Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions

Abstract

Trehalose, a naturally occurring disaccharide, is gaining recognition for its therapeutic potential across a wide range of disorders. This review highlights the increasing importance of trehalose in clinical research and its applications in disease management. The unique biochemical properties of trehalose, including its ability to increase stress resistance and protect cellular structures, make it a promising therapeutic agent for various pathological conditions. Trehalose has demonstrated potential in addressing metabolic disorders such as diabetes and obesity by regulating glucose homeostasis, improving insulin sensitivity, and modulating lipid metabolism. Additionally, it has shown promise in cancer treatment by inhibiting tumor growth and promoting cell death. Beneficial effects have also been observed in models of cardiovascular diseases, ocular and dental conditions, osteoarthritis, Niemann–Pick disease, and genetic disorders. While existing clinical studies provide valuable insights into the therapeutic potential of trehalose, further research is needed to optimize its dosage, elucidate its mechanisms of action, and conduct large-scale trials to establish its efficacy and safety. In conclusion, trehalose represents a promising therapeutic compound with broad applications, offering a compelling avenue for future research and the development of innovative treatment strategies.

Keywords

Trehalose / Dry eye syndrome / Obesity / Diabetes mellitus / Cardiovascular diseases / Niemann-Pick disease / Insulin resistance / Osteoarthritis

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