Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Abstract

To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing--dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

Keywords

chitosan fiber / surface N-succinylation / liquor absorptivity / part-dissolvability / wound dressing

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81271727 and 31300786), the International Science Technology Cooperation Program of China (Grant No. 2012DFB50140), Ph.D. Programs Foundation of Ministry of Education of China (Grant No. 20120132110012), the National Science Foundation for Post-doctor (Grant No. 2013M541961), and Applied Basic Research Plan of Qingdao (Grant No. 14-2-4-98-jch).

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81271727 and 31300786), the International Science Technology Cooperation Program of China (Grant No. 2012DFB50140), Ph.D. Programs Foundation of Ministry of Education of China (Grant No. 20120132110012), the National Science Foundation for Post-doctor (Grant No. 2013M541961), and Applied Basic Research Plan of Qingdao (Grant No. 14-2-4-98-jch).

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg