Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering

Abstract

A novel composite scaffold based on chitosan-collagen/organomontmo-rillonite (CS-COL/OMMT) was prepared to improve swelling ratio, biodegradation ratio, biomineralization and mechanical properties for use in tissue engineering applications. In order to expend the basal spacing, montmorillonite (MMT) was modified with sodium dodecyl sulfate (SDS) and was characterized by XRD, TGA and FTIR. The results indicated that the anionic surfactants entered into interlayer of MMT and the basal spacing of MMT was expanded to 3.85 nm. The prepared composite scaffolds were characterized by FTIR, XRD and SEM. The swelling ratio, biodegradation ratio and mechanical properties of composite scaffolds were also studied. The results demonstrated that the scaffold decreased swelling ratio, degradation ratio and improved mechanical and biomineralization properties because of OMMT.

Keywords

chitosan (CS) / collagen (COL) / montmorillonite (MMT) / sodium dodecyl sulfate (SDS)

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Acknowledgements

The authors acknowledge the financial support of the International Science Cooperation Program of Hainan (Grant Nos. KJHZ2014-19 and KJHZ2015-02). This work was also financially supported by the National Natural Science Foundation of China (NSFC, Grant Nos. 51162006, 51362009 and 51361009) and the Key Science & Technology Project (ZDXM2015118).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg