Effect of micro-characterization on thrombus formation ability of TiO film

Abstract

The thrombus formation ability of a biomedical microcoil for hemangioma treatment is one of the basic requirements in clinical intervention application. Surface modification of a biomedical microcoil can improve its thrombus formation ability. In this work, TiO₂ films were deposited using the unbalanced magnetron sputtering method. The structures, components and micro-morphologies of the films were investigated by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM), and scanning electron microscope (SEM). The thrombus formation ability of the films was studied by in vitro platelet adhesion test. The results indicated that a certain characteristic TiO₂ film has the ability to increase thrombus formation. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells (HUVECs) onto different films was investigated by an in vitro HUVECs cultured experiment. The results showed that endothelial cells on certain TiO₂ film surfaces have good adherence, growth and proliferation. Additionally, the relationship between the micro-characterization and biological properties of TiO₂ films is discussed.

Keywords

unbalanced magnetron sputtering / TiO₂ film / platelets / endothelial cells