Optical monitoring of tissue viability parameters in vivo : from experimental animals to clinical applications

Abstract

Optical monitoring of tissue physiological and biochemical parameters in real-time is a new approach and a powerful tool for better clinical diagnosis and treatment. Most of the devices available for monitoring patients in critical conditions provide information on body respiratory and hemodynamic functions. Currently, monitoring of patients at the cellular and tissue level is very rare. Real-time monitoring of mitochondrial nicotinamide adenine dinucleotide (NADH) as an indicator of intra-cellular oxygen levels started 50 years ago. Mitochondrial dysfunction was recognized as a key element in the pathogenesis of various illnesses. We developed the “CritiView”