Methods, Mechanisms, and Application Prospects for Enhancing Extracellular Vesicle Uptake

Ying-peng Xu1(), Tao Jiang1, Xiao-fan Yang1(), Zhen-bing Chen1()

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Current Medical Science ›› 2024, Vol. 44 ›› Issue (2) : 247-260. DOI: 10.1007/s11596-024-2861-7

Methods, Mechanisms, and Application Prospects for Enhancing Extracellular Vesicle Uptake

  • Ying-peng Xu1(), Tao Jiang1, Xiao-fan Yang1(), Zhen-bing Chen1()
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Abstract

Abstract

Extracellular vesicles (EVs) are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity, natural functionality, and excellent biocompatibility. However, limitations such as low uptake efficiency, insufficient production, and inhomogeneous performance undermine their potential. To address these issues, numerous researchers have put forward various methods and applications for enhancing EV uptake in recent decades. In this review, we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV uptake. In addition, we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

Keywords

extracellular vesicles / exosomes / extracellular vesicle uptake / extracellular vesicle-based therapy

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Ying-peng Xu, Tao Jiang, Xiao-fan Yang, Zhen-bing Chen. Methods, Mechanisms, and Application Prospects for Enhancing Extracellular Vesicle Uptake. Current Medical Science, 2024, 44(2): 247‒260 https://doi.org/10.1007/s11596-024-2861-7

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