Response to Commentary: Memory B Cells in Major Depressive Disorder: Toward Mechanistic and Clinical Refinement

References

[1] Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron., 2020, 107(2): 234-256

[2] Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry., 2015, 172(11): 1075-1091

[3] Li R, Rezk A, Miyazaki Y, et al. . Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy. Sci Transl Med., 2015, 7(310): eaabb4176

[4] Cognasse F, Hamzeh-Cognasse H, Lafarge S, et al. . Identification of two subpopulations of purified human blood B cells, CD27^–?CD23⁺ and CD27^high?CD80⁺, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Immunology., 2008, 125(3): 430-437

[5] Duddy M, Niino M, Adatia F, et al. . Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol., 2007, 178(10): 6092-6099

[6] Si SM, Xin YY, Guan SD, et al. . Bidirectional Mendelian randomization and colocalization study of memory B cells and major depressive disorder. Curr Med Sci., 2026, 46(1): 264-273

[7] Grimsholm O. CD27 on human memory B cells–more than just a surface marker. Clin Exp Immunol., 2023, 213(2): 164-172

[8] Donnelly NA, Tsang RSM, Foley ÉM, et al. . Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults. Brain Behav Immun., 2025, 128: 673-684

[9] Dunjic-Kostic B, Ivkovic M, Radonjic NV, et al. . Melancholic and atypical major depression—Connection between cytokines, psychopathology and treatment. Prog Neuro Psychopharmacol Biol Psychiatry., 2013, 43: 1-6

[10] Karlović D, Serretti A, Vrkić N, et al. . Serum concentrations of CRP, IL-6, TNF-α and Cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Res., 2012, 198(1): 74-80

[11] Haapakoski R, Mathieu J, Ebmeier KP, et al. . Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun., 2015, 49: 206-215

RIGHTS & PERMISSIONS

The Author(s), under exclusive licence to the Huazhong University of Science and Technology

Just Accepted

This article has successfully passed peer review and final editorial review, and will soon enter typesetting, proofreading and other publishing processes. The currently displayed version is the accepted final manuscript. The officially published version will be updated with format, DOI and citation information upon launch. We recommend that you pay attention to subsequent journal notifications and preferentially cite the officially published version. Thank you for your support and cooperation.