Synthesis and thermal stability of selenium-doped hydroxyapatite with different substitutions

Abstract

Selenium (Se) plays a specific role in human health, especially for its anti-tumor effect. Incorporation of selenium into biocompatible hydroxyapatite (HAP) may endow the materials with novel characteristics. In the current work, a series of selenium-doped hydroxyapatite (Se-HAP) nanoparticles with different Se/P ratios were synthesized by a modified chemical precipitation. It was revealed that the powders with/without heat-treatment were nano-sized needle-like HAP while the heat-treated samples have high crystallinity. The addition of selenium decreases the crystallinity of the synthesized apatite, and also takes a negative effect on the thermal stability of the as-prepared powders. The Se-HAP nanoparticles with Se/P molar ratio not more than 5% sintered at 900°C can achieve good crystallinity and thermal stability.

Keywords

selenium / hydroxyapatite / thermal stability / crystallinity

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Acknowledgements

This work was supported by the National Basic Research Program of China (Grant No. 2012CB933601) and the National Natural Science Foundation of China (Grant Nos. 51202075, 81071263 and 81461148032).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg