Purpose Emerging evidence suggests the involvement of the renin-angiotensin system (RAS) in the pathogenesis and progression of autoimmune dermatological diseases. In a small exploratory study, we investigated angiotensin-converting enzyme (ACE) activity in blood obtained from male probands with psoriasis vulgaris (n = 4) and atopic dermatitis (AD, n = 5).
Methods The degradation capacity of dabsylated synthetic bradykinin (DBK) with and without inhibition was determined using a thin-layer chromatography (TLC)-based neuropeptide reporter assay.
Results We observed a significantly reduced capacity for cleavage of DBK in psoriasis patients compared with that in AD patients and controls. In patient samples, the variation in the measured values was generally greater than that in healthy controls. We could not confirm the increased ACE activity in the circulation in psoriasis patients reported by others, likely because of different study designs and detection methods. We did not include samples of female patients and focused on younger men to avoid hormonal effects and minimize age-related factors.
Conclusion This preliminary study of the hypothesis-generating nature lacks power, but it certainly adds a question to the current view of the role of ACE in psoriasis. Treatments targeting specific components of the RAS could ameliorate inflammatory responses; thus, research in this area is becoming increasingly important.
| [1] |
Silva IMS, Assersen KB, Willadsen NN, et al. . The role of the renin-angiotensin system in skin physiology and pathophysiology. Exp Dermatol., 2020, 29(9): 891-901
|
| [2] |
Flora A, Frew JW. Angiotensin-converting enzyme 2 expression is elevated in tissue of hidradenitis suppurativa and pyoderma gangrenousm and demonstrates a different pattern of expression to psoriasis vulgaris. J Eur Acad Dermatol Venereol., 2023, 37(3): e372-e374
|
| [3] |
Steckelings UM, Artuc M, Wollschläger T, et al. . Angiotensin-converting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol., 2001, 81(5): 321-325
|
| [4] |
Thestrup-Pedersen K. Adverse reactions in the skin from anti-hypertensive drugs. Dan Med Bull., 1987, 34: 3-5
|
| [5] |
Baccino D, Merlo G, Cozzani E, et al. . Cutaneous effects of antihypertensive drugs. G Ital Dermatol Venereol., 2020, 155(2): 202-211
|
| [6] |
Lo Y, Tsai TF. Angiotensin converting enzyme and angiotensin converting enzyme inhibitors in dermatology: a narrative review. Expert Rev Clin Pharmacol., 2022, 15(1): 33-42
|
| [7] |
Abdollahimajd F, Niknezhad N, Haghighatkhah HR, et al. . Angiotensin-converting enzyme and subclinical atherosclerosis in psoriasis: Is there any association A case-control study. J Am Acad Dermatol., 2020, 82(4): 980-981.e1
|
| [8] |
Huskić J, Mulabegović N, Alendar F, et al. . Serum and tissue angiotensin converting enzyme in patients with psoriasis. Coll Antropologicum., 2008, 32(4): 1215-1219
|
| [9] |
Bandeira M, Gil Â, Santos AC, et al. . Angiotensin-converting enzyme activity may predict disease severity in psoriasis. Rheumato., 2022, 2(1): 15-23
|
| [10] |
Ena P, Madeddu P, Rappelli A, et al. . Serum angiotensin-converting enzyme activity in psoriasis. Dermatologica., 1987, 174(3): 110-113
|
| [11] |
Thestrup-Pedersen K, Rømer FK, Jensen JH, et al. . Serum angiotensin-converting enzyme in sarcoidosis and psoriasis. Arch Dermatol Res., 1985, 277(1): 16-18
|
| [12] |
Huskić J, Alendar F. Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis. Bosn J Basic Med Sci., 2007, 7(2): 103-106
|
| [13] |
Ibrahim A, Yousef M, Marei Y, et al. . Angiotensin converting enzyme in psoriasis a comprehensive review. Benha J Appl Sci., 2023, 8(7): 37-42
|
| [14] |
Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, et al. . Serum biomarker profiles suggest that atopic dermatitis is a systemic disease. J Allergy Clin Immunol., 2018, 141(4): 1523-1526
|
| [15] |
Bayer M, König S. A vote for robustness: Monitoring serum enzyme activity by thin-layer chromatography of dabsylated bradykinin products. J Pharm Biomed Anal., 2017, 143: 199-203
|
| [16] |
König S, Bayer M, Dimova V, et al. . The serum protease network—one key to understand complex regional pain syndrome pathophysiology. Pain., 2019, 160(6): 1402-1409
|
| [17] |
König S, Vollenberg R, Tepasse PR. The renin-angiotensin system in COVID-19: can long COVID be predicted Life (Basel). 2023;13(7):1462.
|
| [18] |
Sieminska I, Pieniawska M, Grzywa TM. The immunology of psoriasis-current concepts in pathogenesis. Clin Rev Allergy Immunol., 2024, 66(2): 164-191
|
| [19] |
Chu DK, Koplin JJ, Ahmed T, et al. . How to prevent atopic dermatitis (eczema) in 2024: theory and evidence. J Allergy Clin Immunol Pract., 2024, 12(7): 1695-1704
|
| [20] |
Nwia SM, Leite APO, Li XC, et al. . Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases. Front Cardiovasc Med., 2023, 10: 1198090
|
| [21] |
Schreiber U, Engl C, Bayer M, et al. . Neuropeptide reporter assay for serum, capillary blood and blood cards. MethodsX., 2020, 7 100985
|
| [22] |
Bayer M, Snyder M, König S. The biological variation in serum ACE and CPN/CPB2 activity in healthy individuals as measured by the degradation of dabsylated bradykinin-reference data and the importance of pre-analytical standardization. Proteomes., 2025, 13(3): 40
|
| [23] |
Osterhus V, König S. Angiotensin-converting enzyme and blood basic carboxypeptidases CPB2 and CPN activity is an indicator for serum quality: a quick lab test. In: Renin-Angiotensin-Aldosterone System - Latest Trends. London: IntechOpen; 2024.
|
Funding
Universität Münster (1056)
RIGHTS & PERMISSIONS
The Author(s)
Just Accepted
This article has successfully passed peer review and final editorial review, and will soon enter typesetting, proofreading and other publishing processes. The currently displayed version is the accepted final manuscript. The officially published version will be updated with format, DOI and citation information upon launch. We recommend that you pay attention to subsequent journal notifications and preferentially cite the officially published version. Thank you for your support and cooperation.
PDF
