The development of graphene-based devices for cell biology research

Zhi-Qin YAN, Wei ZHANG

PDF(1656 KB)
PDF(1656 KB)
Front. Mater. Sci. ›› 2014, Vol. 8 ›› Issue (2) : 107-122. DOI: 10.1007/s11706-014-0228-x
REVIEW ARTICLE
REVIEW ARTICLE

The development of graphene-based devices for cell biology research

Author information +
History +

Abstract

Graphene has emerged as a new carbon nanoform with great potential in many applications due to its exceptional physical and chemical properties. Especially, graphene and its derivatives are also gaining a lot of interest in the biomedical field as new components for biosensors, tissue engineering, and drug delivery. This review presents unique properties of graphene, the bio-effects of graphene and its derivatives, especially their interactions with cells and the development of graphene-based biosensors and nanomedicines for cancer diagnosis and treatment.

Keywords

graphene / graphene oxide (GO) / cell / sensor / cancer

Cite this article

Download citation ▾
Zhi-Qin YAN, Wei ZHANG. The development of graphene-based devices for cell biology research. Front. Mater. Sci., 2014, 8(2): 107‒122 https://doi.org/10.1007/s11706-014-0228-x

References

[1]
Novoselov K S, Geim A K, Morozov S V, . Electric field effect in atomically thin carbon films. Science, 2004, 306(5696): 666–669
[2]
Huang X, Qi X Y, Boey F, . Graphene-based composites. Chemical Society Reviews, 2012, 41(2): 666–686
[3]
Gunlycke D, Lawler H M, White C T. Room-temperature ballistic transport in narrow graphene strips. Physical Review B: Condensed Matter and Materials Physics, 2007, 75(8): 085418 (5 pages)
[4]
Novoselov K S, Jiang Z, Zhang Y, . Room-temperature quantum Hall effect in graphene. Science, 2007, 315(5817): 1379
[5]
Zhang Y B, Tan Y W, Stormer H L, . Experimental observation of the quantum Hall effect and Berry’s phase in graphene. Nature, 2005, 438(7065): 201–204
[6]
Nair R R, Blake P, Grigorenko A N, . Fine structure constant defines visual transparency of graphene. Science, 2008, 320(5881): 1308
[7]
Xia F N, Mueller T, Lin Y M, . Ultrafast graphene photodetector. Nature Nanotechnology, 2009, 4(12): 839–843
[8]
Gómez-Navarro C, Burghard M, Kern K. Elastic properties of chemically derived single graphene sheets. Nano Letters, 2008, 8(7): 2045–2049
[9]
Dikin D A, Stankovich S, Zimney E J, . Preparation and characterization of graphene oxide paper. Nature, 2007, 448(7152): 457–460
[10]
Balandin A A, Ghosh S, Bao W Z, . Superior thermal conductivity of single-layer graphene. Nano Letters, 2008, 8(3): 902–907
[11]
Wang Y, Li Z H, Wang J, . Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends in Biotechnology, 2011, 29(5): 205–212
[12]
Ryoo S R, Kim Y K, Kim M H, . Behaviors of NIH-3T3 fibroblasts on graphene/carbon nanotubes: proliferation, focal adhesion, and gene transfection studies. ACS Nano, 2010, 4(11): 6587–6598
[13]
Chang Y, Yang S T, Liu J H, . In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicology Letters, 2011, 200(3): 201–210
[14]
Gurunathan S, Han J W, Eppakayala V, . Biocompatibility of microbially reduced graphene oxide in primary mouse embryonic fibroblast cells. Colloids and surfaces B: Biointerfaces, 2013, 105: 58–66
[15]
Zhang H, Peng C, Yang J Z, . Uniform ultrasmall graphene oxide nanosheets with low cytotoxicity and high cellular uptake. ACS Applied Materials & Interfaces, 2013, 5(5): 1761–1767
[16]
Waiwijit U, Kandhavivorn W, Oonkhanond B, . Cytotoxicity assessment of MDA-MB-231 breast cancer cells on screen-printed graphene–carbon paste substrate. Colloids and surfaces B: Biointerfaces, 2014, 113: 190–197
[17]
Zhang Y, Ali S F, Dervishi E, . Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano, 2010, 4(6): 3181–3186
[18]
Wang K, Ruan J, Song H, . Biocompatibility of graphene oxide. Nanoscale Research Letters, 2011, 6: 8
[19]
Gurunathan S, Han J W, Eppakayala V, . Green synthesis of graphene and its cytotoxic effects in human breast cancer cells. International Journal of Nanomedicine, 2013, 8: 1015–1027
[20]
Jaworski S, Sawosz E, Grodzik M, . In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells. International Journal of Nanomedicine, 2013, 8: 413–420
[21]
Horvath L, Magrez A, Burghard M, . Evaluation of the toxicity of graphene derivatives on cells of the lung luminal surface. Carbon, 2013, 64: 45–60
[22]
Qu G B, Liu S J, Zhang S P, . Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosis in macrophages. ACS Nano, 2013, 7(7): 5732–5745
[23]
Das S, Singh S, Singh V, . Oxygenated functional group density on graphene oxide: its effect on cell toxicity. Particle & Particle Systems Characterization, 2013, 30(2): 148–157
[24]
Kim J A, Åberg C, Salvati A, . Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population. Nature Nanotechnology, 2012, 7(1): 62–68
[25]
Yue H, Wei W, Yue Z G, . The role of the lateral dimension of graphene oxide in the regulation of cellular responses. Biomaterials, 2012, 33(16): 4013–4021
[26]
Makharza S, Cirillo G, Bachmatiuk A, . Size-dependent nanographene oxide as a platform for efficient carboplatin release. Journal of Materials Chemistry B, 2013, 1: 6107–6114
[27]
Lammel T, Boisseaux P, Fernandez-Cruz M-L, . Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2. Particle and Fibre Toxicology, 2013, 10: 27
[28]
Corr S J, Raoof M, Cisneros B T, . Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells. Nanoscale Research Letters, 2013, 8: 208
[29]
Wu C, Wang C, Han T, . Insight into the cellular internalization and cytotoxicity of graphene quantum dots. Advanced Healthcare Materials, 2013,
CrossRef Google scholar
[30]
Na H K, Kim M H, Lee J, . Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials. Nanoscale, 2013, 5(4): 1669–1677
[31]
Marconi E, Nieus T, Maccione A, . Emergent functional properties of neuronal networks with controlled topology. PLoS ONE, 2012, 7(4): e34648
[32]
Strong V, Dubin S, El-Kady M F, . Patterning and electronic tuning of laser scribed graphene for flexible all-carbon devices. ACS Nano, 2012, 6(2): 1395–1403
[33]
Lorenzoni M, Brandi F, Dante S, . Simple and effective graphene laser processing for neuron patterning application. Scientific Reports, 2013, 3: 1954
[34]
Tu Q, Pang L, Chen Y, . Effects of surface charges of graphene oxide on neuronal outgrowth and branching. Analyst, 2014, 139(1): 105–115
[35]
Crowder S W, Prasai D, Rath R, . Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells. Nanoscale, 2013, 5(10): 4171–4176
[36]
Akhavan O, Ghaderi E, Shahsavar M. Graphene nanogrids for selective and fast osteogenic differentiation of human mesenchy-mal stem cells. Carbon, 2013, 59: 200–211
[37]
Ku S H, Park C B. Myoblast differentiation on graphene oxide. Biomaterials, 2013, 34(8): 2017–2023
[38]
Lv M, Zhang Y, Liang L, . Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line. Nanoscale, 2012, 4(13): 3861–3866
[39]
Li N, Zhang Q, Gao S, . Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Scientific Reports, 2013, 3: 1604
[40]
Akhavan O, Ghaderia E. Differentiation of human neural stem cells into neural networks on graphene nanogrids. Journal of Materials Chemistry B, 2013, 1(45): 6291–6301
[41]
Park S Y, Park J, Sim S H, . Enhanced differentiation of human neural stem cells into neurons on graphene. Advanced Materials, 2011, 23(36): H263–H267
[42]
Castillo J J, Svendsen W E, Rozlosnik N, . Detection of cancer cells using a peptide nanotube-folic acid modified graphene electrode. Analyst, 2013, 138(4): 1026–1031
[43]
Guo C X, Ng S R, Khoo S Y, . RGD-peptide functionalized graphene biomimetic live-cell sensor for real-time detection of nitric oxide molecules. ACS Nano, 2012, 6(8): 6944–6951
[44]
Zhang B, Li Q, Cui T H. Ultra-sensitive suspended graphene nanocomposite cancer sensors with strong suppression of electrical noise. Biosensors & Bioelectronics, 2012, 31(1): 105–109
[45]
Cohen-Karni T, Qing Q, Li Q, . Graphene and nanowire transistors for cellular interfaces and electrical recording. Nano Letters, 2010, 10(3): 1098–1102
[46]
He Q Y, Sudibya H G, Yin Z Y, . Centimeter-long and large-scale micropatterns of reduced graphene oxide films: fabrication and sensing applications. ACS Nano, 2010, 4(6): 3201–3208
[47]
Kim D J, Sohn I Y, Jung J H, . Reduced graphene oxide field-effect transistor for label-free femtomolar protein detection. Biosensors and Bioelectronics, 2013, 41: 621–626
[48]
Liu Z M, Guo Z Y, Zhong H Q, . Graphene oxide based surface-enhanced Raman scattering probes for cancer cell imaging. Physical Chemistry Chemical Physics, 2013, 15(8): 2961–2966
[49]
Hu C F, Liu Y L, Qin J L, . Fabrication of reduced graphene oxide and sliver nanoparticle hybrids for Raman detection of absorbed folic acid: a potential cancer diagnostic probe. ACS Applied Materials & Interfaces, 2013, 5(11): 4760–4768
[50]
Liu Q H, Wei L, Wang J Y, . Cell imaging by graphene oxide based on surface enhanced Raman scattering. Nanoscale, 2012, 4(22): 7084–7089
[51]
Pan D, Zhang J, Li Z, . Hydrothermal route for cutting graphene sheets into blue-luminescent graphene quantum dots. Advanced Materials, 2010, 22(6): 734–738
[52]
Zhu S, Tang S, Zhang J, . Control the size and surface chemistry of graphene for the rising fluorescent materials. Chemical Communications, 2012, 48(38): 4527–4539
[53]
Zhang X, Wang S, Liu M, . Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications. Physical Chemistry Chemical Physics, 2013, 15(43): 19013–19018
[54]
Sheng Y, Tang X S, Peng E W, . Graphene oxide based fluorescent nanocomposites for cellular imaging. Journal of Materials Chemistry B, 2013, 1(4): 512–521
[55]
Chen M L, He Y J, Chen X W, . Quantum-dot-conjugated graphene as a probe for simultaneous cancer-targeted fluorescent imaging, tracking, and monitoring drug delivery. Bioconjugate Chemistry, 2013, 24(3): 387–397
[56]
Yue Z G, Lv P P, Yue H, . Inducible graphene oxide probe for high-specific tumor diagnosis. Chemical Communications, 2013, 49(37): 3902–3904
[57]
Yoon H J, Kim T H, Zhang Z, . Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nature Nanotechnology, 2013, 8: 735–741
[58]
Sheng Z H, Song L, Zheng J X, . Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials, 2013, 34(21): 5236–5243
[59]
Tang L A L, Wang J Z, Lim T K, . High-performance graphene–titania platform for detection of phosphopeptides in cancer cells. Analytical Chemistry, 2012, 84(15): 6693–6700
[60]
Mao X W, Li H B. Chiral imaging in living cells with functionalized graphene oxide. Journal of Materials Chemistry B, 2013, 1(34): 4267–4272
[61]
Liu Z, Robinson J T, Sun X M, . PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. Journal of the American Chemical Society, 2008, 130(33): 10876–10877
[62]
Yang X Y, Zhang X Y, Liu Z F, . High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. Journal of Physical Chemistry C, 2008, 112(45): 17554–17558
[63]
Wu J, Wang Y S, Yang X Y, . Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology, 2012, 23(35): 355101
[64]
Zhi F, Dong H F, Jia X F, . Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS ONE, 2013, 8(3): e60034
[65]
Chang Y L, Yang S T, Liu J H, . In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicology Letters, 2011, 200(3): 201–210
[66]
Liu J-H, Yang S-T, Wang H-F, . Effect of size and dose on the biodistribution of graphene oxide in mice. Nanomedicine, 2012, 7(12): 1801–1812
[67]
Jin R, Ji X J, Yang Y X, . Self-assembled graphene-dextran nanohybrid for killing drug-resistant cancer cells. ACS Applied Materials & Interfaces, 2013, 5(15): 7181–7189
[68]
Wang C, Wu C Y, Zhou X J, . Enhancing cell nucleus accumulation and DNA cleavage activity of anti-cancer drug via graphene quantum dots. Scientific Reports, 2013, 3: 2852
[69]
Qin X C, Guo Z Y, Liu Z M, . Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy. Journal of Photochemistry and Photobiology B: Biology, 2013, 120: 156–162
[70]
Wang Y W, Fu Y Y, Peng Q L, . Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging. Journal of Materials Chemistry B, 2013, 1(42): 5762–5767
[71]
Wu S W, Han G, Milliron D J, . Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(27): 10917–10921
[72]
Zhou J, Liu Z, Li F Y. Upconversion nanophosphors for small-animal imaging. Chemical Society Reviews, 2012, 41(3): 1323–1349
[73]
Wang Y, Wang H, Liu D, . Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy. Biomaterials, 2013, 34(31): 7715–7724

Acknowledgements

We thank the National Natural Science Foundation of China (Grant No. 51373043) for funding.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
AI Summary AI Mindmap
PDF(1656 KB)

Accesses

Citations

Detail

Sections
Recommended

/