One of the reasons why HBD technology could not be commercialized is high energy consumption to achieve the required low temperature and high-pressure [
100]. Although many studies focused on studying suitable promoters, surfactants, porous media, and innovative equipment for the HBD technology, few research were conducted on the HBD technology from the perspective of process system engineering to reduce energy consumption. The hydrate formation process is energy-consuming because the formation of hydrate crystals from salt solution requires low-temperature and high-pressure conditions and additional energy [
103]. It is imperative to improve its energy-intensive defects and increase its technical and economic performance. Javanmardi and Moshfeghian [
104] discussed the energy consumption and economic efficiency of the proposed HBD technology. Compared with other desalinations, they found that the HBD technology was more competitive. Long et al. [
105] introduced a novel HBD process based on the improvement of the compression refrigeration cycle and analyzed the energy-intensive and economic performance of the process. The results indicated the yield of freshwater had a significant impact on energy consumption and production costs. As the yield ratio increased, the corresponding total energy consumption and total production costs decreased. However, increasing the yield of freshwater required improving the kinetics and thermodynamic of hydrate formation and choosing appropriate promoters. Deng et al. [
106] used a self-developed double reactor with a storage tank container to conduct different levels of desalination and analyzed the economic and energy consumption of seawater desalination in different processes. Yang et al. [
107] proposed an HBD plant using CO
2 with a compression refrigeration cycle. They analyzed the exergy and energy consumption of the CO
2 HBD unit with the compression refrigeration cycle and found that the exergy loss of the throttling device and the remaining components was 15 kJ/kg and 3–8 kJ/kg, respectively.