A review on graphene-based materials as versatile cancer biomarker sensors

Shalmali BASU , Kamalika SEN

Front. Mater. Sci. ›› 2020, Vol. 14 ›› Issue (4) : 353 -372.

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Front. Mater. Sci. ›› 2020, Vol. 14 ›› Issue (4) : 353 -372. DOI: 10.1007/s11706-020-0530-8
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REVIEW ARTICLE

A review on graphene-based materials as versatile cancer biomarker sensors

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Abstract

Early detection of cancer has multitude of advantages like early diagnosis, reduced risk, ease in the treatment and follow up of recurrence. New and developed techniques are always under research to control the spreading malignancy. Graphene is an emerging star in biomedical field as it exhibits exceptional thermal, electrical and optical properties. Here, we review application of graphene-based materials in developing biosensing devices for the detection of different cancer biomarkers at concentrations down to sub-toxic levels. Different analytical methodologies chosen for sensing have been undertaken and their performance and background have been discussed. The trend of use of these methodologies can also be perceived from the graphical data presented.

Keywords

graphene / cancer biomarker / biosensing / analytical methods

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Shalmali BASU, Kamalika SEN. A review on graphene-based materials as versatile cancer biomarker sensors. Front. Mater. Sci., 2020, 14(4): 353-372 DOI:10.1007/s11706-020-0530-8

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References

[1]

Akinwande D, Brennan C J, Bunch J S, . A review on mechanics and mechanical properties of 2D materials — Graphene and beyond. Extreme Mechanics Letters, 2017, 13: 42–77

[2]

Soldano C, Mahmood A, Dujardin E. Production, properties and potential of graphene. Carbon, 2010, 48(8): 2127–2150

[3]

Shareena T P D, McShan D, Dasmahapatra A K, . A review on graphene-based nanomaterials in biomedical applications and risks in environment and health. Nano-Micro Letters, 2018, 10(3): 53

[4]

Cobas E, Friedman A L, Van’t Erve O M, . Graphene as a tunnel barrier: graphene-based magnetic tunnel junctions. Nano Letters, 2012, 12(6): 3000–3004

[5]

Chen Z, Ren W, Gao L, . Three-dimensional flexible and conductive interconnected graphene networks grown by chemical vapour deposition. Nature Materials, 2011, 10(6): 424–428

[6]

Loh K P, Bao Q, Ang P K, . The chemistry of graphene. Journal of Materials Chemistry, 2010, 20(12): 2277–2289

[7]

Tsoukleri G, Parthenios J, Papagelis K, . Subjecting a graphene monolayer to tension and compression. Small, 2009, 5(21): 2397–2402

[8]

Eftekhari A, Jafarkhani P. Curly graphene with specious interlayers displaying superior capacity for hydrogen storage. The Journal of Physical Chemistry C, 2013, 117(48): 25845–25851

[9]

Pop E, Varshney V, Roy A K. Thermal properties of graphene: Fundamentals and applications. MRS Bulletin, 2012, 37(12): 1273–1281

[10]

Castro Neto A H, Guinea F, Peres N M R, . The electronic properties of graphene. Reviews of Modern Physics, 2009, 81(1): 109–162

[11]

Chen J H, Jang C, Xiao S, . Intrinsic and extrinsic performance limits of graphene devices on SiO2. Nature Nanotechnology, 2008, 3(4): 206–209

[12]

Bunch J S. Mechanical and Electrical Properties of Graphene Sheets. Ithaca, NY: Cornell University, 2008

[13]

Bao Q, Loh K P. Graphene photonics, plasmonics, and broadband optoelectronic devices. ACS Nano, 2012, 6(5): 3677–3694

[14]

Plutnar J, Pumera M, Sofer Z. The chemistry of CVD graphene. Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 2018, 6(23): 6082–6101

[15]

Shu H, Tao X M, Ding F. What are the active carbon species during graphene chemical vapor deposition growth? Nanoscale, 2015, 7(5): 1627–1634

[16]

Jin Z, McNicholas T P, Shih C J, . Click chemistry on solution-dispersed graphene and monolayer CVD graphene. Chemistry of Materials, 2011, 23(14): 3362–3370

[17]

Park S, Ruoff R S. Chemical methods for the production of graphenes. Nature Nanotechnology, 2009, 4(4): 217–224

[18]

Withers F, Bointon T H, Craciun M F, . All-graphene photodetectors. ACS Nano, 2013, 7(6): 5052–5057

[19]

Fowler J D, Allen M J, Tung V C, . Practical chemical sensors from chemically derived graphene. ACS Nano, 2009, 3(2): 301–306

[20]

Zhu S E, Shabani R, Rho J, . Graphene-based bimorph microactuators. Nano Letters, 2011, 11(3): 977–981

[21]

Wu L, Qu X. Cancer biomarker detection: recent achievements and challenges. Chemical Society Reviews, 2015, 44(10): 2963–2997

[22]

Wang B, Akiba U, Anzai J I. Recent progress in nanomaterial-based electrochemical biosensors for cancer biomarkers: A review. Molecules, 2017, 22(7): 1048

[23]

Malhotra B D, Kumar S, Pandey C M. Nanomaterials based biosensors for cancer biomarker detection. Journal of Physics Conference Series, 2016, 704: 012011

[24]

Pasinszki T, Krebsz M, Tung T T, . Carbon nanomaterial based biosensors for non-invasive detection of cancer and disease biomarkers for clinical diagnosis. Sensors, 2017, 17(8): 1919

[25]

Rauf S, Mishra G K, Azhar J, . Carboxylic group riched graphene oxide based disposable electrochemical immunosensor for cancer biomarker detection. Analytical Biochemistry, 2018, 545: 13–19

[26]

Yadegari A, Omidi M, Yazdian F, . An electrochemical cytosensor for ultrasensitive detection of cancer cells using modified graphene–gold nanostructures. RSC Advances, 2017, 7(4): 2365–2372

[27]

Ravalli A, Voccia D, Palchetti I, . Electrochemical, electrochemiluminescence, and photoelectrochemical aptamer-based nanostructured sensors for biomarker analysis. Biosensors, 2016, 6(3): 39

[28]

Kumar V, Srivastava S, Umrao S, . Nanostructured palladium-reduced graphene oxide platform for high sensitive, label free detection of a cancer biomarker. RSC Advances, 2014, 4(5): 2267–2273

[29]

Gazze A, Ademefun R, Conlan R S, . Electrochemical impedence spectroscopy enabled CA125 detection; toward early ovarian cancer diagnosis using graphene biosensors. Journal of Interdisciplinary Nanomedicine, 2018, 3(2): 82–88

[30]

Dong W, Ren Y, Bai Z, . Trimetallic AuPtPd nanocomposites platform on graphene: Applied to electrochemical detection and breast cancer diagnosis. Talanta, 2018, 189: 79–85

[31]

Ali M A, Mondal K, Jiao Y, . Microfluidic immuno-biochip for detection of breast cancer biomarkers using hierarchical composite of porous graphene and titanium dioxide nanofibers. ACS Applied Materials & Interfaces, 2016, 8(32): 20570–20582

[32]

Hassanpour S, Hasanzadeh M, Saadati A, . A novel paper based immunoassay of breast cancer specific carbohydrate (CA 15.3) using silver nanoparticles-reduced graphene oxide nano-ink technology: A new platform to construction of microfluidic paper-based analytical devices (μPADs) towards biomedical analysis. Microchemical Journal, 2019, 146: 345–358

[33]

Gugoasa L A, AĺOgaidi A J M, Stefan-van Staden R I, . Multimode microsensors based on Ag–TiO2–graphene materials used for the molecular recognition of carcinoembryonic antigen in whole blood samples. RSC Advances, 2017, 7(45): 28419–28426

[34]

Wang Y, Luo J, Liu J, . Label-free microfluidic paper-based electrochemical aptasensor for ultrasensitive and simultaneous multiplexed detection of cancer biomarkers. Biosensors & Bioelectronics, 2019, 136: 84–90

[35]

Ali M A, Tabassum S, Wang Q, . Integrated dual-modality microfluidic sensor for biomarker detection using lithographic plasmonic crystal. Lab on a Chip, 2018, 18(5): 803–817

[36]

Abdurhman A A M, Zhang Y, Zhang G, . Hierarchical nanostructured noble metal/metal oxide/graphene-coated carbon fiber: in situ electrochemical synthesis and use as microelectrode for real-time molecular detection of cancer cells. Analytical and Bioanalytical Chemistry, 2015, 407(26): 8129–8136

[37]

Zhang Y, Xiao J, Lv Q, . In situ electrochemical sensing and real-time monitoring live cells based on freestanding nanohybrid paper electrode assembled from 3D functionalized graphene framework. ACS Applied Materials & Interfaces, 2017, 9(44): 38201–38210

[38]

Li C, Qiu X, Deng K, . Electrochemical co-reduction synthesis of Au/ferrocene–graphene nanocomposites and their application in an electrochemical immunosensor of a breast cancer biomarker. Analytical Methods, 2014, 6(22): 9078–9084

[39]

Saeed A A, Sánchez J L A, O’Sullivan C K, . DNA biosensors based on gold nanoparticles-modified graphene oxide for the detection of breast cancer biomarkers for early diagnosis. Bioelectrochemistry, 2017, 118: 91–99

[40]

Gao Y S, Zhu X F, Yang T T, . Sensitive electrochemical determination of α-fetoprotein using a glassy carbon electrode modified with in-situ grown gold nanoparticles, graphene oxide and MWCNTs acting as signal amplifiers. Microchimica Acta, 2015, 182(11–12): 2027–2035

[41]

Chen H, Zhang B, Cui Y, . One-step electrochemical immunoassay of biomarker based on nanogold-functionalized graphene sensing platform. Analytical Methods, 2011, 3(7): 1615–1621

[42]

Li H, Qin J, Li M, . Gold-nanoparticle-decorated boron-doped graphene/BDD electrode for tumor marker sensor. Sensors and Actuators B: Chemical, 2020, 302: 127209

[43]

Chen X, Jia X, Han J, . Electrochemical immunosensor for simultaneous detection of multiplex cancer biomarkers based on graphene nanocomposites. Biosensors & Bioelectronics, 2013, 50: 356–361

[44]

Zhang Q, Zhao Q, Fu M, . Carbon quantum dots encapsulated in super small platinum nanocrystals core–shell architecture/nitrogen doped graphene hybrid nanocomposite for electrochemical biosensing of DNA damage biomarker-8-hydroxy-2′-deoxyguanosine. Analytica Chimica Acta, 2019, 1047: 9–20

[45]

Amani J, Khoshroo A, Rahimi-Nasrabadi M. Electrochemical immunosensor for the breast cancer marker CA 15-3 based on the catalytic activity of a CuS/reduced graphene oxide nanocomposite towards the electrooxidation of catechol. Microchimica Acta, 2018, 185(1): 79

[46]

Rostamabadi P F, Heydari-Bafrooei E. Impedimetric aptasensing of the breast cancer biomarker HER2 using a glassy carbon electrode modified with gold nanoparticles in a composite consisting of electrochemically reduced graphene oxide and single-walled carbon nanotubes. Microchimica Acta, 2019, 186(8): 495

[47]

Rajaji U, Muthumariyappan A, Chen S M, . A novel electrochemical sensor for the detection of oxidative stress and cancer biomarker (4-nitroquinoline N-oxide) based on iron nitride nanoparticles with multilayer reduced graphene nanosheets modified electrode. Sensors and Actuators B: Chemical, 2019, 291: 120–129

[48]

Sharafeldin M, Bishop G W, Bhakta S, . Fe3O4 nanoparticles on graphene oxide sheets for isolation and ultrasensitive amperometric detection of cancer biomarker proteins. Biosensors & Bioelectronics, 2017, 91: 359–366

[49]

Li Q, Tang D, Lou F, . Simultaneous electrochemical multiplexed immunoassay of biomarkers based on multifunctionalized graphene nanotags. ChemElectroChem, 2014, 1(2): 441–447

[50]

Roberts A, Tripathi P P, Gandhi S. Graphene nanosheets as an electric mediator for ultrafast sensing of urokinase plasminogen activator receptor-A biomarker of cancer. Biosensors & Bioelectronics, 2019, 141: 111398

[51]

Tan Z, Cao L, Yang Y, . Amperometric immunoassay for the carcinoembryonic antigen by using a peroxidase mimic consisting of palladium nanospheres functionalized with glutathione-capped gold nanoparticles on graphene oxide. Microchimica Acta, 2019, 186(11): 693

[52]

Wu Y, Xue P, Kang Y, . Paper-based microfluidic electrochemical immunodevice integrated with nanobioprobes onto graphene film for ultrasensitive multiplexed detection of cancer biomarkers. Analytical Chemistry, 2013, 85(18): 8661–8668

[53]

Wu Y, Xue P, Kang Y, . Highly specific and ultrasensitive graphene-enhanced electrochemical detection of low-abundance tumor cells using silica nanoparticles coated with antibody-conjugated quantum dots. Analytical Chemistry, 2013, 85(6): 3166–3173

[54]

Yang K, Qi L, Gao Z, . A novel electrochemical immunosensor for prostate-specific antigen based on noncovalent nanocomposite of ferrocene monocarboxylic acid with graphene oxide. Analytical Letters, 2014, 47(13): 2266–2280

[55]

Qu F, Li T, Yang M. Colorimetric platform for visual detection of cancer biomarker based on intrinsic peroxidase activity of graphene oxide. Biosensors & Bioelectronics, 2011, 26(9): 3927–3931

[56]

Jonous Z A, Shayeh J S, Yazdian F, . An electrochemical biosensor for prostate cancer biomarker detection using graphene oxide–gold nanostructures. Engineering in Life Sciences, 2019, 19(3): 206–216

[57]

Alarfaj N A, El-Tohamy M F. A label-free electrochemical immunosensor based on gold nanoparticles and graphene oxide for the detection of tumor marker calcitonin. New Journal of Chemistry, 2017, 41(19): 11029–11035

[58]

Azimzadeh M, Rahaie M, Nasirizadeh N, . An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer. Biosensors & Bioelectronics, 2016, 77: 99–106

[59]

Park S, Singh A, Kim S, . Electroreduction-based electrochemical-enzymatic redox cycling for the detection of cancer antigen 15-3 using graphene oxide-modified indium-tin oxide electrodes. Analytical Chemistry, 2014, 86(3): 1560–1566

[60]

Pan L H, Kuo S H, Lin T Y, . An electrochemical biosensor to simultaneously detect VEGF and PSA for early prostate cancer diagnosis based on graphene oxide/ssDNA/PLLA nanoparticles. Biosensors & Bioelectronics, 2017, 89(Pt 1): 598–605

[61]

Pothipor C, Wiriyakun N, Putnin T, . Highly sensitive biosensors based on graphene–poly (3-aminobenzoic acid) modified electrodes and porous-hollowed-silver–gold nanoparticle labelling for prostate cancer detection. Sensors and Actuators B: Chemical, 2019, 296: 126657

[62]

Shekari Z, Zare H R, Falahati A. Electrochemical sandwich aptasensor for the carcinoembryonic antigen using graphene quantum dots, gold nanoparticles and nitrogen doped graphene modified electrode and exploiting the peroxidase-mimicking activity of a G-quadruplex DNAzyme. Microchimica Acta, 2019, 186(8): 530

[63]

Imran H, Manikandan P N, Prabhu D, . Ultra selective label free electrochemical detection of cancer prognostic p53-antibody at DNA functionalized graphene. Sensing and Bio-Sensing Research, 2019, 23: 100261

[64]

Jin B, Wang P, Mao H, . Multi-nanomaterial electrochemical biosensor based on label-free graphene for detecting cancer biomarkers. Biosensors & Bioelectronics, 2014, 55: 464–469

[65]

Kilic T, Erdem A, Erac Y, . Electrochemical detection of a cancer biomarker mir-21 in cell lysates using graphene modified sensors. Electroanalysis, 2015, 27(2): 317–326

[66]

Wang R, Xue C. A sensitive electrochemical immunosensor for alpha-fetoprotein based on covalently incorporating a bio-recognition element onto a graphene modified electrode via diazonium chemistry. Analytical Methods, 2013, 5(19): 5195–5200

[67]

Yang M, Javadi A, Li H, . Ultrasensitive immunosensor for the detection of cancer biomarker based on graphene sheet. Biosensors & Bioelectronics, 2010, 26(2): 560–565

[68]

Du D, Zou Z, Shin Y, . Sensitive immunosensor for cancer biomarker based on dual signal amplification strategy of graphene sheets and multienzyme functionalized carbon nanospheres. Analytical Chemistry, 2010, 82(7): 2989–2995

[69]

Lin C W, Wei K C, Liao S S, . A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis. Biosensors & Bioelectronics, 2015, 67: 431–437

[70]

Ali M A, Singh C, Srivastava S, . Graphene oxide-metal nanocomposites for cancer biomarker detection. RSC Advances, 2017, 7(57): 35982–35991

[71]

Pachauri N, Dave K, Dinda A, . Cubic CeO2 implanted reduced graphene oxide-based highly sensitive biosensor for non-invasive oral cancer biomarker detection. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2018, 6(19): 3000–3012

[72]

Salahandish R, Ghaffarinejad A, Omidinia E, . Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene. Biosensors & Bioelectronics, 2018, 120: 129–136

[73]

Xi J, Xie C, Zhang Y, . Pd nanoparticles decorated N-doped graphene quantum dots@N-doped carbon hollow nanospheres with high electrochemical sensing performance in cancer detection. ACS Applied Materials & Interfaces, 2016, 8(34): 22563–22573

[74]

Li H, He J, Li S, . Electrochemical immunosensor with N-doped graphene-modified electrode for label-free detection of the breast cancer biomarker CA 15-3. Biosensors & Bioelectronics, 2013, 43: 25–29

[75]

Yang L, Zhen S J, Li Y F, . Silver nanoparticles deposited on graphene oxide for ultrasensitive surface-enhanced Raman scattering immunoassay of cancer biomarker. Nanoscale, 2018, 10(25): 11942–11947

[76]

Singh V K, Kumar S, Pandey S K, . Fabrication of sensitive bioelectrode based on atomically thin CVD grown graphene for cancer biomarker detection. Biosensors & Bioelectronics, 2018, 105: 173–181

[77]

Miao L, Jiao L, Zhang J, . Amperometric sandwich immunoassay for the carcinoembryonic antigen using a glassy carbon electrode modified with iridium nanoparticles, polydopamine and reduced graphene oxide. Microchimica Acta, 2017, 184(1): 169–175

[78]

Barman S C, Hossain M F, Yoon H, . Trimetallic Pd@Au@Pt nanocomposites platform on −COOH terminated reduced graphene oxide for highly sensitive CEA and PSA biomarkers detection. Biosensors & Bioelectronics, 2018, 100: 16–22

[79]

Shahrokhian S, Salimian R. Ultrasensitive detection of cancer biomarkers using conducting polymer/electrochemically reduced graphene oxide-based biosensor: Application toward BRCA1 sensing. Sensors and Actuators B: Chemical, 2018, 266: 160–169

[80]

Yang M, Javadi A, Gong S. Sensitive electrochemical immunosensor for the detection of cancer biomarker using quantum dot functionalized graphene sheets as labels. Sensors and Actuators B: Chemical, 2011, 155(1): 357–360

[81]

Freitas M, Nouws H P A, Delerue-Matos C. Electrochemical sensing platforms for HER2-ECD breast cancer biomarker detection. Electroanalysis, 2019, 31(1): 121–128

[82]

Bai R G, Muthoosamy K, Shipton F N, . The biogenic synthesis of a reduced graphene oxide–silver (RGO–Ag) nanocomposite and its dual applications as an antibacterial agent and cancer biomarker sensor. RSC Advances, 2016, 6(43): 36576–36587

[83]

Assari P, Rafati A A, Feizollahi A, . An electrochemical immunosensor for the prostate specific antigen based on the use of reduced graphene oxide decorated with gold nanoparticles. Microchimica Acta, 2019, 186(7): 484

[84]

Shoja Y, Kermanpur A, Karimzadeh F. Diagnosis of EGFR exon21 L858R point mutation as lung cancer biomarker by electrochemical DNA biosensor based on reduced graphene oxide/functionalized ordered mesoporous carbon/Ni-oxytetracycline metallopolymer nanoparticles modified pencil graphite electrode. Biosensors & Bioelectronics, 2018, 113: 108–115

[85]

Ma H, Zhang X, Li X, . Electrochemical immunosensor for detecting typical bladder cancer biomarker based on reduced graphene oxide-tetraethylene pentamine and trimetallic AuPdPt nanoparticles. Talanta, 2015, 143: 77–82

[86]

Rauf S, Mishra G K, Azhar J, . Carboxylic group riched graphene oxide based disposable electrochemical immunosensor for cancer biomarker detection. Analytical Biochemistry, 2018, 545: 13–19

[87]

Shahzad F, Zaidi S A, Koo C M. Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection. Sensors and Actuators B: Chemical, 2017, 241: 716–724

[88]

Feng L, Wu L, Wang J, . Detection of a prognostic indicator in early-stage cancer using functionalized graphene-based peptide sensors. Advanced Materials, 2012, 24(1): 125–131

[89]

Kumar S, Sharma J G, Maji S, . Nanostructured zirconia decorated reduced graphene oxide based efficient biosensing platform for non-invasive oral cancer detection. Biosensors & Bioelectronics, 2016, 78: 497–504

[90]

Wang X, Wang C, Qu K, . Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes. Advanced Functional Materials, 2010, 20(22): 3967–3971

[91]

Zhang F R, Lu J Y, Yao Q F, . Matter, energy and information network of a graphene-peptide-based fluorescent sensing system for molecular logic computing, detection and imaging of cancer stem cell marker CD133 in cells and tumor tissues. The Analyst, 2019, 144(6): 1881–1891

[92]

Cui F, Ji J, Sun J, . A novel magnetic fluorescent biosensor based on graphene quantum dots for rapid, efficient, and sensitive separation and detection of circulating tumor cells. Analytical and Bioanalytical Chemistry, 2019, 411(5): 985–995

[93]

Cao Y, Dong H, Yang Z, . Aptamer-conjugated graphene quantum dots/porphyrin derivative theranostic agent for intracellular cancer-related microRNA detection and fluorescence-guided photothermal/photodynamic synergetic therapy. ACS Applied Materials & Interfaces, 2017, 9(1): 159–166

[94]

Song J, Wu S, Yang X, . A carboxylated graphene nanodisks/glucose oxidase nanotags and Mn:CdS/TiO2 matrix based dual signal amplification strategy for ultrasensitive photoelectrochemical detection of tumor markers. The Analyst, 2017, 142(24): 4647–4654

[95]

Hossain M B, Islam M M, Abdulrazak L F, . Graphene-coated optical fiber SPR biosensor for BRCA1 and BRCA2 breast cancer biomarker detection: a numerical design-based analysis. Photonic Sensors, 2020, 10(1): 67–79

[96]

Chiu N F, Lin T L, Kuo C T. Highly sensitive carboxyl-graphene oxide-based surface plasmon resonance immunosensor for the detection of lung cancer for cytokeratin 19 biomarker in human plasma. Sensors and Actuators B: Chemical, 2018, 265: 264–272

[97]

Al-Ogaidi I, Gou H, Aguilar Z P, . Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots. Chemical Communications, 2014, 50(11): 1344–1346

[98]

Pal M, Khan R. Graphene oxide layer decorated gold nanoparticles based immunosensor for the detection of prostate cancer risk factor. Analytical Biochemistry, 2017, 536: 51–58

[99]

Wang H, Chen H, Huang Z, . DNase I enzyme-aided fluorescence signal amplification based on graphene oxide–DNA aptamer interactions for colorectal cancer exosome detection. Talanta, 2018, 184: 219–226

[100]

Kim T H, Yoon H J, Fouladdel S, . Characterizing circulating tumor cells isolated from metastatic breast cancer patients using graphene oxide based microfluidic assay. Advanced Biosystems, 2019, 3(2): 1800278

[101]

Yang Z, Qin L, Yang D, . A graphene oxide fluorescent sensing platform for sensitive and specific detecting biomarker of radiation-resistant nasopharyngeal carcinoma. Bioorganic & Medicinal Chemistry Letters, 2019, 29(16): 2383–2386

[102]

Vilela P, El-Sagheer A, Millar T M, . Graphene oxide-upconversion nanoparticle based optical sensors for targeted detection of mRNA biomarkers present in Alzheimer’s disease and prostate cancer. ACS Sensors, 2017, 2(1): 52–56

[103]

Viraka Nellore B P, Kanchanapally R, Pramanik A, . Aptamer-conjugated graphene oxide membranes for highly efficient capture and accurate identification of multiple types of circulating tumor cells. Bioconjugate Chemistry, 2015, 26(2): 235–242

[104]

He L, Pagneux Q, Larroulet I, . Label-free femtomolar cancer biomarker detection in human serum using graphene-coated surface plasmon resonance chips. Biosensors & Bioelectronics, 2017, 89(Pt 1): 606–611

[105]

Tehrani Z, Burwell G, Azmi M A M, Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials, 2014, 1(2): 025004

[106]

Wang X, Wang C, Qu K, . Ultrasensitive and selective detection of a prognostic indicator in early stage cancer using graphene oxide and carbon nanotubes. Advanced Functional Materials, 2010, 20(22): 3967–3971

[107]

Sharker S M, Kang E B, Shin C I, . Near-infrared-active and pH-responsive fluorescent polymer-integrated hybrid graphene oxide nanoparticles for the detection and treatment of cancer. Journal of Applied Polymer Science, 2016, 133(32): 43791

[108]

Wang B, Song Y, Ge L, . Antibody-modified reduced graphene oxide film for circulating tumor cell detection in early-stage prostate cancer patients. RSC Advances, 2019, 9(17): 9379–9385

[109]

Cheng Y, Yuan R, Chai Y, . Highly sensitive luminol electrochemiluminescence immunosensor based on ZnO nanoparticles and glucose oxidase decorated graphene for cancer biomarker detection. Analytica Chimica Acta, 2012, 745: 137–142

[110]

Xu S, Liu Y, Wang T, . Positive potential operation of a cathodic electrogenerated chemiluminescence immunosensor based on luminol and graphene for cancer biomarker detection. Analytical Chemistry, 2011, 83(10): 3817–3823

[111]

Heidari R, Rashidiani J, Abkar M, . CdS nanocrystals/graphene oxide-AuNPs based electrochemiluminescence immunosensor in sensitive quantification of a cancer biomarker: p53. Biosensors & Bioelectronics, 2019, 126: 7–14

[112]

Liu F, Zhang Y, Ge S, . Magnetic graphene nanosheets based electrochemiluminescence immunoassay of cancer biomarker using CdTe quantum dots coated silica nanospheres as labels. Talanta, 2012, 99: 512–519

[113]

Rashidiani J, Kamali M, Sedighian H, . Ultrahigh sensitive enhanced-electrochemiluminescence detection of cancer biomarkers using silica NPs/graphene oxide: A comparative study. Biosensors & Bioelectronics, 2018, 102: 226–233

[114]

Cui M, Yu R, Wang X, . Novel graphene/Au-CdS:Eu composite-based electrochemiluminescence immunosensor for cancer biomarker detection by coupling resonance energy transfer and enzyme catalytic reaction. Journal of Electroanalytical Chemistry, 2016, 781: 410–417

[115]

He Q, Wu S, Yin Z, . Graphene-based electronic sensors. Chemical Science, 2012, 3(6): 1764–1772

[116]

Hao Z, Pan Y, Shao W, . Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva. Biosensors & Bioelectronics, 2019, 134: 16–23

[117]

Myung S, Solanki A, Kim C, . Graphene-encapsulated nanoparticle-based biosensor for the selective detection of cancer biomarkers. Advanced Materials, 2011, 23(19): 2221–2225

[118]

Rajesh, Gao Z, Vishnubhotla R, . Genetically engineered antibody functionalized platinum nanoparticles modified CVD-graphene nanohybrid transistor for the detection of breast cancer biomarker, HER3. Advanced Materials Interfaces, 2016, 3(17): 1600124

[119]

Zhou L, Wang K, Sun H, . Novel graphene biosensor based on the functionalization of multifunctional nano-bovine serum albumin for the highly sensitive detection of cancer biomarkers. Nano-Micro Letters, 2019, 11(1): 20

[120]

Hao Z, Pan Y, Huang C, . Sensitive detection of lung cancer biomarkers using an aptameric graphene-based nanosensor with enhanced stability. Biomedical Microdevices, 2019, 21(3): 65

[121]

Mansouri Majd S, Salimi A. Ultrasensitive flexible FET-type aptasensor for CA 125 cancer marker detection based on carboxylated multiwalled carbon nanotubes immobilized onto reduced graphene oxide film. Analytica Chimica Acta, 2018, 1000: 273–282

[122]

Nag S, Duarte L, Bertrand E, . Ultrasensitive QRS made by supramolecular assembly of functionalized cyclodextrins and graphene for the detection of lung cancer VOC biomarkers. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2014, 2(38): 6571–6579

[123]

Koncki R. Recent developments in potentiometric biosensors for biomedical analysis. Analytica Chimica Acta, 2007, 599(1): 7–15

[124]

Hong Z, Chen G, Yu S, . A potentiometric aptasensor for carcinoembryonic antigen (CEA) on graphene oxide nanosheets using catalytic recycling of DNase I with signal amplification. Analytical Methods, 2018, 10(45): 5364–5371

[125]

Li F, Hu S, Zhang R, . Porous graphene oxide enhanced aptamer specific circulating-tumor-cell sensing interface on light addressable potentiometric sensor: clinical application and simulation. ACS Applied Materials & Interfaces, 2019, 11(9): 8704–8709

[126]

Truta L A, Ferreira N S, Sales M G F. Graphene-based biomimetic materials targeting urine metabolite as potential cancer biomarker: application over different conductive materials for potentiometric transduction. Electrochimica Acta, 2014, 150: 99–107

[127]

Sur U K. Surface-enhanced Raman spectroscopy. Resonance, 2010, 15(2): 154–164

[128]

Kumar S, Kumar S, Srivastava S, . Reduced graphene oxide modified smart conducting paper for cancer biosensor. Biosensors & Bioelectronics, 2015, 73: 114–122

[129]

Papi M, Palmieri V, Digiacomo L, . Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection. Nanoscale, 2019, 11(32): 15339–15346

[130]

Zhang X F, Zhang Z W, He Y L, . Sniffing lung cancer related biomarkers using an oxidized graphene SAW sensor. Frontiers of Physics, 2016, 11(2): 116801

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