Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

Abstract

Hollow mesoporous silica nanoparticles (HMSNs) have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties, large specific surface area and facile functionalization, especially made into intelligent drug delivery systems (DDSs) for cancer therapy. HMSNs are employed to transport traditional anti-tumor drugs, which can solve the problems of drugs with instability, poor solubility and lack of recognition, etc., while significantly improving the anti-tumor effect. And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment. Actually, HMSNs-based DDSs have developed relatively mature in recent years. This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS, as well as its degradation, different stimuli-responses, targets and combination therapy. These versatile intelligent nanoparticles show great potential in clinical aspects.

Keywords

hollow mesoporous silica nanoparticles / intelligent drug delivery system / stimuli response / targeting drug delivery / combination therapy

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Acknowledgement

This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 51773162 and 21204071).

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2020 Higher Education Press