Immobilizing collagen type I to TiO film for improvement of biocompatibility

Abstract

In this work, using a bio-chemical modification method, collagen type I was immobilized on the TiO₂ film surface by a silane coupling reagent of aminopropyltriethoxysilane. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were used to investigate the characteristics of the modified TiO₂ film. The thrombus formation ability of the films was studied by in vitro platelet adhesion test. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells (HUVECs) onto different films was investigated by in vitro HUVECs cultured experiment. The results show that the modification can improve the biocompatibility of TiO₂ film for applications of biomedical microcoil hemangioma treatment, etc.

Keywords

collagen type I / TiO₂ film / platelets / endothelial cells