Magnesium based degradable biomaterials: A review

Abstract

Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg--Ca, Mg--Sr, Mg--Zn and Mg--REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.

Keywords

magnesium alloy / degradable biomaterial / coating / degradation / corrosion

References

[1] Witte F, Kaese V, Haferkamp H, . In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials, 2005, 26(17): 3557–3563

[2] Witte F, Fischer J, Nellesen J, . In vitro and in vivo corrosion measurements of magnesium alloys. Biomaterials, 2006, 27(7): 1013–1018

[3] Li Z, Gu X, Lou S, . The development of binary Mg–Ca alloys for use as biodegradable materials within bone. Biomaterials, 2008, 29(10): 1329–1344

[4] Erbel R, Di Mario C, Bartunek J, . Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial. Lancet, 2007, 369(9576): 1869–1875

[5] Haude M, Erbel R, Erne P, . Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial. Lancet, 2013, 381(9869): 836–844

[6] Gruhl S, Witte F, Vogt J, . Determination of concentration gradients in bone tissue generated by a biologically degradable magnesium implant. Journal of Analytical Atomic Spectrometry, 2009, 24(2): 181–188

[7] Krause A, Höh N, Bormann D, . Degradation behaviour and mechanical properties of magnesium implants in rabbit tibiae. Journal of Materials Science, 2010, 45(3): 624–632

[8] Bowman B A, Russell R M. Present Knowledge in Nutrition. 9th ed. Washington DC: International Life Science Institute Press, 2006

[9] Staiger M P, Pietak A M, Huadmai J, . Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials, 2006, 27(9): 1728–1734

[10] Zheng Y F, Gu X N, Witte F. Biodegradable metals. Materials Science and Engineering R: Reports, 2014, 77: 1–34

[11] Saw B A. Corrosion resistance of magnesium alloy. In: Cramer D S, Covino B S, eds. ASM Handbook Volume 13A: Corrosion Fundamentals, Testing and Protection. UK: ASM International, 2003

[12] Erdmann N, Angrisani N, Reifenrath J, . Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits. Acta Biomaterialia, 2011, 7(3): 1421–1428

[13] Gu X N, Xie X H, Li N, . In vitro and in vivo studies on an Mg–Sr binary alloy system developed as a new kind of biodegradable metal. Acta Biomaterialia, 2012, 8(6): 2360–2374

[14] Tan L, Wang Q, Lin X, . Loss of mechanical properties in vivo and bone–implant interface strength of AZ31B magnesium alloy screws with Si-containing coating. Acta Biomaterialia, 2014, 10(5): 2333–2340

[15] Fischer J, Prosenc M H, Wolff M, . Interference of magnesium corrosion with tetrazolium-based cytotoxicity assays. Acta Biomaterialia, 2010, 6(5): 1813–1823

[16] Lorenz C, Brunner J G, Kollmannsberger P, . Effect of surface pre-treatments on biocompatibility of magnesium. Acta Biomaterialia, 2009, 5(7): 2783–2789

[17] Song G. Control of biodegradation of biocompatable magnesium alloys. Corrosion Science, 2007, 49(4): 1696–1701

[18] Sun H, Li C, Xie Y, . Microstructures and mechanical properties of pure magnesium bars by high ratio extrusion and its subsequent annealing treatment. Transactions of Nonferrous Metals Society of China, 2012, 22(Supplement 2): s445–s449

[19] Yamagishi H, Fukuhara M, Chiba A. Determination of the cyclic-tension fatigue of extruded pure magnesium using multiple ultrasonic waves. Materials Transactions, 2010, 51(7): 1255–1263

[20] Witte F, Hort N, Vogt C, . Degradable biomaterials based on magnesium corrosion. Current Opinion in Solid State and Materials Science, 2008, 12(5–6): 63–72

[21] Atrens A, Liu M, Zainal Abidin N I. Corrosion mechanism applicable to biodegradable magnesium implants. Materials Science and Engineering B, 2011, 176(20): 1609–1636

[22] Gu X, Zheng Y, Cheng Y, . In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials, 2009, 30(4): 484–498

[23] Bornapour M, Muja N, Shum-Tim D, . Biocompatibility and biodegradability of Mg–Sr alloys: The formation of Sr-substituted hydroxyapatite. Acta Biomaterialia, 2013, 9(2): 5319–5330

[24] Chang T C, Wang J Y, Chu C L, . Mechanical properties and microstructures of various Mg–Li alloys. Materials Letters, 2006, 60(27): 3272–3276

[25] Song G, Atrens A. Corrosion mechanisms of magnesium alloys. Advanced Engineering Materials, 1999, 1(1): 11–33

[26] Zeng R, Zhang J, Huang W, . Review of studies on corrosion of magnesium alloys. Transactions of Nonferrous Metals Society of China, 2006, 16(Supplement 2): s763–s771

[27] Zeng R, Dietzel W, Witte F, . Progress and challenge for magnesium alloys as biomaterials. Advanced Engineering Materials, 2008, 10(8): B3–B14

[28] Zeng R C, Sun L, Zheng Y F, . Corrosion and characterization of dual phase Mg–Li–Ca alloy in Hank’s solution: The influence of microstructural features. Corrosion Science, 2014, 79: 69–82

[29] Seiler H G, Sigel H, Sigel A. Handbook of Toxicity of Inorganic Compounds. New York: Marcel Dekker Inc., 1988

[30] Sigel H. Metal Ions in Biological System. New York: Marcel Dekker Inc., 1986

[31] Nakamura Y, Tsumura Y, Tonogai Y, . Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. Fundamental and Applied Toxicology, 1997, 37(2): 106–116

[32] Wan Y, Xiong G, Luo H, . Preparation and characterization of a new biomedical magnesium–calcium alloy. Materials & Design, 2008, 29(10): 2034–2037

[33] Liu C L, Wang Y J, Zeng R C, . In vitro corrosion degradation behaviour of Mg–Ca alloy in the presence of albumin. Corrosion Science, 2010, 52(10): 3341–3347

[34] Drynda A, Hassel T, Hoehn R, . Development and biocompatibility of a novel corrodible fluoride-coated magnesium–calcium alloy with improved degradation kinetics and adequate mechanical properties for cardiovascular applications. Journal of Biomedical Materials Research Part A, 2010, 93A: 763–775

[35] Jeong Y S, Kim W J. Enhancement of mechanical properties and corrosion resistance of Mg–Ca alloys through microstructural refinement by indirect extrusion. Corrosion Science, 2014, 82: 392–403

[36] Han H-S, Yin M H, Seok H-K, . The modification of microstructure to improve the biodegradation and mechanical properties of a biodegradable Mg alloy. Journal of the Mechanical Behavior of Biomedical Materials, 2013, 20: 54–60

[37] Guo Y B, Salahshoor M. Process mechanics and surface integrity by high-speed dry milling of biodegradable magnesium–calcium implant alloys. CIRP Annals - Manufacturing Technology, 2010, 59(1): 151–154

[38] Salahshoor M, Guo Y B. Cutting mechanics in high speed dry machining of biomedical magnesium–calcium alloy using internal state variable plasticity model. International Journal of Machine Tools & Manufacture, 2011, 51(7–8): 579–590

[39] Sealy M P, Guo Y B. Surface integrity and process mechanics of laser shock peening of novel biodegradable magnesium–calcium (Mg–Ca) alloy. Journal of the Mechanical Behavior of Biomedical Materials, 2010, 3(7): 488–496

[40] Salahshoor M, Guo Y. Biodegradable orthopedic magnesium–calcium (MgCa) alloys, processing, and corrosion performance. Materials, 2012, 5(12): 135–155

[41] Marie P J. Strontium ranelate: A physiological approach for optimizing bone formation and resorption. Bone, 2006, 38(2): 10–14

[42] Dahl S G, Allain P, Marie P J, . Incorporation and distribution of strontium in bone. Bone, 2001, 28(4): 446–453

[43] Zhang W, Shen Y, Pan H, . Effects of strontium in modified biomaterials. Acta Biomaterialia, 2011, 7(2): 800–808

[44] Pors Nielsen S. The biological role of strontium. Bone, 2004, 35(3): 583–588

[45] Brar H S, Wong J, Manuel M V. Investigation of the mechanical and degradation properties of Mg–Sr and Mg–Zn–Sr alloys for use as potential biodegradable implant materials. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 7: 87–95

[46] Avedesian M M, Baker H. ASM Specialty Handbook – Magnesium and Magnesium Alloys. Ohio: ASM International, 1999

[47] Zhang S, Zhang X, Zhao C, . Research on an Mg–Zn alloy as a degradable biomaterial. Acta Biomaterialia, 2010, 6(2): 626–640

[48] Hofstetter J, Becker M, Martinelli E, . High-strength low-alloy (HSLA) Mg–Zn–Ca alloys with excellent biodegradation performance. JOM, 2014, 66(4): 566–572

[49] Gao J H, Guan S K, Ren Z W, . Homogeneous corrosion of high pressure torsion treated Mg–Zn–Ca alloy in simulated body fluid. Materials Letters, 2011, 65(4): 691–693

[50] Zhang B, Hou Y, Wang X, . Mechanical properties, degradation performance and cytotoxicity of Mg–Zn–Ca biomedical alloys with different compositions. Materials Science and Engineering C, 2011, 31(8): 1667–1673

[51] Sun Y, Zhang B, Wang Y, . Preparation and characterization of a new biomedical Mg–Zn–Ca alloy. Materials & Design, 2012, 34: 58–64

[52] Yin P, Li N, Lei T, . Effects of Ca on microstructure, mechanical and corrosion properties and biocompatibility of Mg–Zn–Ca alloys. Journal of Materials Science: Materials in Medicine, 2013, 24(6): 1365–1373

[53] Cipriano A, Zhao T, Johnson I, . In vitro degradation of four magnesium–zinc–strontium alloys and their cytocompatibility with human embryonic stem cells. Journal of Materials Science: Materials in Medicine, 2013, 24(4): 989–1003

[54] Guan R, Cipriano A F, Zhao Z y, . Development and evaluation of a magnesium–zinc–strontium alloy for biomedical applications — Alloy processing, microstructure, mechanical properties, and biodegradation. Materials Science and Engineering C, 2013, 33(7): 3661–3669

[55] Hänzi A C, Sologubenko A S, Uggowitzer P J. Design strategy for new biodegradable Mg–Y–Zn alloys for medical applications. International Journal of Materials Research, 2009, 100(8): 1127–1136

[56] Wu Q, Zhu S, Wang L, . The microstructure and properties of cyclic extrusion compression treated Mg–Zn–Y–Nd alloy for vascular stent application. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 8: 1–7

[57] Zhang E, He W, Du H, . Microstructure, mechanical properties and corrosion properties of Mg–Zn–Y alloys with low Zn content. Materials Science and Engineering A, 2008, 488(1–2): 102–111

[58] Hänzi A C, Gerber I, Schinhammer M, . On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg–Y–Zn alloys. Acta Biomaterialia, 2010, 6(5): 1824–1833

[59] Willbold E, Kalla K, Bartsch I, . Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal. Acta Biomaterialia, 2013, 9(10): 8509–8517

[60] Xu L, Zhang E, Yang K. Phosphating treatment and corrosion properties of Mg–Mn–Zn alloy for biomedical application. Journal of Materials Science: Materials in Medicine, 2009, 20(4): 859–867

[61] Xu L P, Yu G N, Zhang E, . In vivo corrosion behavior of Mg–Mn–Zn alloy for bone implant application. Journal of Biomedical Materials Research Part A, 2007, 83A(3): 703–711

[62] Zhang E, Yin D, Xu L, . Microstructure, mechanical and corrosion properties and biocompatibility of Mg–Zn–Mn alloys for biomedical application. Materials Science and Engineering C, 2009, 29(3): 987–993

[63] Zhang E, Yang L. Microstructure, mechanical properties and bio-corrosion properties of Mg–Zn–Mn–Ca alloy for biomedical application. Materials Science and Engineering A, 2008, 497(1–2): 111–118

[64] Bae D H, Kim S H, Kim D H, . Deformation behavior of Mg–Zn–Y alloys reinforced by icosahedral quasicrystalline particles. Acta Materialia, 2002, 50(9): 2343–2356

[65] Pierce F S, Poon S J, Guo Q. Electron localization in metallic quasicrystals. Science, 1993, 261(5122): 737–739

[66] Lee J Y, Kim D H, Lim H K, . Effects of Zn/Y ratio on microstructure and mechanical properties of Mg–Zn–Y alloys. Materials Letters, 2005, 59(29–30): 3801–3805

[67] Rosalbino F, De Negri S, Saccone A, . Bio-corrosion characterization of Mg–Zn–X (X= Ca, Mn, Si) alloys for biomedical applications. Journal of Materials Science: Materials in Medicine, 2010, 21(4): 1091–1098

[68] Zhang E, Xu L, Yu G, . In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation. Journal of Biomedical Materials Research Part A, 2009, 90A(3): 882–893

[69] Feyerabend F, Fischer J, Holtz J, . Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines. Acta Biomaterialia, 2010, 6(5): 1834–1842

[70] Birbilis N, Easton M A, Sudholz A D, . On the corrosion of binary magnesium–rare earth alloys. Corrosion Science, 2009, 51(3): 683–689

[71] Friedrich H E, Mordike B L. Magnesium Technology – Metallurgy, Design Date, Applications. New York: Springer Berlin Heidelberg, 2005

[72] Zhang X, Yuan G, Niu J, . Microstructure, mechanical properties, biocorrosion behavior, and cytotoxicity of as-extruded Mg–Nd–Zn–Zr alloy with different extrusion ratios. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 9: 153–162

[73] Zhang X, Yuan G, Mao L, . Effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of an Mg–Nd–Zn–Zr alloy. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 7: 77–86

[74] Zhang X, Yuan G, Mao L, . Biocorrosion properties of as-extruded Mg–Nd–Zn–Zr alloy compared with commercial AZ31 and WE43 alloys. Materials Letters, 2012, 66(1): 209–211

[75] Zhang X, Yuan G, Wang Z. Mechanical properties and biocorrosion resistance of Mg–Nd–Zn–Zr alloy improved by cyclic extrusion and compression. Materials Letters, 2012, 74: 128–131

[76] Chang J W, Fu P H, Guo X W, . The effects of heat treatment and zirconium on the corrosion behaviour of Mg–3Nd–0.2Zn–0.4Zr (wt.%) alloy. Corrosion Science, 2007, 49(6): 2612–2627

[77] Peng Q, Huang Y, Zhou L, . Preparation and properties of high purity Mg–Y biomaterials. Biomaterials, 2010, 31(3): 398–403

[78] Hort N, Huang Y, Fechner D, . Magnesium alloys as implant materials – Principles of property design for Mg–RE alloys. Acta Biomaterialia, 2010, 6(5): 1714–1725

[79] Yang L, Hort N, Laipple D, . Element distribution in the corrosion layer and cytotoxicity of alloy Mg–10Dy during in vitro biodegradation. Acta Biomaterialia, 2013, 9(10): 8475–8487

[80] Yang L, Huang Y, Feyerabend F, . Microstructure, mechanical and corrosion properties of Mg–Dy–Gd–Zr alloys for medical applications. Acta Biomaterialia, 2013, 9(10): 8499–8508

[81] Yang L, Huang Y, Feyerabend F, . Influence of ageing treatment on microstructure, mechanical and bio-corrosion properties of Mg–Dy alloys. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 13: 36–44

[82] Yang L, Huang Y, Peng Q, . Mechanical and corrosion properties of binary Mg–Dy alloys for medical applications. Materials Science and Engineering B, 2011, 176(20): 1827–1834

[83] Brar H S, Berglund I S, Allen J B, . The role of surface oxidation on the degradation behavior of biodegradable Mg–RE (Gd, Y, Sc) alloys for resorbable implants. Materials Science and Engineering C, 2014, 40: 407–417

[84] Liu M, Schmutz P, Uggowitzer P J, . The influence of yttrium (Y) on the corrosion of Mg–Y binary alloys. Corrosion Science, 2010, 52(11): 3687–3701

[85] Zhang X, Zhang K, Deng X, . Corrosion behavior of Mg–Y alloy in NaCl aqueous solution. Progress in Natural Science: Materials International, 2012, 22(2): 169–174

[86] Datta M K, Chou D T, Hong D, . Structure and thermal stability of biodegradable Mg–Zn–Ca based amorphous alloys synthesized by mechanical alloying. Materials Science and Engineering B, 2011, 176(20): 1637–1643

[87] Gu X N, Zheng Y F, Zhong S P, . Corrosion of, and cellular responses to Mg–Zn–Ca bulk metallic glasses. Biomaterials, 2010, 31(6): 1093–1103

[88] Ma E, Xu J. Biodegradable alloys: The glass window of opportunities. Nature Materials, 2009, 8(11): 855–857

[89] Wessels V, Le Mené G, Fischerauer S F, . In vivo performance and structural relaxation of biodegradable bone implants made from Mg–Zn–Ca bulk metallic glasses. Advanced Engineering Materials, 2012, 14(6): B357–B364

[90] Zberg B, Uggowitzer P J, Loffler J F. MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. Nature Materials, 2009, 8(11): 887–891

[91] Zhao Y Y, Zhao X. Structural relaxation and its influence on the elastic properties and notch toughness of Mg–Zn–Ca bulk metallic glass. Journal of Alloys and Compounds, 2012, 515: 154–160

[92] Zberg B, Arata E R, Uggowitzer P J, . Tensile properties of glassy MgZnCa wires and reliability analysis using Weibull statistics. Acta Materialia, 2009, 57(11): 3223–3231

[93] Zarandi F, Yue S. Magnesium sheet, challenges and opportunities. In: Czerwinski F, ed. Magnesium Alloys – Design, Processing and Properties. InTech, 2011

[94] Kang F, Liu J Q, Wang J T, . Equal channel angular pressing of a Mg–3Al–1Zn alloy with back pressure. Advanced Engineering Materials, 2010, 12(8): 730–734

[95] Gu X N, Li N, Zheng Y F, . In vitro study on equal channel angular pressing AZ31 magnesium alloy with and without back pressure. Materials Science and Engineering B, 2011, 176(20): 1802–1806

[96] Wang H, Estrin Y, Zúberová Z. Bio-corrosion of a magnesium alloy with different processing histories. Materials Letters, 2008, 62(16): 2476–2479

[97] Wang H, Estrin Y, Fu H, . The effect of pre-processing and grain structure on the bio-corrosion and fatigue resistance of magnesium alloy AZ31. Advanced Engineering Materials, 2007, 9(11): 967–972

[98] Alvarez-Lopez M, Pereda M D, del Valle J A, . Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids. Acta Biomaterialia, 2010, 6(5): 1763–1771

[99] Hornberger H, Virtanen S, Boccaccini A R. Biomedical coatings on magnesium alloys – A review. Acta Biomaterialia, 2012, 8(7): 2442–2455

[100] Shadanbaz S, Dias G J. Calcium phosphate coatings on magnesium alloys for biomedical applications: A review. Acta Biomaterialia, 2012, 8(1): 20–30

[101] Surmenev R A, Surmeneva M A, Ivanova A A. Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis — A review. Acta Biomaterialia, 2014, 10(2): 557–579

[102] Zhang Y, Zhang G, Wei M. Controlling the biodegradation rate of magnesium using biomimetic apatite coating. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2009, 89B(2): 408–414

[103] Yang J X, Cui F Z, Yin Q S, . Characterization and degradation study of calcium phosphate coating on magnesium alloy bone implant in vitro. IEEE Transactions on Plasma Sciences, 2009, 37(7): 1161–1168

[104] Gray-Munro J E, Strong M. The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31. Journal of Biomedical Materials Research Part A, 2009, 90A(2): 339–350

[105] Zeng R, Sun X, Song Y, . Influence of solution temperature on corrosion resistance of Zn–Ca phosphate conversion coating on biomedical Mg–Li–Ca alloys. Transactions of Nonferrous Metals Society of China, 2013, 23(11): 3293–3299

[106] Wang Q, Tan L, Xu W, . Dynamic behaviors of a Ca–P coated AZ31B magnesium alloy during in vitro and in vivo degradations. Materials Science and Engineering B, 2011, 176(20): 1718–1726

[107] Chen X B, Birbilis N, Abbott T B. A simple route towards a hydroxyapatite–Mg(OH)₂ conversion coating for magnesium. Corrosion Science, 2011, 53(6): 2263–2268

[108] Zhang C-Y, Zeng R-C, Liu C-L, . Comparison of calcium phosphate coatings on Mg–Al and Mg–Ca alloys and their corrosion behavior in Hank’s solution. Surface and Coatings Technology, 2010, 204(21–22): 3636–3640

[109] Zhang C y, Zeng R, Chen R, . Preparation of calcium phosphate coatings on Mg–1.0Ca alloy. Transactions of Nonferrous Metals Society of China, 2010, 20(Supplement 2): s655–s659

[110] Song Y W, Shan D Y, Han E H. Electrodeposition of hydroxyapatite coating on AZ91D magnesium alloy for biomaterial application. Materials Letters, 2008, 62(17–18): 3276–3279

[111] Kannan M B, Orr L. In vitro mechanical integrity of hydroxyapatite coated magnesium alloy. Biomedical Materials, 2011, 6(4): 045003

[112] Song Y, Zhang S, Li J, . Electrodeposition of Ca–P coatings on biodegradable Mg alloy: In vitro biomineralization behavior. Acta Biomaterialia, 2010, 6(5): 1736–1742

[113] Wang H X, Guan S K, Wang X, . In vitro degradation and mechanical integrity of Mg–Zn–Ca alloy coated with Ca-deficient hydroxyapatite by the pulse electrodeposition process. Acta Biomaterialia, 2010, 6(5): 1743–1748

[114] Wang H, Guan S, Wang Y, . In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg–Zn–Ca alloy for bone implant application. Colloids and Surfaces B: Biointerfaces, 2011, 88(1): 254–259

[115] Yao Z, Li L, Jiang Z. Adjustment of the ratio of Ca/P in the ceramic coating on Mg alloy by plasma electrolytic oxidation. Applied Surface Science, 2009, 255(13–14): 6724–6728

[116] Srinivasan P B, Liang J, Blawert C, . Characterization of calcium containing plasma electrolytic oxidation coatings on AM50 magnesium alloy. Applied Surface Science, 2010, 256(12): 4017–4022

[117] Li J N, Cao P, Zhang X N, . In vitro degradation and cell attachment of a PLGA coated biodegradable Mg–6Zn based alloy. Journal of Materials Science, 2010, 45(22): 6038–6045

[118] Gu X N, Zheng Y F, Lan Q X, . Surface modification of an Mg–1Ca alloy to slow down its biocorrosion by chitosan. Biomedical Materials, 2009, 4(4): 044109

[119] Xu L, Yamamoto A. Characteristics and cytocompatibility of biodegradable polymer film on magnesium by spin coating. Colloids and Surfaces B: Biointerfaces, 2012, 93: 67–74

[120] Xu L, Yamamoto A. In vitro degradation of biodegradable polymer-coated magnesium under cell culture condition. Applied Surface Science, 2012, 258(17): 6353–6358

[121] Wong H M, Yeung K W K, Lam K O, . A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials, 2010, 31(8): 2084–2096

[122] Windhagen H, Radtke K, Weizbauer A, . Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study. Biomedical Engineering Online, 2013, 12(1): 62 (10 pages)

Acknowledgements

This work was supported by the National Basic Research Program of China (973 Program) (Grant Nos. 2012CB619102 and 2012CB619100), Specialized Research Fund for the Doctoral Program of Higher Education under Grant No. 20121102120037, the National Natural Science Foundation of China (Grant No. 31370959), Fok Ying Tong Education Foundation (Grant No. 141039), and Beijing Natural Science Foundation (Grant No. 7142094). Xuenan would like to thank Dr. Fuzhai Cui at Tsinghua University for the kindly invitation of this review.

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