Research progress on quorum-quenching strategies for membrane biofouling control

Abstract

Membrane biofouling poses a major bottleneck hindering the large-scale application of membrane bioreactors (MBRs). Quorum quenching (QQ) technology, which disrupts bacterial communication, has emerged as a promising strategy for biofouling mitigation. This review comprehensively summarizes QQ mechanisms and strategies, including the inhibition of signal molecule biosynthesis, inactivation of signal molecules, and mimicking of signal molecules. It then details the application of conventional QQ technologies in MBR biofouling control, such as the utilization of QQ enzymes, singular QQ strains, QQ consortia, and genetic engineering QQ bacteria. Advanced QQ technologies and integrated approaches combining QQ with other techniques which greatly enhanced biofouling control efficacy are also introduced. The review critically assesses the advantages and limitations of these technologies. Notably, combining QQ with phage-based methods represents a promising future strategy for membrane biofouling control, leveraging their potential for synergistic interactions. However, the specific synergistic effects and underlying mechanisms require further verification and exploration. Future research should focus on developing novel materials, integrating artificial intelligence for enhanced monitoring and control, and expanding to practical engineering applications to improve the effectiveness and stability of QQ technology for better biofouling control in MBRs.

Graphical abstract

Keywords

Membrane bioreactor (MBR) / Membrane biofouling / Quorum quenching (QQ) / Control technology / Advantages and limitations

Highlight

	● Quorum quenching is a promising membrane fouling control strategy.
	● Quorum quenching technology has shifted from single to synergistic strategies.
	● QQ-phage integration holds promising applications.
	● Future research should focus on the convergence of novel materials and AI.

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