020, 21(9): 3085–3111

[13] Chen J, Ma Y, Du W, . Furin-instructed intracellular gold nanoparticle aggregation for tumor photothermal therapy. Advanced Functional Materials, 2020, 30(50): 2001566

[14] Kong M, Huang Y, Yu R, . Coordination bonding-based Fe₃O₄@PDA-Zn²⁺-doxorubicin nanoparticles for tumor chemo-photothermal therapy. Journal of Drug Delivery Science and Technology, 2019, 51: 185–193

[15] Wen W, Wu L, Chen Y, . Ultra-small Fe₃O₄ nanoparticles for nuclei targeting drug delivery and photothermal therapy. Journal of Drug Delivery Science and Technology, 2020, 58: 101782

[16] Guan Y, Yang Y, Wang X, . Multifunctional Fe₃O₄@SiO₂-CDs magnetic fluorescent nanoparticles as effective carrier of gambogic acid for inhibiting VX2 tumor cells. Journal of Molecular Liquids, 2021, 327: 114783

[17] Huang L, Liu J, Gao F, . A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2018, 6(28): 4618–4629

[18] Shao M, Chang C, Liu Z, . Polydopamine coated hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for overcoming multidrug resistance. Colloids and Surfaces B: Biointerfaces, 2019, 183: 110427

[19] Chen K, Chang C, Liu Z, . Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy. Colloids and Surfaces B: Biointerfaces, 2020, 194: 111166

[20] Saleem J, Wang L, Chen C. Carbon-based nanomaterials for cancer therapy via targeting tumor microenvironment. Advanced Healthcare Materials, 2018, 7(20): 1800525

[21] Loh K P, Ho D, Chiu G N C, . Clinical applications of carbon nanomaterials in diagnostics and therapy. Advanced Materials, 2018, 30(47): 1802368

[22] Jiang B P, Zhou B, Lin Z, . Recent advances in carbon nanomaterials for cancer phototherapy. Chemistry, 2019, 25(16): 3993–4004

[23] Zhao S, Cao W, Xing S, . Enhancing effects of theanine liposomes as chemotherapeutic agents for tumor therapy. ACS Biomaterials Science & Engineering, 2019, 5(7): 3373–3379

[24] Zhang K, Zhang Y, Meng X, . Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy. Biomaterials, 2018, 185: 301–309

[25] Yang Y, Liu X, Ma W, . Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy. Biomaterials, 2021, 265: 120456

[26] Yang L, Zhang C, Liu J, . ICG-conjugated and ¹²⁵I-labeled polymeric micelles with high biosafety for multimodality imaging-guided photothermal therapy of tumors. Advanced Healthcare Materials, 2020, 9(5): 1901616

[27] Hu C, Zhuang W, Yu T, . Multi-stimuli responsive polymeric prodrug micelles for combined chemotherapy and photodynamic therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2020, 8(24): 5267–5279

[28] Zhong S, Chen C, Yang G, . Acid-triggered nanoexpansion polymeric micelles for enhanced photodynamic therapy. ACS Applied Materials & Interfaces, 2019, 11(37): 33697–33705

[29] Li X, Zhang Y, Zhi X, . Analysis of clinical efficacy of nano-albumin paclitaxel treatment for advanced cell lung cancer. Journal of Nanoscience and Nanotechnology, 2020, 20(10): 6019–6025

[30] Zhou Y, Chang C, Liu Z, . Hyaluronic acid-functionalized hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for cancer chemo-photodynamic therapy. Langmuir, 2021, 37(8): 2619–2628

[31] Zhang L, Shi X, Zhang Z, . Porphyrinic zirconium metal-organic frameworks (MOFs) as heterogeneous photocatalysts for PET-RAFT polymerization and stereolithography. Angewandte Chemie International Edition, 2021, 60(10): 5489–5496

[32] Gulcay E, Erucar I. Biocompatible MOFs for storage and separation of O₂: A molecular simulation study. Industrial & Engineering Chemistry Research, 2019, 58(8): 3225–3237

[33] Daglar H, Gulbalkan H C, Avci G, . Effect of metal-organic framework (MOF) database selection on the assessment of gas storage and separation potentials of MOFs. Angewandte Chemie International Edition, 2021, 60(14): 7828–7837

[34] Hao M, Qiu M, Yang H, . Recent advances on preparation and environmental applications of MOF-derived carbons in catalysis. Science of the Total Environment, 2021, 760: 143333

[35] Neufeld M J, Winter H, Landry M R, . Lanthanide metal-organic frameworks for multispectral radioluminescent imaging. ACS Applied Materials & Interfaces, 2020, 12(24): 26943–26954

[36] Gao X, Cui R, Ji G, . Size and surface controllable metal-organic frameworks (MOFs) for fluorescence imaging and cancer therapy. Nanoscale, 2018, 10(13): 6205–6211

[37] Kumar P, Anand B, Tsang Y F, . Regeneration, degradation, and toxicity effect of MOFs: Opportunities and challenges. Environmental Research, 2019, 176: 108488

[38] Schnabel J, Ettlinger R, Bunzen H. Zn-MOF-74 as pH-responsive drug-delivery system of arsenic trioxide. Chem-NanoMat, 2020, 6(8): 1229–1236

[39] Liu Z, Li T, Han F, . A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF. Biomaterials Science, 2019, 7(9): 3683–3692

[40] Xiao Y, Xu M, Lv N, . Dual stimuli-responsive metal-organic framework-based nanosystem for synergistic photothermal/pharmacological antibacterial therapy. Acta Biomaterialia, 2021, 122: 291–305

[41] Liang S, Xiao X, Bai L, . Conferring Ti-based MOFs with defects for enhanced sonodynamic cancer therapy. Advanced Materials, 2021, 33(18): 2100333

[42] Sun Q, Bi H, Wang Z, . Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy. Biomaterials, 2019, 223: 119473

[43] Jiang Z, Wang T, Yuan S, . A tumor-sensitive biological metal-organic complex for drug delivery and cancer therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2020, 8(32): 7189–7196

[44] Pan W, Shi M, Li Y, . A GSH-responsive nanophotosensitizer for efficient photodynamic therapy. RSC Advances, 2018, 8(74): 42374–42379

[45] Yu L Y, Shen Y A, Chen M H, . The feasibility of ROS- and GSH-responsive micelles for treating tumor-initiating and metastatic cancer stem cells. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2019, 7(19): 3109–3118

[46] Sameiyan E, Bagheri E, Dehghani S, . Aptamer-based ATP-responsive delivery systems for cancer diagnosis and treatment. Acta Biomaterialia, 2021, 123: 110–122

[47] Yuwen L, Qiu Q, Xiu W, . Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal/photodynamic therapy of methicillin-resistant Staphylococcus aureus infections. Biomaterials Science, 2021, 9(12): 4484–4495

[48] Zhang N, Li M, Sun X, . NIR-responsive cancer cytomembrane-cloaked carrier-free nanosystems for highly efficient and self-targeted tumor drug delivery. Biomaterials, 2018, 159: 25–36

[49] Ding Y, Du C, Qian J, . NIR-responsive polypeptide nanocomposite generates NO gas, mild photothermia, and chemotherapy to reverse multidrug-resistant cancer. Nano Letters, 2019, 19(7): 4362–4370

[50] Zhang W, Lu J, Gao X, . Enhanced photodynamic therapy by reduced levels of intracellular glutathione obtained by employing a nano-MOF with Cu(II) as the active center. Angewandte Chemie International Edition, 2018, 57(18): 4891–4896

[51] Sabz M, Kamali R, Ahmadizade S. Numerical simulation of magnetic drug targeting to a tumor in the simplified model of the human lung. Computer Methods and Programs in Biomedicine, 2019, 172: 11–24

[52] Shen S, Huang D, Cao J, . Magnetic liposomes for light-sensitive drug delivery and combined photothermal-chemotherapy of tumors. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2019, 7(7): 1096–1106

[53] Nguyen Cao T G, Kang J H, You J Y, . Safe and targeted sonodynamic cancer therapy using biocompatible exosome-based nanosonosensitizers. ACS Applied Materials & Interfaces, 2021, 13(22): 25575–25588

[54] Mathesh M, Sun J, van der Sandt F, . Supramolecular nanomotors with “pH taxis” for active drug delivery in the tumor microenvironment. Nanoscale, 2020, 12(44): 22495–22501

[55] Yan T, Zhu S, Hui W, . Chitosan based pH-responsive polymeric prodrug vector for enhanced tumor targeted co-delivery of doxorubicin and siRNA. Carbohydrate Polymers, 2020, 250: 116781

[56] Lázaro I A, Haddad S, Sacca S, . Selective surface PEGylation of UiO-66 nanoparticles for enhanced stability, cell uptake, and pH-responsive drug delivery. Chem, 2017, 2(4): 561–578

[57] Jiang K, Zhang L, Hu Q, . Indocyanine green-encapsulated nanoscale metal-organic frameworks for highly effective chemo-photothermal combination cancer therapy. Materials Today Nano, 2018, 2: 50–57

[58] Yu S, Wang S, Xie Z, . Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study. Colloids and Surfaces B: Biointerfaces, 2021, 203: 111759

[59] Qin Y T, Peng H, He X W, . pH-responsive polymer-stabilized ZIF-8 nanocomposites for fluorescence and magnetic resonance dual-modal imaging-guided chemo-/photodynamic combinational cancer therapy. ACS Applied Materials & Interfaces, 2019, 11(37): 34268–34281

[60] Zhu J, Li H, Xiong Z, . Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Applied Materials & Interfaces, 2018, 10(41): 34954–34964

[61] Liu Z, Shen N, Tang Z, . An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy. Biomaterials Science, 2019, 7(7): 2803–2811

[62] Lin C, He H, Zhang Y, . Acetaldehyde-modified-cystine functionalized Zr-MOFs for pH/GSH dual-responsive drug delivery and selective visualization of GSH in living cells. RSC Advances, 2020, 10(6): 3084–3091

[63] Li J, Wang Y, Sun S, . Disulfide bond-based self-crosslinked carbon-dots for turn-on fluorescence imaging of GSH in living cells. The Analyst, 2020, 145(8): 2982–2987

[64] Lei B, Wang M, Jiang Z, . Constructing redox-responsive metal-organic framework nanocarriers for anticancer drug delivery. ACS Applied Materials & Interfaces, 2018, 10(19): 16698–16706

[65] Liu Y, Gong C S, Dai Y, . In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery. Biomaterials, 2019, 218: 119365–119375

[66] Deng J, Wang K, Wang M, . Mitochondria targeted nanoscale zeolitic imidazole framework-90 for ATP imaging in live cells. Journal of the American Chemical Society, 2017, 139(16): 5877–5882

[67] Song X R, Li S H, Dai J, . Polyphenol-inspired facile construction of smart assemblies for ATP- and pH-responsive tumor MR/Optical imaging and photothermal therapy. Small, 2017, 13(20): 1603997

[68] Chen W H, Yu X, Cecconello A, . Stimuli-responsive nucleic acid-functionalized metal-organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks. Chemical Science, 2017, 8(8): 5769–5780

[69] Chen W H, Liao W C, Sohn Y S, . Stimuli-responsive nucleic acid-based polyacrylamide hydrogel-coated metal-organic framework nanoparticles for controlled drug release. Advanced Functional Materials, 2018, 28(8): 1705137

[70] Wan S S, Zhang L, Zhang X Z. An ATP-regulated ion transport nanosystem for homeostatic perturbation therapy and sensitizing photodynamic therapy by autophagy inhibition of tumors. ACS Central Science, 2019, 5(2): 327–340

[71] Zuo W, Chen D, Fan Z, . Design of light/ROS cascade-responsive tumor-recognizing nanotheranostics for spatiotemporally controlled drug release in locoregional photo-chemotherapy. Acta Biomaterialia, 2020, 111: 327–340

[72] Lv W, Xia H, Zou L, . Yolk–shell structured Au nanorods@mesoporous silica for gas bubble driven drug release upon near-infrared light irradiation. Nanomedicine: Nanotechnology, Biology, and Medicine, 2021, 32: 102326

[73] Zhu X, Su Q, Feng W, . Anti-Stokes shift luminescent materials for bio-applications. Chemical Society Reviews, 2017, 46(4): 1025–1039

[74] Xu J, Gulzar A, Liu Y, . Integration of IR-808 sensitized upconversion nanostructure and MoS₂ nanosheet for 808 nm NIR light triggered phototherapy and bioimaging. Small, 2017, 13(36): 17018141

[75] Lismont M, Dreesen L, Wuttke S. Metal-organic framework nanoparticles in photodynamic therapy: Current status and perspectives. Advanced Functional Materials, 2017, 27(14): 1606314

[76] Park J, Jiang Q, Feng D, . Size-controlled synthesis of porphyrinic metal-organic framework and functionalization for targeted photodynamic therapy. Journal of the American Chemical Society, 2016, 138(10): 3518–3525

[77] Liu J, Yang Y, Zhu W, . Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment. Biomaterials, 2016, 97: 1–9

[78] Li B, Wang X, Chen L, . Ultrathin Cu-TCPP MOF nanosheets: A new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers. Theranostics, 2018, 8(15): 4086–4096

[79] Wang Y, Shi L, Ma D, . Tumor-activated and metal-organic framework assisted self-assembly of organic photosensitizers. ACS Nano, 2020, 14(10): 13056–13068

[80] Yang D, Xu J, Yang G, . Metal-organic frameworks join hands to create an anti-cancer nanoplatform based on 808 nm light driving up-conversion nanoparticles. Chemical Engineering Journal, 2018, 344: 363–374

[81] Huang J, Xu Z, Jiang Y, . Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy. Journal of Nanobiotechnology, 2021, 19(1): 219

[82] Cai X, Xie Z, Ding B, . Monodispersed copper(I)-based nano metal-organic framework as a biodegradable drug carrier with enhanced photodynamic therapy efficacy. Advanced Science, 2019, 6(15): 1900848

[83] Cai X, Jiang Y, Lin M, . Ultrasound-responsive materials for drug/gene delivery. Frontiers in Pharmacology, 2020, 10: 1650

[84] Cui X, Han X, Yu L, . Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine. Nano Today, 2019, 28: 100773

[85] Ibrahim M, Sabouni R, Husseini G A, . Facile ultrasound-triggered release of calcein and doxorubicin from iron-based metal-organic frameworks. Journal of Biomedical Nanotechno-logy, 2020, 16(9): 1359–1369

[86] Zhou Y, Wang M, Dai Z. The molecular design of and challenges relating to sensitizers for cancer sonodynamic therapy. Materials Chemistry Frontiers, 2020, 4(8): 2223–2234

[87] Huang C, Ding S, Jiang W, . Glutathione-depleting nanoplatelets for enhanced sonodynamic cancer therapy. Nano-scale, 2021, 13(8): 4512–4518

[88] Pan X, Wang W, Huang Z, . MOF-derived double-layer hollow nanoparticles with oxygen generation ability for multimodal imaging-guided sonodynamic therapy. Angewandte Chemie International Edition, 2020, 59(32): 13557–13561

[89] Ke X, Song X, Qin N, . Rational synthesis of magnetic Fe₃O₄@MOF nanoparticles for sustained drug delivery. Journal of Porous Materials, 2019, 26(3): 813–818

[90] Aghayi-Anaraki M, Safarifard V. Fe₃O₄@MOF magnetic nanocomposites: Synthesis and applications. European Journal of Inorganic Chemistry, 2020, 2020(20): 1916–1937

[91] Xiang Z, Qi Y, Lu Y, . MOF-derived novel porous Fe₃O₄@C nanocomposites as smart nanomedical platforms for combined cancer therapy: Magnetic-triggered synergistic hyperthermia and chemotherapy. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2020, 8(37): 8671–8683

[92] Lin R, Yu W, Chen X, . Self-propelled micro/nanomotors for tumor targeting delivery and therapy. Advanced Healthcare Materials, 2021, 10(1): 2001212

[93] Xu J, Lee S S, Seo H, . Quinic acid-conjugated nanoparticles enhance drug delivery to solid tumors via interactions with endothelial selectins. Small, 2018, 14(50): 1803601

[94] Park J, Choi Y, Chang H, . Alliance with EPR effect: Combined strategies to improve the EPR effect in the tumor microenvironment. Theranostics, 2019, 9(26): 8073–8090

[95] Xue T, Xu C, Wang Y, . Doxorubicin-loaded nanoscale metal-organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy. Biomaterials Science, 2019, 7(11): 4615–4623

[96] Liu P, Zhou Y, Shi X, . A cyclic nano-reactor achieving enhanced photodynamic tumor therapy by reversing multiple resistances. Journal of Nanobiotechnology, 2021, 19(1): 149

[97] Yan J, Liu C, Wu Q, . Mineralization of pH-sensitive doxorubicin prodrug in ZIF-8 to enable targeted delivery to solid tumors. Analytical Chemistry, 2020, 92(16): 11453–11461

[98] Xu W, Lou Y, Chen W, . Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma. Biomedical Engineerin/Biomedizinische Technik, 2020, 65(2): 229–236

[99] Samui A, Pal K, Karmakar P, . In situ synthesized lactobionic acid conjugated NMOFs, a smart material for imaging and targeted drug delivery in hepatocellular carcinoma. Materials Science and Engineering C, 2019, 98: 772–781

[100] Zhang H, Zhang Q, Liu C, . Preparation of a one-dimensional nanorod/metal organic framework Janus nanoplatform via side-specific growth for synergistic cancer therapy. Biomaterials Science, 2019, 7(4): 1696–1704

[101] He Y, Xiong T, He S, . Pulmonary targeting crosslinked cyclodextrin metal-organic frameworks for lung cancer therapy. Advanced Functional Materials, 2021, 31(3): 2004550

[102] Zhang Y, Lin L, Liu L, . Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy. Biomaterials, 2019, 216: 119255–119263

[103] Kim K, Lee S, Jin E, . MOF × biopolymer: Collaborative combination of metal-organic framework and biopolymer for advanced anticancer therapy. ACS Applied Materials & Interfaces, 2019, 11(31): 27512–27520

[104] Wu M, Liu X, Bai H, . Surface-layer protein-enhanced immunotherapy based on cell membrane-coated nanoparticles for the effective inhibition of tumor growth and metastasis. ACS Applied Materials & Interfaces, 2019, 11(10): 9850–9859

[105] Chai Z, Hu X, Lu W. Cell membrane-coated nanoparticles for tumor-targeted drug delivery. Science China Materials, 2017, 60(6): 504–510

[106] Wan X, Song L, Pan W, . Tumor-targeted cascade nanoreactor based on metal-organic frameworks for synergistic ferroptosis-starvation anticancer therapy. ACS Nano, 2020, 14(9): 11017–11028

[107] Owens E A, Henary M, El Fakhri G, . Tissue-specific near-infrared fluorescence imaging. Accounts of Chemical Research, 2016, 49(9): 1731–1740

[108] Liu J, Liu Z, Wu D. Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy. International Journal of Nanomedicine, 2019, 14: 707–719

[109] Sun J, Wang J, Hu W, . Camouflaged gold nanodendrites enable synergistic photodynamic therapy and NIR biowindow II photothermal therapy and multimodal imaging. ACS Applied Materials & Interfaces, 2021, 13(9): 10778–10795

[110] Ouyang Z, Li D, Xiong Z, . Antifouling dendrimer-entrapped copper sulfide nanoparticles enable photoacoustic imaging-guided targeted combination therapy of tumors and tumor metastasis. ACS Applied Materials & Interfaces, 2021, 13(5): 6069–6080

[111] Zhou G, Wang Y S, Jin Z, . Porphyrin-palladium hydride MOF nanoparticles for tumor-targeting photoacoustic imaging-guided hydrogenothermal cancer therapy. Nanoscale Horizons, 2019, 4(5): 1185–1193

[112] Wang Y, Wu W, Mao D, . Metal-organic framework assisted and tumor microenvironment modulated synergistic image-guided photo-chemo therapy. Advanced Functional Materials, 2020, 30(28): 2002431

[113] Chen Y, Li Z H, Pan P, . Tumor-microenvironment-triggered ion exchange of a metal-organic framework hybrid for multimodal imaging and synergistic therapy of tumors. Advanced Materials, 2020, 32(24): 2001452

[114] Peller M, Böll K, Zimpel A, . Metal-organic framework nanoparticles for magnetic resonance imaging. Inorganic Che-mistry Frontiers, 2018, 5(8): 1760–1779

[115] McLeod S M, Robison L, Parigi G, . Maximizing magnetic resonance contrast in Gd(III) nanoconjugates: Investigation of proton relaxation in zirconium metal-organic frameworks. ACS Applied Materials & Interfaces, 2020, 12(37): 41157–41166

[116] Yao J, Liu Y, Wang J, . On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation. Biomaterials, 2019, 195: 51–62

[117] Ebrahimpour A, Riahi Alam N, Abdolmaleki P, . Magnetic metal-organic framework based on zinc and 5-aminolevulinic acid: MR imaging and brain tumor therapy. Journal of Inorganic and Organometallic Polymers and Materials, 2021, 31(3): 1208–1216

[118] Zhou H, Qi M, Shao J, . Manganese oxide/metal-organic frameworks-based nanocomposites for tumr micro-environment sensitive ¹H/¹⁹F dual-mode magnetic resonance imaging in vivo. Journal of Organometallic Chemistry, 2021, 933: 121652

[119] Guo C, Xu S, Arshad A, . A pH-responsive nanoprobe for turn-on ¹⁹F-magnetic resonance imaging. Chemical Communications, 2018, 54(70): 9853–9856

[120] Zhu W, Chen M, Liu Y, . A dual factor activated metal-organic framework hybrid nanoplatform for photoacoustic imaging and synergetic photo-chemotherapy. Nanoscale, 2019, 11(43): 20630–20637

[121] Pu Y, Zhu Y, Qiao Z, . A Gd-doped polydopamine (PDA)-based theranostic nanoplatform as a strong MR/PA dual-modal imaging agent for PTT/PDT synergistic therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2021, 9(7): 1846–1857

[122] Wan S S, Cheng Q, Zeng X, . A Mn(III)-sealed metal-organic framework nanosystem for redox-unlocked tumor theranostics. ACS Nano, 2019, 13(6): 6561–6571

[123] Zhu Y, Xin N, Qiao Z, . Bioactive MOFs based theranostic agent for highly effective combination of multimodal imaging and chemo-phototherapy. Advanced Healthcare Materials, 2020, 9(14): 2000205

[124] Cai W, Gao H, Chu C, . Engineering phototheranostic nanoscale metal-organic frameworks for multimodal imaging-guided cancer therapy. ACS Applied Materials & Interfaces, 2017, 9(3): 2040–2051

[125] Sun X, He G, Xiong C, . One-pot fabrication of hollow porphyrinic MOF nanoparticles with ultrahigh drug loading toward controlled delivery and synergistic cancer therapy. ACS Applied Materials & Interfaces, 2021, 13(3): 3679–3693

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