Recent progress and prospects in production and identification of umami peptides from marine proteins

Abstract

Umami peptides, the flavor compounds mainly derived from natural proteins, provide a pleasant taste for humans and exhibit a variety of biological activities, such as antioxidant and lipid-lowering properties. Marine proteins, which serve as excellent sources of umami peptides, have become a focal point of research. This review introduces the research progress on reported marine umami peptides. Firstly, it discusses the structural characteristics of umami peptides and the mechanism behind their formation to create an umami taste. It then presents several commonly used techniques for preparing and regulating umami peptides while summarizing the advantages and disadvantages of each technique. Finally, this review describes the potential application prospects for core technologies within Industry 4.0—such as molecular simulation, artificial intelligence, big data analysis, cloud computing, and blockchain technology—which could bring new opportunities for the development of marine umami peptides.

Keywords

Marine umami peptides / Structure characteristics / Tasting mechanism / Preparation / Regulation techniques / Industry 4.0 technology

References

[1] Zhao Y, Zhang M, Devahastin S, Liu Y. Progresses on processing methods of umami substances: A review Trends in Food Science & Technology. 2019, 93, 125-35

[2] Ikeda K. New Seasonings Chemical Senses. 2002, 27, 847-49

[3] Montmayeur J-P, Liberles SD, Matsunami H, Buck LB. A candidate taste receptor gene near a sweet taste locus Nature Neuroscience. 2001, 4, 492-98

[4] Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, et al. Detection of sweet and umami taste in the absence of taste receptor T1r3 Science. 2003, 301, 850-53

[5] Yamaguchi S, Ninomiya K. What is umami Food Reviews International. 1998, 14, 123-38

[6] Lindemann B, Ogiwara Y, Ninomiya Y. The Discovery of Umami Chemical Senses. 2002, 27, 843-44

[7] Hajeb P, Jinap S. Umami taste components and their sources in Asian foods Critical Reviews in Food Science and Nutrition. 2015, 55, 778-91

[8] Chen M, Gao X, Pan D, Xu S, Zhang H, et al. Taste characteristics and umami mechanism of novel umami peptides and umami-enhancing peptides isolated from the hydrolysates of Sanhuang Chicken European Food Research and Technology. 2021, 247, 1633-44

[9] Charoenkwan P, Nantasenamat C, Hasan MM, Moni MA, Manavalan B, et al. UMPred-FRL: a new approach for accurate prediction of umami peptides using feature representation learning International Journal of Molecular Sciences. 2021, 22, 13124

[10] Masic U, Yeomans MR. Umami flavor enhances appetite but also increases satiety The American Journal of Clinical Nutrition. 2014, 100, 532-38

[11] Zhang Y, Venkitasamy C, Pan Z, Liu W, Zhao L. Novel umami ingredients: umami peptides and their taste Journal of Food Science. 2017, 82, 16-23

[12] Cao L, Halpern BS, Troell M, Short R, Zeng C, et al. Vulnerability of blue foods to human-induced environmental change Nature Sustainability. 2023, 6, 1186-98

[13] Liu T, Liang Y, Fan S, et al. Analysis of characteristic taste components of soldier crab ( Mictyris brevidactylus) Food Science. 2018, 14, 236-241

[14] Wang Y, Wang H, Xiang H, Chen S, Zhao Y, et al. Unlocking the opportunities for creating sustainable, flavorful and healthy high-protein "blue foods": Focusing on the impacts of protein-flavor interactions Trends in Food Science & Technology. 2024, 148, 104523

[15] Li X, Xie X, Wang J, Xu Y, Yi S, et al. Identification, taste characteristics and molecular docking study of novel umami peptides derived from the aqueous extract of the clam meretrix meretrix Linnaeus Food Chemistry. 2020, 312, 126053

[16] Alexander LM. Large marine ecosystems: A new focus for marine resources management Marine Policy. 1993, 17, 186-98

[17] Aswani S, Basurto X, Ferse S, Glaser M, Campbell L, et al. Marine resource management and conservation in the Anthropocene Environmental Conservation. 2018, 45, 192-202

[18] Cheung RCF, Ng TB, Wong JH. Marine Peptides: Bioactivities and Applications Marine Drugs. 2015, 13, 4006-4043

[19] Li N, Mahalik NP. A big data and cloud computing specification, standards and architecture: agricultural and food informatics International Journal of Information and Communication Technology. 2019, 14, 159-74

[20] Chen JN, Zhang YY, Huang XH, Dong M, Dong XP, et al. Integrated volatolomics and metabolomics analysis reveals the characteristic flavor formation in Chouguiyu, a traditional fermented mandarin fish of China Food Chemistry. 2023, 418, 135874

[21] Deng X, Lin H, Ahmed I, Sui J. Isolation and identification of the umami peptides from Trachinotus ovatus hydrolysate by consecutive chromatography and Nano-HPLC-MS/MS LWT–Food Science and Technology. 2021, 141, 110887

[22] Qi L, Gao X, Pan D, Sun Y, Cai Z, et al. Research progress in the screening and evaluation of umami peptides Comprehensive Reviews in Food Science and Food Safety. 2022, 21, 1462-90

[23] Zhang J, Zhao M, Su G, Lin L. Identification and taste characteristics of novel umami and umami-enhancing peptides separated from peanut protein isolate hydrolysate by consecutive chromatography and UPLC–ESI–QTOF–MS/MS Food Chemistry. 2019, 278, 674-682

[24] Zhang J, Sun-Waterhouse D, Su G, Zhao M. New insight into umami receptor, umami/umami-enhancing peptides and their derivatives: A review Trends in Food Science & Technology. 2019, 88, 429-43

[25] Chisholm B, Nelson D, Schwarcz H. Marine and terrestrial protein in prehistoric diets on the British Columbia Coast Current Anthropology. 1983, 24, 396-98

[26] Arai S, Yamashita M, Noguchi M, Fujimaki M. Tastes of L-glutamyl oligopeptides in relation to their chromatographic properties Agricultural and Biological Chemistry. 1973, 37, 151-56

[27] Ovchinnikova TV. Marine peptides: structure, bioactivities, and a new hope for therapeutic application Marine Drugs. 2021, 19, 407

[28] Peck LS, Webb KE, Bailey DM. Extreme sensitivity of biological function to temperature in Antarctic marine species Functional Ecology. 2004, 18, 625-30

[29] Spaggiari G, Di Pizio A, Cozzini P. Sweet, umami and bitter taste receptors: State of the art of in silico molecular modeling approaches Trends in Food Science & Technology. 2020, 96, 21-29

[30] Wang W, Cui Z, Ning M, Zhou T, Liu Y. In-silico investigation of umami peptides with receptor T1R1/T1R3 for the discovering potential targets: A combined modeling approach Biomaterials. 2022, 281, 121338

[31] Diepeveen J, Moerdijk-Poortvliet TCW, van der Leij FR. Molecular insights into human taste perception and umami tastants: A review Journal of Food Science. 2022, 87, 1449-65

[32] Wu B, Eldeghaidy S, Ayed C, Fisk ID, Hewson L, et al. Mechanisms of umami taste perception: From molecular level to brain imaging Critical Reviews in Food Science and Nutrition. 2022, 62, 7015-24

[33] Lee BK, Mayhew EJ, Sanchez-Lengeling B, Wei JN, Qian WW, et al. A principal odor map unifies diverse tasks in olfactory perception Science. 2023, 381, 999-1006

[34] Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, et al. Two Distinct Determinants of Ligand Specificity in T1R1/T1R3 (the Umami Taste Receptor)* Journal of Biological Chemistry. 2013, 288, 36863-77

[35] Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, et al. Molecular mechanism for the umami taste synergism Proceedings of the National Academy of Sciences of the United States of America. 2008, 105, 20930-34

[36] San Gabriel A, Uneyama H, Yoshie S, Torii K. Cloning and Characterization of a Novel mGluR1 Variant from Vallate Papillae that Functions as a Receptor for l-glutamate Stimuli Chemical Senses. 2005, 30, i25-i26

[37] Toyono T, Seta Y, Kataoka S, Harada H, Morotomi T, et al. Expression of the Metabotropic Glutamate Receptor, mGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae Archives of Histology and Cytology. 2002, 65, 91-96

[38] Roper SD, Chaudhari N. Taste buds: cells, signals and synapses Nature Reviews Neuroscience. 2017, 18, 485-497

[39] Nango E, Akiyama S, Maki-Yonekura S, Ashikawa Y, Kusakabe Y, et al. Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains Science Report. 2016, 6, 25745

[40] Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, et al. Structural basis for perception of diverse chemical substances by T1r taste receptors Nature Communications. 2017, 8, 15530

[41] Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, et al. Structure of the human TRPM4 ion channel in a lipid nanodisc Science. 2018, 359, 228-32

[42] Liu H, Da LT, Liu Y. Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations Biochemical and Biophysical Research Communications. 2019, 514, 967-73

[43] Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, et al. Structure of the cold- and menthol-sensing ion channel TRPM8 Science. 2018, 359, 237-41

[44] Zhang N, Yang Y, Wang W, Fan Y, Liu Y. A potential flavor seasoning from aquaculture by-products: An example of Takifugu obscurus LWT. 2021, 151, 112160

[45] Diez-Ozaeta I, Astiazaran OJ. Fermented foods: An update on evidence-based health benefits and future perspectives Food Research International. 2022, 156, 111133

[46] Raveschot C, Cudennec B, Coutte F, Flahaut C, Fremont M, et al. Production of bioactive peptides by Lactobacillus species: from gene to application Frontiers Microbiology. 2018, 9, 2354

[47] Yang D, Li C, Li L, Wang Y, Wu Y, et al. Novel insight into the formation mechanism of umami peptides based on microbial metabolism in Chouguiyu, a traditional Chinese fermented fish Food Research International. 2022, 157, 111211

[48] Nasri R, Abdelhedi O, Nasri M, Jridi M. Fermented protein hydrolysates: biological activities and applications Current Opinion in Food Science. 2022, 43, 120-27

[49] Wang W, Zhou X, Liu Y. Characterization and evaluation of umami taste: A review TrAC Trends in Analytical Chemistry. 2020, 127, 115876

[50] Zhang Y, Gao X, Pan D, Zhang Z, Zhou T, et al. Isolation, characterization and molecular docking of novel umami and umami-enhancing peptides from Ruditapes philippinarum Food Chemistry. 2021, 343, 128522

[51] Zhu W, He W, Wang F, Bu Y, Li X, et al. Prediction, molecular docking and identification of novel umami hexapeptides derived from Atlantic cod ( Gadus morhua) International Journal of Food Science & Technology. 2021, 56, 402-12

[52] Wang Y, Luan J, Tang X, Zhu W, Xu Y, et al. Identification of umami peptides based on virtual screening and molecular docking from Atlantic cod ( Gadus morhua) Food Function. 2023, 14, 1510-19

[53] Zhao W, Su L, Huo S, Yu Z, Li J, et al. Virtual screening, molecular docking and identification of umami peptides derived from Oncorhynchus mykiss Food Science and Human Wellness. 2023, 12, 89-93

[54] Zhao S, Ma S, Zhang Y, Gao M, Luo Z, et al. Combining molecular docking and molecular dynamics simulation to discover four novel umami peptides from tuna skeletal myosin with sensory evaluation validation Food Chemistry. 2024, 433, 137331

[55] Xu YX, Qu SY, Li T, Zhao HL, Feng Y, et al. Effects of different proteases on the flavor characteristics of aloididae aloidi muscle hydrolysates Food Science. 2021, 42 4 190-96

[56] Sable R, Parajuli P, Jois S. Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications Marine Drugs. 2017, 15, 124

[57] Fu Y, Liu J, Hansen ET, Bredie WLP, Lametsch R. Structural characteristics of low bitter and high umami protein hydrolysates prepared from bovine muscle and porcine plasma Food Chemistry. 2018, 257, 163-71

[58] Tong X, Lian Z, Miao L, Qi B, Zhang S, et al. An innovative two-step enzyme-assisted aqueous extraction for the production of reduced bitterness soybean protein hydrolysates with high nutritional value LWT. 2020, 134, 110151

[59] Hunsakul K, Laokuldilok T, Sakdatorn V, Klangpetch W, Brennan CS, et al. Optimization of enzymatic hydrolysis by alcalase and flavourzyme to enhance the antioxidant properties of jasmine rice bran protein hydrolysate Scientific Report. 2022, 12, 12582

[60] Zhang XZ, Liang ZL, Pei JW, et al. Preparation of umami enzymatic hydrolysate from squid processing by-products by stepwise dual-enzymatic hydrolysis Food and Fermentation Industries. 2023, 49 15 201-7

[61] Wang YM, Zhang Z, Sheng Y, Chi CF, Wang B. A systematic review on marine umami peptides: Biological sources, preparation methods, structure-umami relationship, mechanism of action and biological activities Food Bioscience. 2024, 57, 103637

[62] Aaslyng MD, Elmore JS, Mottram DS. Comparison of the aroma characteristics of acid-hydrolyzed and enzyme-hydrolyzed vegetable proteins produced from soy Journal of Agricultural and Food Chemistry. 1998, 46, 5225-31

[63] Aaslyng MD, Martens M, Poll L, Nielsen PM, Flyge H, et al. Chemical and sensory characterization of hydrolyzed vegetable protein, a savory flavoring Journal of Agricutral and Food Chemistry. 1998, 46, 481-89

[64] Liu Q, Gao X, Pan D, Liu Z, Xiao C, et al. Rapid screening based on machine learning and molecular docking of umami peptides from porcine bone Journal of the Science of Food and Agriculture. 2023, 103, 3915-25

[65] Li W, Gu Z, Yang Y, Zhou S, Liu Y, et al. Non-volatile taste components of several cultivated mushrooms Food Chemistry. 2014, 143, 427-31

[66] Dai L, Reichert CL, Hinrichs J, Weiss J. Acid hydrolysis behavior of insoluble protein-rich fraction extracted from Chlorella protothecoides Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019, 569, 129-36

[67] Li B, Xie Y, Guo Q. Thermal acid hydrolysis modulates the solubility of quinoa protein: The formation of different types of protein aggregates Food Hydrocolloids. 2024, 151, 109825

[68] Ruan S, Sun L, Sun X, He J, Zhuang Y. Novel umami peptides from tilapia lower jaw and molecular docking to the taste receptor T1R1/T1R3 Food Chemistry. 2021, 362, 130249

[69] Zhang T, Hua Y, Zhou C, Xiong Y, Pan D, et al. Umami peptides screened based on peptidomics and virtual screening from Ruditapes philippinarum and Mactra veneriformis clams Food Chemistry. 2022, 394, 133504

[70] Zhang MX, Wang XC, Liu Y, Xu XL, Zhou GH. Isolation and identification of flavour peptides from Puffer fish ( Takifugu obscurus) muscle using an electronic tongue and MALDI-TOF/TOF MS/MS Food Chemistry. 2012, 135, 1463-70

[71] Liu Z, Zhu Y, Wang W, Zhou X, Chen G, et al. Seven novel umami peptides from Takifugu rubripes and their taste characteristics Food Chemistry. 2020, 330, 127204

[72] Zhang N, Liu H, Zhou X, Wang W, Fan Y, et al. Taste and stability characteristics of two key umami peptides from pufferfish ( Takifugu obscurus) Food Chemistry. 2022, 371, 131124

[73] Zhang Q, Liu R, Geirsdóttir M, Li S, Tomasson T, et al. Thermal-induced autolysis enzymes inactivation, protein degradation and physical properties of sea cucumber, Cucumaria frondosa Processes. 2022, 10, 847

[74] Xue J, Liu P, Feng L, Zheng L, Gui A, et al. Insights into the effects of fixation methods on the sensory quality of straight-shaped green tea and dynamic changes of key taste metabolites by widely targeted metabolomic analysis Food Chemistry: X. 2023, 20, 100943

[75] Wang W, Huang Y, Zhao W, Dong H, Yang J, et al. Identification and comparison of umami-peptides in commercially available dry-cured Spanish mackerels ( Scomberomorus niphonius) Food Chemistry. 2022, 380, 132175

[76] Liang J, Chen L, Li YN, Hu X. Isolation and identification of umami-flavored peptides from Leccinum extremiorientale and their taste characteristic Journal of Food Processing and Preservation. 2021, 45, e15255

[77] Alim A, Yang C, Song H, Liu Y, Zou T, et al. The behavior of umami components in thermally treated yeast extract Food Research International. 2019, 120, 534-43

[78] Shen Q, Sun L, He Z, Xie J, Zhuang Y. Isolation, taste characterization and molecular docking study of novel umami peptides from Lactarius volemus (Fr.) Food Chemistry. 2023, 401, 134137

[79] Wang W, Yang L, Ning M, Liu Z, Liu Y. A rational tool for the umami evaluation of peptides based on multi-techniques Food Chemistry. 2022, 371, 131105

[80] Jin Y, Hu D, Chen Q, Shi C, Ye J, et al. Water-based green and sustainable extraction protocols for value-added compounds from natural resources Current Opinion in Green and Sustainable Chemistry. 2023, 40, 100757

[81] Iqbal M, Tao Y, Xie S, Zhu Y, Chen D, et al. Aqueous two-phase system (ATPS): an overview and advances in its applications Biological Procedures Online. 2016, 18, 18

[82] Wang H, Liu T, Zhao T, Su G, Zhao M, et al. The Umami-enhancing Ability Improvement of Pea Protein Hydrolysate by Maillard Reaction Utilizing Sugar-derived NADES Food and Bioprocess Technology. 2023, 17, 2446-58

[83] Silva I, Vaz BMC, Sousa S, Pintado MM, Coscueta ER, et al. Gastrointestinal delivery of codfish skin-derived collagen hydrolysates: deep eutectic solvent extraction and bioactivity analysis Food Research International. 2024, 175, 113729

[84] Ali MS, Roy VC, Park JS, Haque AR, Mok JH, et al. Protein and polysaccharide recovery from shrimp wastes by natural deep eutectic solvent mediated subcritical water hydrolysis for biodegradable film Marine Biotechnology. 2024

[85] Xu Y, Wang Q, Hou Y. Efficient purification of R-phycoerythrin from marine algae ( Porphyra yezoensis) based on a deep eutectic solvents aqueous two-phase system Marine Drugs. 2020, 18, 618

[86] Mittal R, Sharma R, Raghavarao K. Aqueous two-phase extraction of R-phycoerythrin from marine macro-algae, Gelidium pusillum Bioresource Technology. 2019, 280, 277-86

[87] Bu Y, Liu Y, Luan H, Zhu W, Li X, et al. Characterization and structure–activity relationship of novel umami peptides isolated from Thai fish sauce Food Function. 2021, 12, 5027-37

[88] Jia R, He Y, Wang GY, et al. Recent progress in research on umami peptides in food Meat Researach. 2022, 36, 65-71

[89] Heinzelmann K, Franke K. Using freezing and drying techniques of emulsions for the microencapsulation of fish oil to improve oxidation stability Colloids and Surfaces B: Biointerfaces. 1999, 12, 223-29

[91] Fu H, Feng Q, Qiu D, Shen X, Li C, et al. Improving the flavor of tilapia fish head soup by adding lipid oxidation products and cysteine Food Chemistry. 2023, 429, 136976

[92] Ruan L, Ju Y, Zhan C, Hou L. Improved umami flavor of soy sauce by adding enzymatic hydrolysate of low-value fish in the natural brewing process LWT. 2022, 155, 112911

[93] Abdo H, Sandeep J, Guillermo GG, Hana T, Mirian P, et al. Food quality 4.0: from traditional approaches to digitalized automated analysis Journal of Food Engineering. 2023, 337, 111216

[94] Hassoun A, Alhaj Abdullah N, Aït-Kaddour A, Ghellam M, Beşir A, et al. Food traceability 4.0 as part of the fourth industrial revolution: key enabling technologies Critical Reviews in Food Science and Nutrition. 2024, 64, 873-89

[95] Bai C, Dallasega P, Orzes G, Sarkis J. Industry 4.0 technologies assessment: A sustainability perspective International Journal of Production Economics. 2020, 229, 107776

[96] Dadhaneeya H, Nema PK, Arora VK. Internet of Things in food processing and its potential in Industry 4.0 era: A review Trends in Food Science & Technology. 2023, 139, 104109

[97] Hassoun A, Aït-Kaddour A, Abu-Mahfouz AM, Rathod NB, Bader F, et al. The fourth industrial revolution in the food industry—Part I: Industry 4.0 technologies Critical Reviews in Food Science and Nutrition. 2023, 63, 6547-63

[98] de Oliveira-Dias D, Maqueira-Marin JM, Moyano-Fuentes J, Carvalho H. Implications of using Industry 4.0 base technologies for lean and agile supply chains and performance International Journal of Production Economics. 2023, 262, 108916

[99] Jiang L, Jiang J, Wang X, Zhang Y, Zheng B, et al. IUP-BERT: identification of umami peptides based on BERT features Foods. 2022, 11, 3742

[100] Pallante L, Korfiati A, Androutsos L, Stojceski F, Bompotas A, et al. Toward a general and interpretable umami taste predictor using a multi-objective machine learning approach Scientific Reports. 2022, 12, 21735

[101] Xiong Y, Gao X, Pan D, Zhang T, Qi L, et al. A strategy for screening novel umami dipeptides based on common feature pharmacophore and molecular docking Biomaterials. 2022, 288, 121697

[102] Xiu H, Liu Y, Yang H, Ren H, Luo B, et al. Identification of novel umami molecules via QSAR models and molecular docking Food Functions. 2022, 13, 7529-39

[103] Yu Z, Kang L, Zhao W, Wu S, Ding L, et al. Identification of novel umami peptides from myosin via homology modeling and molecular docking Food Chemistry. 2021, 344, 128728

[104] Wang Y, Liu T, Xie J, Cheng M, Sun L, et al. A review on application of molecular simulation technology in food molecules interaction Current Research in Food Science. 2022, 5, 1873-81

[105] Li C, Hua Y, Pan D, Qi L, Xiao C, et al. A rapid selection strategy for umami peptide screening based on machine learning and molecular docking Food Chemistry. 2023, 404, 134562

[106] Mengucci C, Ferranti P, Romano A, Masi P, Picone G, et al. Food structure, function and artificial intelligence Trends in Food Science & Technology. 2022, 123, 251-63

[107] Zhang J, Yan W, Zhang Q, Li Z, Liang L, et al. Umami-BERT: An interpretable BERT-based model for umami peptides prediction Food Research International. 2023, 172, 113142

[108] Qi L, Du J, Sun Y, Xiong Y, Zhao X, et al. Umami-MRNN: Deep learning-based prediction of umami peptide using RNN and MLP Food Chemistry. 2023, 405, 134935

[109] Cui Z, Zhang N, Zhou T, Zhou X, Meng H, et al. Conserved sites and recognition mechanisms of T1R1 and T2R14 receptors revealed by ensemble docking and molecular descriptors and fingerprints combined with machine learning Journal of Agricultural and Food Chemistry. 2023, 71, 5630-45

[110] Li M, Zhang X, Zhu Y, Zhang X, Cui Z, et al. Identifying umami peptides specific to the T1R1/T1R3 receptor via phage display Journal of Agricutural and Food Chemistry. 2023, 71, 12004-14

[111] Chen Z, Wang R, Guo J, Wang X. The role and future prospects of artificial intelligence algorithms in peptide drug development Biomedicine & Pharmacotherapy. 2024, 175, 116709

[112] Kou X, Shi P, Gao C, Ma P, Xing H, et al. Data-Driven Elucidation of Flavor Chemistry Journal of Agricutural and Food Chemistry. 2023, 71, 6789-802

[113] Oussous A, Benjelloun FZ, Ait Lahcen A, Belfkih S. Big Data technologies: A survey Journal of King Saud University - Computer and Information Sciences. 2018, 30, 431-48

[114] Yaqoob I, Hashem IAT, Gani A, Mokhtar S, Ahmed E, et al. Big data: From beginning to future International Journal of Information Management. 2016, 36, 1231-47

[115] Gradinaru TC, Petran M, Dragos D, Gilca M. PlantMolecularTasteDB: a database of taste active phytochemicals Frontiers in Pharmacology. 2022, 12, 751712

[116] Rojas C, Ballabio D, Pacheco Sarmiento K, Pacheco Jaramillo E, Mendoza M, et al. ChemTastesDB: A curated database of molecular tastants Food Chemistry: Molecular Sciences. 2022, 4, 100090

[117] Zhang W, Ding W, Li YX, Tam C, Bougouffa S, et al. Marine biofilms constitute a bank of hidden microbial diversity and functional potential Nature Communication. 2019, 10, 517

[118] Wan X, Teng Z, Zhang K, Qiu L, Zhang Z, et al. Is quality cost or value-added service cost subsidy: Should the ocean big data supply chain adopt which cost subsidy approach of the government Ocean & Coastal Management. 2023, 242, 106713

[119] Zhou Q, Zhang H, Wang S. Artificial intelligence, big data, and blockchain in food safety International Journal of Food Engineering. 2022, 18, 1-14

[120] Dagar I, Singh G, Singh PK, Maheshwari S. A review on evolution, application and future of cloud computing AIP Conference Proceedings. 2023, 2916, 050004

[121] Pallathadka H, Sajja GS, Phasinam K, Ritonga M, Naved M, et al. An investigation of various applications and related challenges in cloud computing Materials Today: Proceedings. 2022, 51, 2245-48

[122] Kamilaris A, Fonts A, Prenafeta-Boldύ FX. The rise of blockchain technology in agriculture and food supply chains Trends in Food Science & Technology. 2019, 91, 640-52

[123] Guo C, Liu Y, Na M, Song J. Dual-layer index for efficient traceability query of food supply chain based on blockchain Foods. 2023, 12, 2267

[124] Chen H, Zhang P, Li W, Wu M, Li F. An irreversible ultralong-time dependent anti-counterfeiting strategy based on mixed perovskite halogen separation for marine transportation security Journal of Solid State Chemistry. 2023, 326, 124183

[125] She S, Zhu J, Yi K, Wang X. Active response from managers: green marine supply chain empathic response mechanism Ocean & Coastal Management. 2023, 245, 106878

[126] Antonucci F, Figorilli S, Costa C, Pallottino F, Raso L, et al. A review on blockchain applications in the agri-food sector Journal of the Science of Food and Agriculture. 2019, 99, 6129-38

[127] Zhao G, Liu S, Lopez C, Lu H, Elgueta S, et al. Blockchain technology in agri-food value chain management: a synthesis of applications, challenges and future research directions Computers in Industry. 2019, 109, 83-99

[128] Bai W, Liang J, Zhao W, Qian M, Zeng X, et al. Umami and umami-enhancing peptides from myofibrillar protein hydrolysates in low-sodium dry-cured Spanish mackerel ( Scomberomorus niphonius) under the action of Lactobacillus plantarum International Journal of Food Science & Technology. 2022, 57, 5494-503

The authors are grateful to the National Key Research and Development Program of China (2023YFD2100203), the Natural Science Fund of Zhejiang Province (LQ22C200008) and Basic research funds for provincial colleges and universities (FR2401ZD).

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2024 Editorial Office of Food Innovation and Advances