1.No.1 Senior High School,
Muping 264100, China; 2.Institute for Molecular
Bioscience, University of Queensland, Brisbane QLD 4072, Australia; 3.School of Chemical Engineering
and Technology, Tianjin University, Tianjin 300072, China;
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History+
Published Online
2010-09-05
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(417KB)
Abstract
A mouse muscle type nAChR model ((α1)2βδγ) was built based on the cryoelectron microscopic structure of intact Torpedo marmorata nAChR and the high resolution crystal structure of nAChR-α1 subunit. The conformation of the pentameric nAChR model was investigated by molecular dynamic simulation. The function of water molecule in the hydrophilic interior was clarified. The reason for Tyr127 showing two alternative conformations was discussed in detail.
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(417KB)
