Tumor-suppressor effects of chemical functional groups in an in vitro co-culture system

Abstract

Liver normal cells and cancer cells co-cultured on surfaces modified by different chemical functional groups, including mercapto (--SH), hydroxyl (--OH) and methyl (--CH₃) groups. The results showed that different cells exhibited changes in response to different surfaces. Normal cells on --SH surface exhibited the smallest contact area with mostly rounded morphology, which led to the death of cancer cells, while cancer cells could not grow on --CH₃ groups, which also died. In the co-culture system, the --CH₃ group exhibited its unique effect that could trigger the death of cancer cells and had no effects on normal cells. Our findings provide useful information on strategies for the design of efficient and safe regenerative medicine materials.

Keywords

tumor suppressor / chemical functional group / co-culture system / regenerative medicine material

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Acknowledgements

This work was in part supported by a grant from the National Basic Research Program of China (Grant No. 2011CB606205).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg