Preparation and comparison study of hydroxyapatite and Eu-hydroxyapatite

Abstract

Hydroxyapatite (HA) is the main component of inorganic minerals in animal sclerous tissues. Nano HA has been used as an inorganic drug for many years in laboratories. In this paper, nano HA was at first synthesized by the coprecipitation method. The element europium was then doped to HA to obtain a new kind of product with fluorescence. Both products of doped and of non-doped HA were analyzed by IR, XRD, TEM and fluorescence microscope. It was proven that Eu-HA had fluorescence.

Keywords

hydroxyapatite (HA) / nanometer / europium / dope

References

[1] Li S P. Introduction of Biomedical Materials. Wuhan: Wuhan University of Technology Press, 2000 (in Chinese)

[2] Hideki A. Hydroxyapatite. Tokyo: Japanese Association of Apatite Science, 1998

[3] Szymura-Oleksiak J, Slosarczyk A, Cios A, . The kinetics of pentoxifylline release in vivo from drug-loaded hydroxyapatite implants. Ceramics International, 2001, 27(7): 767-772

[4] Itokazu M, Esaki M, Yamamoto K, . Local drug delivery system using ceramics: vacuum method for impregnating a chemotherapeutic agent into a porous hydroxyapatite block. Journal of Materials Science: Materials in Medicine, 1999, 10(4): 249-252

[5] Li S P, Zhang S C, Chen W J, . Effects of hydroxyapatite ultrafine powder on colony formation and cytoskeletons of MGC-803 cell. Bioceramics, 1996, 9: 225-227 (in Chinese)

[6] Wang Y F, Yan Y H, Ren W, . Preparation and characterization of nano hydroxyapatite sol. Transactions of Nonferrous Metals Society of China, 2004, 14(1): 29-32 (in Chinese)

[7] Feng L Y, Li S P. Inhibition of HAP nanoparticles on W-256 Sarcoma of rats in vivo. Chinese Journal of Biomedical Engineering, 2001, 10: 302-305 (in Chinese)

[8] Sun E J, Li S P. Selective inhibition of hepatocarcinomal cells by apatite nanoparticles. Chinese Journal of Biomedical Engineering, 2002, 11(2): 67-71 (in Chinese)

[9] Slosarczyk A, Stobierska E, Paszkiewicz Z, . Calcium phosphate materials prepared from precipitates with various calcium: phosphorus Molar Ratios. Juurnal of the American Ceramic Society, 1996, 79(10): 2539-2544

[10] Liu C S, Huang Y, Shen W, . Kinetics of hydroxyapatite precipitation at pH 10–11. Biomaterials, 2001, 22: 301-306 (in Chinese)

[11] Lazic S, Zec S, Miljevic N, . The effect of temperature on the properities of hydroxyapatite precipitated from calcium hydroxide and phosphoric acid. Thermochimica Acta, 2001, 374: 13-22

[12] Bouyer E, Gitzhofer F, Boulos M I. Morphological study of hydroxyapatite nanocrytal suspension. Journal of Materials Science: Materials inMedicine, 2000, 11: 523-531

[13] Rao R R, Rooph H N, Kannan S T, . Solid state synthesis and thermal stability of Hap and HAP-B-Tcp composite ceramic powders. Journal of Materials Science: Materials in Medicine, 1997, 8: 511-518

[14] Fujishiro Y, Yabuki H, Kawamura M, . Preparation of needle-like apatite hydroxyapatite by homogeneous precipitation under hydrothermal conditions. Journal of Chemical Technology and Biotechnology, 1993, 57: 349-353

[15] Wang Y F, Yan Y H, Liang F. Preparation of needle-like hydroxyapatite single crystal by homogeneous precipitation method under hydrothermal condition. Silicate Bulletin, 2001, 20(2): 30-33 (in Chinese)

[16] Layrolle P, Ito A, Tateishi T. Sol-gelsynthesis of amorphous calcium phosphate and sintering into microporous hydroxyapatite bioceramics. Journal of the American Ceramic Society, 1998, 81(6): 1421-1428

[17] Song Y J, Li M S, Wen S L. Effect of temperature and pH value on the preparation of hydroxyapatite powder. Silicate Bulletin, 2003, 2: 7-10 (in Chinese)

[18] Kano S, Yamazaki A, Otsuka R, . Application of hydroxyapatite-sol as drug carrier. Bio-Medical Materials and Engineering, 1994, 4(4): 283-290

[19] Feng L Y, Li S P, Chen W J. preparation of hydroxyapatite-sol and its effect on Proliferation of tumour cells. The Chinese Journal of Nonferrous Metals, 1999, 9(3): 651-654 (in Chinese)

[20] Liao Q L, Xu G L, Yin G F, . Hydrothermal synthesis of nano hydroxyapatite crystals. Functional Materials, 2002, 33(3): 338-340 (in Chinese)

RIGHTS & PERMISSIONS

Higher Education Press and Springer-Verlag Berlin Heidelberg