Interactions between neural stem cells and biomaterials combined with biomolecules

Abstract

Neural repair and regeneration have been a tough problem in clinical studies. Tissue engineering using biomaterials along with neural stem cells (NSCs) have shown great potential for treatment, especially along with the biomolecules to regulate the NSCs can get more promising results. The biomolecules in the materials have a favorable impact on cell adhes ion, expansion, and differentiation. Thus, the interactions between biomaterials loading biomolecules and NSCs also receive particular attention. In this review, recent progresses of modified biomaterials by such biomolecules for neural injury and their impact on NSCs behavior will be discussed.

Keywords

biomaterial / neural stem cell (NSC) / tissue engineering / biomolecule

References

[1] Subramanian A, Krishnan U M, Sethuraman S. Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration. Journal of Biomedical Science, 2009, 16(1): 108

[2] Barnabé-Heider F, Miller F D. Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. Journal of Neuroscience, 2003, 23(12): 5149–5160

[3] Islam O, Loo T X, Heese K. Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways. Current Neurovascular Research, 2009, 6(1): 42–53

[4] Yaghoobi M M, Mahani M T. NGF and BDNF expression drop off in neurally differentiated bone marrow stromal stem cells. Brain Research, 2008, 1203: 26–31

[5] Lachyankar M B, Condon P J, Quesenberry P J, . Embryonic precursor cells that express Trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF. Experimental Neurology, 1997, 144(2): 350–360

[6] Schmidt M H H, Bicker F, Nikolic I, . Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nature Cell Biology, 2009, 11(7): 873–880

[7] Moon B S, Yoon J Y, Kim M Y, . Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway. Experimental & Molecular Medicine, 2009, 41(2): 116–125

[8] Zunszain P, Anacker C, Carvalho L, . The role of pro-inflammatory cytokines IL-ip and IL-6 on proliferation of human hippocampal neural stem cells. European Neuropsychopharmacolo-gy, 2009, 19(Supplement 3): S275

[9] Paik J H, Ding Z H, Narurkar R, . FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell, 2009, 5(5): 540–553

[10] Lountos G T, Tropea J E, Zhang D, . Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Science, 2009, 18(1): 92–100

[11] Mondal D, Pradhan L, LaRussa V F. Signal transduction pathways involved in the lineage-differentiation of NSCs: can the knowledge gained from blood be used in the brain? Cancer Investigation, 2004, 22(6): 925–943

[12] Ren Y J, Zhang H, Huang H, . In vitro behavior of neural stem cells in response to different chemical functional groups. Biomaterials, 2009, 6(30): 1036–1044

[13] Doetsch F, Petreanu L, Caille I, . EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron, 2002, 36(6): 1021–1034

[14] Mira H, Andreu Z, Suh H, . Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell, 2010, 7(1): 78–89

[15] Huang Y S, Cheng S N, Chueh S H, . Effects of interleukin-15 on neuronal differentiation of neural stem cells. Brain Research, 2009, 1304: 38–48

[16] Islam O, Gong X, Rose-John S, . Interleukin-6 and neural stem cells: more than gliogenesis. Molecular Biology of the Cell, 2009, 20(1): 188–199

[17] Martin I, Andres C R, Védrine S, . Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells. Brain Research, 2009, 1284: 22–30

[18] Su L, Lv X, Xu J P, . Neural stem cell differentiation is mediated by integrin β4 in vitro. The International Journal of Biochemistry & Cell Biology, 2009, 41(4): 916–924

[19] Chen C R, Li Y C, Young T H. Gallium nitride induces neuronal differentiation markers in neural stem/precursor cells derived from rat cerebral cortex. Acta Biomaterialia, 2009, 5(7): 2610–2617

[20] Ren Y J, Zhang H, Huang H, . In vitro behavior of neural stem cells in response to different chemical functional groups. Biomaterials, 2009, 30(6): 1036–1044

[21] Kerrigan J J, Mansell J P, Sandy J R. Matrix turnover. Journal of Orthodontics, 2000, 27(3): 227–233

[22] Guo B-F, Dong M-M. Application of neural stem cells in tissue-engineered artificial nerve. Otolaryngology - Head and Neck Surgery, 2009, 140(2): 159–164

[23] Lin H J, O’Shaughnessy T J, Kelly J, . Neural stem cell differentiation in a cell-collagen-bioreactor culture system. Developmental Brain Research, 2004, 153(2): 163–173

[24] Yang Z Y, Qiao H, Li X G. Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior. Science China - Life Sciences, 2010, 53(4): 504–510

[25] Zhang H, Wei Y T, Tsang K S, . Implantation of neural stem cells embedded in hyaluronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model. Journal of Translational Medicine, 2008, 6(1): 67 (11 pages)

[26] Mi F-L, Shyu S-S, Peng C-K, . Fabrication of chondroitin sulfate-chitosan composite artificial extracellular matrix for stabilization of fibroblast growth factor. Journal of Biomedical Materials Research Part A, 2006, 76A(1): 1–15

[27] Walker P A, Aroom K R, Jimenez F, . Advances in progenitor cell therapy using scaffolding constructs for central nervous system injury. Stem Cell Reviews and Reports, 2009, 5(3): 283–300

[28] Cooke M J, Zahir T, Phillips S R, . Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins. Journal of Biomedical Materials Research. Part A, 2010, 93(3): 824–832

[29] Hwang N S, Varghese S, Elisseeff J. Controlled differentiation of stem cells. Advanced Drug Delivery Reviews, 2008, 60(2): 199–214

[30] Adamia S, Maxwell C A, Pilarski L M. Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer. Current Drug Targets - Cardiovascular & Haematological Disorders, 2005, 5(1): 3–14

[31] Hou S, Tian W, Xu Q, . The enhancement of cell adherence and inducement of neurite outgrowth of dorsal root ganglia co-cultured with hyaluronic acid hydrogels modified with Nogo-66 receptor antagonist in vitro. Neuroscience, 2006, 137(2): 519–529

[32] Tian W M, Zhang C L, Hou S P, . Hyaluronic acid hydrogel as Nogo-66 receptor antibody delivery system for the repairing of injured rat brain: in vitro. Journal of Controlled Release, 2005, 102(1): 13–22

[33] Hu J G, Deng L X, Wang X F, . Effects of extracellular matrix molecules on the growth properties of oligodendrocyte progenitor cells in vitro. Journal of Neuroscience Research, 2009, 87(13): 2854–2862

[34] Hou S P, Xu Q Y, Tian W M, . The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin. Journal of Neuroscience Methods, 2005, 148(1): 60–70

[35] Philp D, Chen S S, Fitzgerald W, . Complex extracellular matrices promote tissue-specific stem cell differentiation. Stem Cells, 2005, 23(2): 288–296

[36] Deguchi K, Tsuru K, Hayashi T, . Implantation of a new porous gelatin-siloxane hybrid into a brain lesion as a potential scaffold for tissue regeneration. Journal of Cerebral Blood Flow and Metabolism, 2006, 26(10): 1263–1273

[37] Miyazaki H, Kato K, Teramura Y, . A collagen-binding mimetic of neural cell adhesion molecule. Bioconjugate Chemistry, 2008, 19(6): 1119–1123

[38] Zhang X M, Huang G W, Tian Z H, . Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells. Nutritional Neuroscience, 2009, 12(5): 226–232

[39] Yabe T, Hirahara H, Harada N, . Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo. Neuroscience, 2010, 165(2): 515–524

[40] Nan G X, Li M, Liao W H, . Effect of valproic acid on endogenous neural stem cell proliferation in a rat model of spinal cord injury. Neural Regeneration Research, 2009, 4(7): 513–517

[41] Tabopda T K, Ngoupayo J, Liu J W, . Induction of neuronal differentiation in neurosphere stem cells by ellagic acid derivatives. Natural Product Communications, 2009, 4(4): 517–520

[42] Nakaji-Hirabayashi T, Kato K, Iwata H. Hyaluronic acid hydrogel loaded with genetically-engineered brain-derived neurotrophic factor as a neural cell carrier. Biomaterials, 2009, 30(27): 4581–4589

[43] Katakura M, Hashimoto M, Shahdat H M, . Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Neuroscience, 2009, 160(3): 651–660

[44] Guo G Q, Li B, Wang Y Y, . Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice. Science China: Life Sciences, 2010, 53(6): 653–662

[45] Willenberg B J, Hamazaki T, Meng F W, . Self-assembled copper-capillary alginate gel scaffolds with oligochitosan support embryonic stem cell growth. Journal of Biomedical Materials Research Part A, 2006, 79A(2): 440–450

[46] Sharma R, Greenhough S, Medine C N, . Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction. Journal of Biomedicine and Biotechnology, 2010, 2010: 236147 (12 pages)

[47] Leor J, Gerecht S, Cohen S, . Human embryonic stem cell transplantation to repair the infarcted myocardium. Heart, 2007, 93(10): 1278–1284

[48] Li X G, Yang Z Y, Zhang A. The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials, 2009, 30(28): 4978–4985

[49] Guo B F, Dong M M. Application of neural stem cells in tissue-engineered artificial nerve. Otolaryngology - Head and Neck Surgery, 2009, 140(2): 159–164

[50] Leipzig N D, Xu C C, Zahir T, . Functional immobilization of interferon-gamma induces neuronal differentiation of neural stem cells. Journal of Biomedical Materials Research Part A, 2010, 93(2): 625–633

[51] Xu X Y, Li X T, Peng S W, . The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber scaffolds. Biomaterials, 2010, 31(14): 3967–3975

[52] Namba R M, Cole A A, Bjugstad K B, . Development of porous PEG hydrogels that enable efficient, uniform cell-seeding and permit early neural process extension. Acta Biomaterialia, 2009, 5(6): 1884–1897

[53] Lampe K J, Mooney R G, Bjugstad K B, . Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture. Journal of Biomedical Materials Research Part A, 2010, 94(4): 1162–1171

[54] Ananthanarayanan B, Little L, Schaffer D V, . Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. Biomaterials, 2010, 31(33): 8706–8715

[55] Song Y L, Zheng Q X, Wu Y C, . Two-dimensional effects of hydrogel self-organized from IKVAV-containing peptides on growth and differentiation of NSCs. Journal of Wuhan University of Technology - Materials Science Edition, 2009, 24(2): 186–192

[56] Bible E, Chau D Y, Alexander M R, . The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. Biomaterials, 2009, 30(16): 2985–2994

[57] Horne M K, Nisbet D R, Forsythe J S, . Three-dimensional nanofibrous scaffolds incorporating immobilized BDNF promote proliferation and differentiation of cortical neural stem cells. Stem Cells and Development, 2010, 19(6): 843–852

[58] Lam H J, Patel S, Wang A, . In vitro regulation of neural differentiation and axon growth by growth factors and bioactive nanofibers. Tissue Engineering Part A, 2010, 16(8): 2641–2648

Acknowledgements

We thank the National Basic Research Program of China (Grant Nos. 2005CB623905 and 2011CB606205) and NSFC (Grant Nos. 50973052 and 3091112049) for support of funding.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg