Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of Fuyang city, Anhui province, China

Abstract

The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China. A cross-sectional survey was carried out in two villages where HIV/AIDS prevalence in residents was over 1%. Stool samples of all residents in the two targeted villages were examined for the presence of intestinal parasites. Blood examination was performed for the HIV infection detection and anemia test. A questionnaire survey was carried out in all residents participating in the study. A total of 769 individuals were enrolled in the investigation, 720 of whom were involved in stool examination of intestinal parasites. The infection rates of parasites in the residents of the targeted villages were as follows: 0.56% for Ascaris lumbricoides, 4.03% for Hookworm, 0.28% for Trichuris trichiura, 0.42% for Clonorchis sinensis, 21.39% for Blastocystis hominis, 3.89% for Giardia lamblia, 1.67% for Entamoeba spp., 4.44% for Cryptosporidium spp., and no infection for Strongyloides stercoralis. The overall infection rate of intestinal worms was 4.72%, intestinal parasite infection rate was 24.31%, the anemia prevalence rate was 34.68%, the co-infection rate of HIV and intestinal helminthes 2.17%, the co-infection rate of HIV and intestinal protozoa 28.26%, of which the co-infection rates of HIV and Blastocystis hominis, and HIV and Cryptosporidium spp. were 19.57% and 13.04%, respectively. A significant difference of Cryptosporidium spp. infection rate was found between HIV-positive group (13.04%) and HIV-negative group (4.70%) (P<0.05). Higher prevalence of anemia (34.68%) occurred in the study villages, particularly in children (>50%) and women (>39%). It was concluded that the infection rate of intestinal protozoa in the residents was higher than that of intestinal helminthes in the local setting, and a same pattern appeared in the co-infection rate of HIV and parasites. An interesting finding is that the infection rate of Cryptosporidium spp. among the HIV-positives was significantly higher than that in the HIV-negatives, and children and women had higher anemia prevalence.

Keywords

human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS) / co-infection / intestinal parasites / helminthes / protozoa / China