Preparation and application of highly porous aerogel-based bioactive materials in dentistry

Abstract

In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and β-tricalcium phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in the mesoporous region with a maximum pore diameter of 7.4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scanning electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy.

Keywords

aerogel / sol-gel technique / bioactive material / SAOS-2 cell

References

[1] LázárI, ManóS, JónásZ, Mesoporous silica-calcium phosphate composites for experimental bone substitution. Biomechanica Hungarica, 2010, III.1: 151-158

[2] DorozhkinS V. Calcium orthophosphates in dentistry. Journal of Materials Science: Materials in Medicine, 2013, 24(6): 1335-1363

[3] DorozhkinS V. Calcium orthophosphate cements for biomedical application. Journal of Materials Science, 2008, 43(9): 3028-3057

[4] DorozhkinS V. Biphasic, triphasic and multiphasic calcium orthophosphates. Acta Biomaterialia, 2012, 8(3): 963-977

[5] MonchauF, HivartP, GenesiteB, . Calcite as a bone substitute.Comparsion with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity. Materials Science and Engineering C, 2013, 33(1): 490-498

[6] HenchL L. Bioceramics. Journal of the American Ceramic Society, 1998, 81(7): 1705-1728

[7] GittingsJ P, BowenC R, DentA C, . Electrical characterization of hydroxyapatite-based bioceramics. Acta Biomaterialia, 2009, 5(2): 743-754

[8] RezwanK, ChenQ Z, BlakerJ J, . Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006, 27(18): 3413-3431

[9] HenchL L. Bioceramics: from concept to clinic. Journal of the American Ceramic Society, 1991, 74(7): 1487-1510

[10] SilverI A, DeasJ, ErecińskaM. Interactions of bioactive glasses with osteoblasts in vitro: effects of 45S5 Bioglass^®, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability. Biomaterials, 2001, 22(2): 175-185

[11] OhtsukiC, KamitakaharaM, MiyazakiT. Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration. Journal of the Royal Society, Interface, 2009, 6(Suppl 3): S349-S360

[12] LiuX, MorraM, CarpiA, . Bioactive calcium silicate ceramics and coatings. Biomedicine & Pharmacotherapy, 2008, 62(8): 526-529

[13] LeeE J, ShinD S, KimH E, . Membrane of hybrid chitosan–silica xerogel for guided bone regeneration. Biomaterials, 2009, 30(5): 743-750

[14] BalamuruganA, RebeloA H S, LemosA F, . Suitability evaluation of sol-gel derived Si-substituted hydroxyapatite for dental and maxillofacial applications through in vitro osteoblasts response. Dental Materials, 2008, 24(10): 1374-1380

[15] KarageorgiouV, KaplanD. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26(27): 5474-5491

[16] SingK S V, EverettD H, HaulR A W, . Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity. Pure and Applied Chemistry, 1985, 57(4): 603-619

[17] TuanR S. Role of adult stem/progenitor cells in osseointegration and implant loosening. International Journal of Oral & Maxillofacial Implants, 2011, 26(Suppl): 50-62, discussion 63-69

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg