Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia: A Prospective, Randomized, Open, Parallel Controlled and Multicenter Clinical Study

Abstract

Objective

This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.

Methods

A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups. Patients in the control group were treated with polysaccharide-iron complex, and those in the experimental group were administered Jianpi Shengxue tablet. After 8 weeks of continuous treatment, the therapeutic outcomes regarding anemia were compared between the two groups.

Results

After treatment, the red blood cell (RBC) count, hematocrit (HCT), reticulocyte percentage (RET), ferritin (SF), serum iron (SI), transferrin saturation (TSAT), and serum albumin (ALB) all increased (P<0.01), and the clinical symptom score and total iron binding capacity decreased (P<0.01) in the experimental group. Moreover, the improvements in RBC, HCT, RET, SF, SI, TAST, ALB, and clinical symptoms (fatigue, anorexia, dull skin complexion, numbness of hands and feet) in the experimental group were significantly greater than those in the control group (P<0.05). The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group (P<0.01).

Conclusion

The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia, leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

References

[1] ErikssonD, GoldsmithD, TeitssonS, et al.. Cross-sectional survey in CKD patients across Europe describing the association between quality of life and anaemia. BMC Nephrol, 2016, 17(1): 1-10

[2] HoshinoJ, MuenzD, ZeeJ, et al.. Associations of hemoglobin levels with health-related quality of life, physical activity, and clinical outcomes in persons with stage 3–5 nondialysis CKD. J Ren Nutr, 2020, 30(5): 404-414

[3] ThorpML, JohnsonES, YangX, et al.. Effect of anaemia on mortality, cardiovascular hospitalizations and end-stage renal disease among patients with chronic kidney disease. Nephrology, 2009, 14(2): 240-246

[4] National Institute of Diabetes and Digestive and Kidney Diseases. Anemia in Chronic Kidney Disease ∣ NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2019. Available from: https://www.mddk.nih.gov/health-information/kidney-disease/anemia

[5] SuzukiM, HadaY, AkaishiM, et al.. Effects of anemia correction by erythropoiesis-stimulating agents on cardiovascular function in non-dialysis patients with chronic kidney disease. Int Heart J, 2012, 53(4): 238-243

[6] TsuruyaK, YoshidaH, SuehiroT, et al.. Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin. Ren Fail, 2016, 38(3): 390-396

[7] MuirheadN, CattranD C, ZaltzmanJ, et al.. Safety and efficacy of recombinant human erythropoietin in correcting the anemia of patients with chronic renal allograft dysfunction. J Am Soc Nephrol, 1994, 5(5): 1216-1222

[8] Working Group on Renal Anemia Guidelines of Nephrology Physician Branch of Chinese Medical Association. Clinical Practice Guidelines for Diagnosis and Treatment of Renal Anemia in China. Zhonghua Yixue Zazhi (Chinese), 2021, 101(20): 1463-1502

[9] LiJ, MaLL, JiY, et al.. Exploring the potential target of traditional Chinese medicine in the study of renal anemia from the new progress in the pathogenesis of renal anemia. Zhongguo Zhongxiyi Jiehe Zazhi (Chinese), 2021, 22(10): 932-934

[10] ZhaoP, LiuWW, ZhangL, et al.. Clinical study of Tiaogan decoction in treating renal anemia. Liaoning Zhongyi Zazhi (Chinese), 2016, 43(05): 985-987

[11] HuangW, RaoKL, YanZY, et al.. Effect of Shenshuai Prescription on Renal Anemia and Micro-inflammation in Patients with CKD in Stage 3–5. Shizhen Guoyi Guoyao (Chinese), 2023, 34(6): 1397-1399

[12] LiXL, ZhaoXL, WangYQ, et al.. Clinical observation on the treatment of renal anemia with Yishen Buqi Huoxue recipe plus traditional Chinese medicine enema combined with rHuEPO. Zhongchengyao (Chinese), 2011, 33(03): 390-392

[13] WuXM, DongYP, HeYC, et al.. The effect of Zishen Shengxue recipe on renal anemia in maintenance hemodialysis and its influence on iron metabolism and blood lipid. Hebei Zhongyiyao Xuebao (Chinese), 2022, 37(4): 44-47

[14] Yang FD, Li CY. Textual research on Codonopsis pilosula. Zhongguo Zhongyiyao Xinxi Zazhi (Chinese), 2007(2):100–101

[15] SunXS, XieB. Research progress on pharmacological effects of yam. Zhongyao Xinyao Yu Linchuang Yaoli (Chinese), 2011, 22(3): 353-355

[16] YuanCL, SunL, YuanST, et al.. Research progress on pharmacologicalactivity and mechanism of action of effective components of Ophiopogon japonics. Zhongguo Xinyao Zazhi, 2013, 22(21): 2496-2502(Chinese)

[17] WangBQ, GuoYL, LianYY, et al.. Research progress on c-hemical constituents and pharmacological effects of Endothelium Corneum Gigeria-e Galli. Anhui Nongye Kexue (Chinese), 2017, 45(33): 137-139

[18] ZhangH, ZhangL, LiuY. Comparative study on chemical constituents and pharmacological effects of Os Draconis and Oysters. Zhongguo Zhongyao Zazhi (Chinese), 2011, 36(13): 1839-1840

[19] YuXJ, ChenSH, LvGY. Overview of related research on the efficacy of “nourishing yin and tonifying kidney” of tortoise shell. Dangdai Yixue (Chinese), 2009, 15(10): 15-17

[20] LiangXQ, LiDD, HuangZW. Research progress on pharmacological effects of Poria cocos. Henan Keji Daxue Xuebao Yixueban (Chinese), 2012, 30(2): 154-156

[21] YangE, ZhongYM, FengYF. Research progress on chemical constituents and pharmacological effects of Atractylodes macrocephala. Guangdong Yaoxueyuan Xuebao (Chinese), 2012, 28(02): 218-221

[22] WangY, WangYZ, MaQL, et al.. Research progress of Endothelium Corneum Gigeriae Galli. Zhongguo Mingzu Mingjian Yiyao (Chinese), 2014, 23(19): 10-12

[23] LiuMX, QiJ, YuBY. Research progress on pharmacological effects of Codonopsis pilosula. Haixia Yaoxue (Chinese), 2018, 30(11): 36-39

[24] WeiHT, FangQH, ZhangBS, et al.. Research progress on effective components and pharmacological effects of Atractylodes macrocephala. Guangdong Xumu Shouyi Keji, 2022, 47(06): 40-44(Chinese)

[25] JiangX, SunSF, WangY, et al.. Research progress on pharmacological action of Glycyrrhiza uralensis Fisch. Huagong Shikan (Chinese), 2017, 31(7): 25-28

[26] LiB, GengG. Research progress on chemical constituents and pharmacological effects of Astragalus membranaceus. Zhongxiyi Jiehe Zazhi (Chinese), 2022, 14(04): 262-264

[27] LiuN, GaoCB, FuB. Changes in the application of calcined oysters in ancient and modern times. Linchuang Yiyao Wenxian Dianzi Zazhi (Chinese), 2017, 4(95): 18788-18790

[28] QiuM, XiongZK, LvMY. Research progress on pharmacological effects of jujube polysaccharide. Zhongguo Xiandai Yisheng (Chinese), 2018, 56(22): 161-164

[29] PanJZ, MengQL, CuiWY, et al.. Research progress on functional components and pharmacological effects of Chinese yam. Shipin Gongye Keji (Chinese), 2023, 44(01): 420-428

[30] TanTP, GuoX, WenY, et al.. Clinical application and research of Endothelium Corneum Gigeriae Galli. Zhongguo Zhongyiyao Keji (Chinese), 2023, 30(01): 205-207

[31] WangXY, TanXM, ZhangWX, et al.. Comparison of preventive and therapeutic effects of different dosage forms of vinegar tortoise shell on mice with blood deficiency or osteoporosis. Zhongguo Yaofang (Chinese), 2017, 28(19): 2661-2665

[32] LuoL, PeiG, LiQ, et al.. Research progress on chemical constituents and pharmacological effects of Liriope. Zhongguo Yaowu Jingjie (Chinese), 2010, 7(11): 681-683

[33] Kong YD. Study on the chemical constituents and liver-protecting activity of Schisandra chinensis polysaccharide before and after vinegar steaming. Guangdong Yaoke Daxue (Chinese), 2020. DOI:https://doi.org/10.27690/d.cnki.ggdyk.20010.000000000105