Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

CUI Sheng; SHEN Xiaodong; LIN Benlan; SHI Ruihua; CHEN Ping

doi:10.1007/s11706-007-0070-5

Front. Mater. Sci. ›› 2007, Vol. 1 ›› Issue (4) :383 -387. DOI: 10.1007/s11706-007-0070-5

Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

CUI Sheng¹, SHEN Xiaodong¹, LIN Benlan¹, SHI Ruihua², CHEN Ping²

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Abstract

The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe₃O₄ nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paclitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.

Keywords

magnetic materials, electron microscopy, oxides

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CUI Sheng, SHEN Xiaodong, LIN Benlan, SHI Ruihua, CHEN Ping. Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles. Front. Mater. Sci., 2007, 1(4): 383-387 DOI:10.1007/s11706-007-0070-5