Anti-aging activity and their mechanisms of natural food-derived peptides: current advancements

Abstract

Recently, there has been a growing focus on researching ways to delay aging and protect against age-related illnesses. Small molecular exogenous peptides, sourced from dietary elements like animals, plants, and microorganisms, have demonstrated considerable potential in exerting anti-aging effects. Notably, natural food-derived peptides have exhibited enhanced stability, safety, absorption efficiency, and heightened biological activity. These attributes position them with a greater potential for mitigating aging-related disorders compared to alternative anti-aging drugs or phytochemicals. This review summarizes the origins, structural attributes, and isolation methods of natural food-derived peptides with anti-aging properties. It also explores how these external peptides improve aging-related conditions such as neurodegenerative diseases, skin aging, and metabolic disorders. The underlying mechanisms dictating their impact on well-conserved signaling pathways—encompassing oxidative stress, inflammation, apoptosis, and collagen synthesis—are meticulously elucidated. This paper engages in an insightful exploration of the key challenges and pivotal trajectories, grounded in ongoing research endeavors. As a result, this review is poised to offer authoritative scientific guidance and invaluable support for the practical implementation of natural food-derived peptides in the realm of anti-aging applications within the food, pharmaceutical, and cosmetic industries.

Keywords

Anti-aging / Food-derived peptides / Aging-related diseases / Biological activity / Signaling pathway

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This work was supported by the National Key R & D Program of China (Grant No. 2018YFE0108400) and Guangzhou Science and Technology Plan Project (Grant No. 201903010049) are gratefully acknowledged.

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2023 Editorial Office of Food Innovation and Advances