2019 novel coronavirus outbreak: a quiz or final exam?

Abstract

The 2019 novel coronavirus (2019-nCoV) is an emerging pathogen and is threatening the global health. Strikingly, more than 28 000 cases and 550 deaths have been reported within two months from disease emergence. Armed with experience from previous epidemics in the last two decades, clinicians, scientists, officials, and citizens in China are all contributing to the prevention of further 2019-nCoV transmission. Efficient preliminary work has enabled us to understand the basic characteristics of 2019-nCoV, but there are still many unanswered questions. It is too early now to judge our performance in this outbreak. Continuous and strengthened efforts should be made not only during the epidemic, but also afterwards in order to prepare for any incoming challenges.

Keywords

2019-nCoV / novel coronavirus / epidemic / public response

References

[1] National Health Commission of China. The latest information for 2019 novel coronavirus infected pneumonia by Feb 5, 2020. 2020. in Chinese) (accessed February 6, 2020)

[2] World Health Organization. Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. accessed February 4, 2020)

[3] Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020 Jan 24. [Epub ahead of print] doi:10.1016/S0140-6736(20)30154-9

[4] World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. accessed February 4, 2020)

[5] World Health Organization. Pandemic (H1N1) 2009—update 112. accessed February 4, 2020)

[6] World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV) – Republic of Korea.accessed February 4, 2020)

[7] World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). accessed February 4, 2020)

[8] Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY , Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL. The genome sequence of the SARS-associated coronavirus. Science 2003; 300(5624): 1399–1404

[9] Zumla A, Chan JF, Azhar EI, Hui DS, Yuen KY. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov 2016; 15(5): 327–347

[10] Xu J, Jia W, Wang P, Zhang S, Shi X, Wang X, Zhang L. Antibodies and vaccines against Middle East respiratory syndrome coronavirus.Emerg Microbes Infect 2019; 8(1): 841–856

[11] Ministry of Finance of the People’s Republic of China. The government at all levels continued to increase input and allocated a total of 47 billion yuan for epidemic prevention and control.in Chinese) (accessed February 4, 2020)

[12] Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019.N Engl J Med 2020 Jan 24. [Epub ahead of print] doi: 10.1056/NEJMoa2001017

[13] Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020; 9(1): 221–236

[14] Ren L, Wang Y, Wu Z, Xiang Z, Guo L, Xu T,Jiang Y, Xiong Y, Li Y, Li H, Fan G, Gu X, Xiao Y, Gao H, Xu J, Yang F, Wang X, Wu C, Chen L, Liu Y, Liu B, Yang J, Wang X, Dong J, Li L, Huang C, Zhao J, Hu Y, Cheng Z, Liu L, Qian Z, Qin C, Jin Q, Cao B, Wang J. Identification of a novel bat-origin coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J 2020. [Epub ahead of print] doi: 10.3760/cma.j.issn.0366-6999.2020.00.E001

[15] Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu W J, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020 Jan 30. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30251-8

[16] Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020 Feb 3. [Epub ahead of print] doi: 10.1038/s41586-020-2012-7

[17] Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Li M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JTK, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020 Jan 29. [Epub ahead of print] doi: 10.1056/NEJMoa2001316

[18] Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020 Jan 24. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30183-5

[19] Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020 Jan 30. [Epub ahead of print]doi: 10.1016/S0140-6736(20)30211-7

[20] National Health Commission of China. The issuance of the diagnosis and treatment programme for pneumonia of novel coronavirus infections (pilot fifth edition). 2020. in Chinese) (accessed February 5, 2020)

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