Microbiological Advances in Orthodontics: An Overview and Detailed Analysis of Temporary Anchorage Devices

Abstract

Dental biofilm is the initiating factor of oral diseases, such as periodontitis and caries. Orthodontic treatment could alter the microbiome structure balance, and increase the risk of such diseases. Furthermore, fixed appliances can induce temporary changes in the microbiome community, and the changes that clear aligners bring are smaller by comparison. Temporary anchorage devices (TADs) are skeletal anchorages that are widely used in orthodontic treatment. Microorganisms affect the occurrence and development of inflammation surrounding TADs. At present, existing researches have verified the existence of plaque biofilm on the surface of TADs, but the formation of plaque biofilm and plaque composition under different stable conditions have not been fully understood. The development of high-throughput sequencing, molecular biology experiments, and metabonomics have provided new research ideas to solve this problem. They can become an effective means to explore the microbiome surrounding TADs.

Keywords

orthodontics / microbiome / fixed appliances / temporary anchorage devices / next-generation sequencing

References

[1] ManuelliM, MarcolinaM, NardiN, et al.. Oral mucosal complications in orthodontic treatment. Minerva Stomatol, 2019, 68(2): 84-88

[2] MüllerLK, JungbauerG, JungbauerR, et al.. Biofilm and Orthodontic Therapy. Monogr Oral Sci, 2021, 29: 201-213

[3] YassirYA, McIntyreGT, BearnDR. Orthodontic treatment and root resorption: an overview of systematic reviews. Eur J Orthod, 2021, 43(4): 442-456

[4] FreitasAO, MarquezanM, Nojima MdaC, et al.. The influence of orthodontic fixed appliances on the oral microbiota: a systematic review. Dental Press J Orthod, 2014, 19(2): 46-55

[5] LuccheseA, BondemarkL, MarcolinaM, et al.. Changes in oral microbiota due to orthodontic appliances: a systematic review. J Oral Microbiol, 2018, 10(1): 1476645

[6] PapageorgiouSN, XavierGM, CobourneMT, et al.. Effect of orthodontic treatment on the subgingival microbiota: A systematic review and meta-analysis. Orthod Craniofac Res, 2018, 21(4): 175-185

[7] VerrusioC, Iorio-SicilianoV, BlasiA, et al.. The effect of orthodontic treatment on periodontal tissue inflammation: A systematic review. Quintessence Int, 2018, 49(1): 69-77

[8] AlfurijiS, AlhazmiN, AlhamlanN, et al.. The effect of orthodontic therapy on periodontal health: a review of the literature. Int J Dent, 2014, 2014: 585048

[9] PapadopoulosMA, PapageorgiouSN, ZogakisIP. Clinical effectiveness of orthodontic miniscrew implants: a meta-analysis. J Dent Res, 2011, 90(8): 969-976

[10] KnightR, VrbanacA, TaylorBC, et al.. Best practices for analysing microbiomes. Nat Rev Microbiol, 2018, 16(7): 410-422

[11] LiuYX, QinY, ChenT, et al.. A practical guide to amplicon and metagenomic analysis of microbiome data. Protein Cell, 2021, 12(5): 315-330

[12] WillisJR, GabaldonT. The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems. Microorganisms, 2020, 8(2): 308

[13] GuoR, LinY, ZhengY, et al.. The microbial changes in subgingival plaques of orthodontic patients: a systematic review and meta-analysis of clinical trials. BMC Oral Health, 2017, 17(1): 90

[14] KoopmanJE, van der KaaijNC, BuijsMJ, et al.. The Effect of Fixed Orthodontic Appliances and Fluoride Mouthwash on the Oral Microbiome of Adolescents — A Randomized Controlled Clinical Trial. PLoS One, 2015, 10(9): e0137318

[15] GuoR, LiuH, LiX, et al.. Subgingival Microbial Changes During the First 3 Months of Fixed Appliance Treatment in Female Adult Patients. Curr Microbiol, 2019, 76(2): 213-221

[16] KadoI, HisatsuneJ, TsurudaK, et al.. The impact of fixed orthodontic appliances on oral microbiome dynamics in Japanese patients. Sci Rep, 2020, 10(1): 21989

[17] WeirT. Clear aligners in orthodontic treatment. Aust Dent J, 2017, 62(Suppl1): 58-62

[18] LevriniL, ManganoA, MontanariP, et al.. Periodontal health status in patients treated with the Invisalign(®) system and fixed orthodontic appliances: A 3 months clinical and microbiological evaluation. Eur J Dent, 2015, 9(3): 404-410

[19] GuoR, ZhengY, LiuH, et al.. Profiling of subgingival plaque biofilm microbiota in female adult patients with clear aligners: a three-month prospective study. PeerJ, 2018, 6: e4207

[20] ZhaoR, HuangR, LongH, et al.. The dynamics of the oral microbiome and oral health among patients receiving clear aligner orthodontic treatment. Oral Dis, 2020, 26(2): 473-483

[21] Antoszewska-SmithJ, SarulM, LyczekJ, et al.. Effectiveness of orthodontic miniscrew implants in anchorage reinforcement during en-masse retraction: A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop, 2017, 151(3): 440-455

[22] AlharbiF, AlmuzianM, BearnD. Anchorage effectiveness of orthodontic miniscrews compared to headgear and transpalatal arches: a systematic review and meta-analysis. Acta Odontol Scand, 2019, 77(2): 88-98

[23] ChenYJ, ChangHH, LinHY, et al.. Stability of miniplates and miniscrews used for orthodontic anchorage: experience with 492 temporary anchorage devices. Clin Oral Implants Res, 2008, 19(11): 1188-1196

[24] LaiTT, ChenMH. Factors affecting the clinical success of orthodontic anchorage: Experience with 266 temporary anchorage devices. J Dent Sci, 2014, 9(1): 49-55

[25] PapageorgiouSN, ZogakisIP, PapadopoulosMA. Failure rates and associated risk factors of orthodontic miniscrew implants: a meta-analysis. Am J Orthod Dentofacial Orthop, 2012, 142(5): 577-595

[26] HongSB, KusnotoB, KimEJ, et al.. Prognostic factors associated with the success rates of posterior orthodontic miniscrew implants: A subgroup meta-analysis. Korean J Orthod, 2016, 46(2): 111-126

[27] MohammedH, WafaieK, RizkMZ, et al.. Role of anatomical sites and correlated risk factors on the survival of orthodontic miniscrew implants: a systematic review and meta-analysis. Prog Orthod, 2018, 19(1): 36

[28] AraghbidikashaniM, GolshahA, NikkerdarN, et al.. In-vitro impact of insertion angle on primary stability of miniscrews. Am J Orthod Dentofacial Orthop, 2016, 150(3): 436-443

[29] CrismaniAG, BertlMH, CelarAG, et al.. Miniscrews in orthodontic treatment: review and analysis of published clinical trials. Am J Orthod Dentofacial Orthop, 2010, 137(1): 108-113

[30] SharmaP, ValiathanA, SivakumarA. Success rate of microimplants in a university orthodontic clinic. ISRN Surg, 2011, 2011: 982671

[31] AlySA, AlyanD, FayedMS, et al.. Success rates and factors associated with failure of temporary anchorage devices: A prospective clinical trial. J Investig Clin Dent, 2018, 9(3): e12331

[32] BearnDR, AlharbiF. British Orthodontic Society national audit of temporary anchorage devices (TADs): report of the first thousand TADs placed. J Orthod, 2015, 42(3): 214-219

[33] AzeemM, SaleemMM, LiaquatA, et al.. Failure rates of mini-implants inserted in the retromolar area. Int Orthod, 2019, 17(1): 53-59

[34] ChopraSS, ChakranarayanA. Clinical evaluation of immediate loading of titanium orthodontic implants. Med J Armed Forces India, 2015, 71(2): 165-170

[35] HeW, ZhuH, LiuC. Profiles of inflammation factors and inflammatory pathways around the peri-miniscrew implant. Histol Histopathol, 2021, 36(9): 899-906

[36] AndrucioliMCD, MatsumotoMAN, FukadaSY, et al.. Quantification of pro-inflammatory cytokines and osteoclastogenesis markers in successful and failed orthodontic mini-implants. J Appl Oral Sci, 2019, 27: e20180476

[37] ApelS, ApelC, MoreaC, et al.. Microflora associated with successful and failed orthodontic mini-implants. Clin Oral Implants Res, 2009, 20(11): 1186-1190

[38] FerreiraNO, AndrucioliMCD, Nelson-FilhoP, et al.. Bacterial biofilm on successful and failed orthodontic mini-implants-a scanning electron microscopy study. Microsc Res Tech, 2015, 78(12): 1112-1116

[39] GarcezAS, BarrosLC, FernandesMRU, et al.. Fluorescence image and microbiological analysis of biofilm retained around healthy and inflamed orthodontic miniscrews. Photodiagnosis Photodyn Ther, 2020, 30: 101707

[40] NewmanMG, TakeiHH, KlokkevoldPR, et al.Carranza’s clinical periodontology, 2015Twelfth edn.St. Louis, MO, Saunders Elsevier

[41] LaosuwanK, EpasingheDJ, WuZ, et al.. Comparison of biofilm formation and migration of Streptococcus mutanson tooth roots and titanium miniscrews. Clin Exp Dent Res, 2018, 4(2): 40-47

[42] de FreitasAO, AlvianoCS, AlvianoDS, et al.. Microbial colonization in orthodontic mini-implants. Braz Dent J, 2012, 23(4): 422-427

[43] ProffP, SteinmetzI, BayerleinT, et al.. Bacterial colonisation of interior implant threads with and without sealing. Folia Morphologica, 2006, 65(1): 75-77

[44] SocranskySS, HaffajeeAD, CuginiMA, et al.. Microbial complexes in subgingival plaque. J Clin Periodontol, 1998, 25(2): 134-144

[45] LamontRJ, KooH, HajishengallisG. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol, 2018, 16(12): 745-759

[46] LafaurieGI, SabogalMA, CastilloDM, et al.. Microbiome and Microbial Biofilm Profiles of Peri-Implantitis: A Systematic Review. J Periodontol, 2017, 88(10): 1066-1089

[47] HeidCA, StevensJ, LivakKJ, et al.. Real time quantitative PCR. Genome Res, 1996, 6(10): 986-994

[48] GorisJ, KonstantinidisKT, KlappenbachJA, et al.. DNA-DNA hybridization values and their relationship to whole-genome sequence similarities. Int J Syst Evol Microbiol, 2007, 57: 81-91 Pt 1

[49] TortamanoA, DominguezGC, HaddadAC, et al.. Periodontopathogens around the surface of miniimplants removed from orthodontic patients. Angle Orthod, 2012, 82(4): 591-595

[50] AndrucioliMCD, MatsumotoMAN, SaraivaMCP, et al.. Successful and failed mini-implants: microbiological evaluation and quantification of bacterial endotoxin. J Appl Oral Sci, 2018, 26: e20170631

[51] KirstME, LiEC, AlfantB, et al.. Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis. Appl Environ Microbiol, 2015, 81(2): 783-793

[52] GencoRJ, LaMonteMJ, McSkimmingDI, et al.. The Subgingival Microbiome Relationship to Periodontal Disease in Older Women. J Dent Res, 2019, 98(9): 975-984

[53] ZhengH, XuL, WangZ, et al.. Subgingival microbiome in patients with healthy and ailing dental implants. Sci Rep, 2015, 5: 10948

[54] BarrosSP, WilliamsR, OffenbacherS, et al.. Gingival crevicular fluid as a source of biomarkers for periodontitis. Periodontol, 2016, 70(1): 53-64 2000

[55] MoghaddamSF, MohammadiA, BehroozianA. The effect of sandblasting and acid etching on survival rate of orthodontic miniscrews: a split-mouth randomized controlled trial. Prog Orthod, 2021, 22(1): 2

[56] ChoiSH, JangSH, ChaJY, et al.. Evaluation of the surface characteristics of anodic oxidized miniscrews and their impact on biomechanical stability: An experimental study in beagle dogs. Am J Orthod Dentofacial Orthop, 2016, 149(1): 31-38

[57] JangI, ChoiDS, LeeJK, et al.. Effect of drug-loaded TiO(2) nanotube arrays on osseointegration in an orthodontic miniscrew: an in-vivo pilot study. Biomed Microdevices, 2017, 19(4): 94

[58] MartinsBG, de MouraVS, FujiiDN, et al.. Photobiomodulation stimulates surrounding bone formation and increases stability of titanium alloy miniscrews in ovariectomized rats. Lasers Med Sci, 2022, 37(7): 2917-2924

[59] AlkanÖ, KayaY, YüksekE, et al.. Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turk J Orthod, 2021, 34(1): 26-30

[60] MichelogiannakisD, JabrL, BarmakAB, et al.. Influence of low-level-laser therapy on the stability of orthodontic mini-screw implants. A systematic review and meta-analysis. Eur J Orthod, 2022, 44(1): 11-21

[61] LerarioF, RoncatiM, GariffoA, et al.. Non-surgical periodontal treatment of peri-implant diseases with the adjunctive use of diode laser: preliminary clinical study. Lasers Med Sci, 2016, 31(1): 1-6

[62] UesugiS, KokaiS, KannoZ, et al.. Prognosis of primary and secondary insertions of orthodontic miniscrews: What we have learned from 500 implants. Am J Orthod Dentofacial Orthop, 2017, 152(2): 224-231