Synthesis and thermal stability of selenium-doped hydroxyapatite with different substitutions

Abstract

Selenium (Se) plays a specific role in human health, especially for its anti-tumor effect. Incorporation of selenium into biocompatible hydroxyapatite (HAP) may endow the materials with novel characteristics. In the current work, a series of selenium-doped hydroxyapatite (Se-HAP) nanoparticles with different Se/P ratios were synthesized by a modified chemical precipitation. It was revealed that the powders with/without heat-treatment were nano-sized needle-like HAP while the heat-treated samples have high crystallinity. The addition of selenium decreases the crystallinity of the synthesized apatite, and also takes a negative effect on the thermal stability of the as-prepared powders. The Se-HAP nanoparticles with Se/P molar ratio not more than 5% sintered at 900°C can achieve good crystallinity and thermal stability.

Keywords

selenium / hydroxyapatite / thermal stability / crystallinity

References

[1] Zakaria S M, Sharif Zein S H, Othman M R, . Nanophase hydroxyapatite as a biomaterial in advanced hard tissue engineering: a review. Tissue Engineering Part B: Reviews, 2013, 19(5): 431–441

[2] Koutsopoulos S. Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods. Journal of Biomedical Materials Research, 2002, 62(4): 600–612

[3] Ong J L, Chan D C N. Hydroxyapatite and their use as coatings in dental implants: a review. Critical Reviews in Biomedical Engineering, 2000, 28(5−6): 667–707

[4] Paluszkiewicz C, Slosarczyk A, Pijocha D, . Synthesis, structural properties and thermal stability of Mn-doped hydroxyapatite. Journal of Molecular Structure, 2010, 976(1−3): 301–309

[5] Featherstone J D B. Prevention and reversal of dental caries: role of low level fluoride. Community Dentistry and Oral Epidemiology, 1999, 27(1): 31–40

[6] Ren F, Leng Y, Xin R, . Synthesis, characterization and ab initio simulation of magnesium-substituted hydroxyapatite. Acta Biomaterialia, 2010, 6(7): 2787–2796

[7] Qiu Z Y, Li G, Zhang Y Q, . Fine structure analysis and sintering properties of Si-doped hydroxyapatite. Biomedical Materials, 2012, 7(4): 045009

[8] Batra U, Kapoor S, Sharma S. Influence of magnesium ion substitution on structural and thermal behavior of nanodimensional hydroxyapatite. Journal of Materials Engineering and Performance, 2013, 22(6): 1798–1806

[9] Letavayová L, Vlcková V, Brozmanová J. Selenium: from cancer prevention to DNA damage. Toxicology, 2006, 227(1−2): 1–14

[10] Xiong G. Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. International Orthopaedics, 2001, 25(3): 147–150

[11] Montero M, Diaz-Curiel M, Dapia S, . Kalsis, a food supplement, decreases the ovariectomy-induced osteopenia in rats. Bone, 2009, 44: S437–S438

[12] Wang Y, Ma J, Zhou L, . Dual functional selenium-substituted hydroxyapatite. Interface Focus, 2012, 2(3): 378–386

[13] Aina V, Bergandi L, Lusvardi G, . Sr-containing hydroxyapatite: morphologies of HA crystals and bioactivity on osteoblast cells. Materials Science and Engineering C, 2013, 33(3): 1132–1142

[14] Lafon J P, Champion E, Bernache-Assollant D. Processing of AB-type carbonated hydroxyapatite Ca_10−x(PO₄)_6−x(CO₃)_x(OH)_2−x−2y(CO₃)_y ceramics with controlled composition. Journal of the European Ceramic Society, 2008, 28(1): 139–147

[15] Zhang H Q, Zhang M. Characterization and thermal behavior of calcium deficient hydroxyapatite whiskers with various Ca/P ratios. Materials Chemistry and Physics, 2011, 126(3): 642–648

Rights & permissions

Higher Education Press and Springer-Verlag Berlin Heidelberg