Usage of polymer brushes as substrates of bone cells

Abstract

Implant medical research and tissue engineering both target the design of novel biomaterials for the improvement of human health and clinical applications. In order to develop improved surface coatings for hard tissue (bone) replacement materials and implant devices, we are developing micropatterned coatings consisting of polymer brushes. These are used as organic templates for the mineralization of calcium phosphate in order to improve adhesion of bone cells. First, we give a short account of the current state-of-the-art in this particular field of biomaterial development, while in the second part the preliminary results of cell culture experiments are presented, in which the biocompatibility of polymer brushes are tested on human mesenchymal stem cells.

Keywords

polymer brush / ATRP / micropatterning / bone cell / cell adhesion

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Acknowledgements

This work was financially supported by the Deutsche Forschungsgemeinschaft (DFG-SPP 1117 “Principles of Biomineralisation”) and Landesstiftung Baden-Württemberg (“Bioaktive multifunktionale Coatings für humanmedizinische Hartgewebeimplantate”). The authors also thank Kohn and Kusterer from the Institute of Electron Devices and Circuits, Ulm University, Kreja and Tautzenberger from the Institute of Orthopaedic Research and Biomechanics, Ulm University.

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