The role of hyaluronic acid in biomineralization

Zhen-Hua CHEN1,2(), Xiu-Li REN1, Hui-Hui ZHOU3, Xu-Dong LI2()

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Front. Mater. Sci. ›› 2012, Vol. 6 ›› Issue (4) : 283-296. DOI: 10.1007/s11706-012-0182-4
REVIEW ARTICLE

The role of hyaluronic acid in biomineralization

  • Zhen-Hua CHEN1,2(), Xiu-Li REN1, Hui-Hui ZHOU3, Xu-Dong LI2()
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Abstract

Hyaluronic acid has been extensively investigated due to intrinsic properties of natural origin and strong ability to bind ions in water. Hyaluronic acid is an excellent crystal modifier because its abundant negatively charged carboxyl groups can bind the cations protruding from the crystal lattice. In this review, we mainly present the latest work focus on the role of hyaluronic acid in controlling the crystallization, breaking the symmetry of crystal, and the surface funtionalization of nanocrystals.

Keywords

hyaluronic acid / biomineralization / crystal growth / extracellular matrix / bone and cartilage repair

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Zhen-Hua CHEN, Xiu-Li REN, Hui-Hui ZHOU, Xu-Dong LI. The role of hyaluronic acid in biomineralization. Front Mater Sci, 2012, 6(4): 283‒296 https://doi.org/10.1007/s11706-012-0182-4

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