Electrospinning: An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing

Abstract

A chronic wound in diabetic patients is a major public health concern with socioeconomic and clinical manifestations. The underlying medical condition of diabetic patients deteriorates the wound through physiological, metabolic, molecular, and cellular pathologies. Consequently, a wound enters a vicious pathological inflammatory cycle. Many therapeutic approaches are in practice to manage diabetic wounds hence ensuring the regeneration process. Polymer-based biomaterials have come up with high therapeutic promises. Many efforts have been devoted, over the years, to build an effective wound healing material using polymers. The electrospinning technique, although not new, has turned out to be one of the most effective strategies in building wound healing biomaterials due to the special structural advantages of electrospun nanofibers over the other formulations. In this review, careful integration of all electrospinning approaches has been presented which will not only give an insight into the current updates but also be helpful in the development of new therapeutic material considering pathophysiological conditions of a diabetic wound.

Keywords

diabetic wound healing / inflammation / polymers / bioactive substances / hydrogel / electrospinning / nanofibers

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Disclosure of potential conflicts of interest

The authors declare that they have no conflict of interest.

Acknowledgements

This research was supported by the Fundamental Research Funds for the Central Universities (Grant No. 2232019A3-07), the National Key Research Program of China (2016YFA0201702 of 2016YFA0201700), the National Natural Science Foundation of China (Grant No. 31771023), and the Science and Technology Commission of Shanghai Municipality (Grant No. 19441902600).

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