Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study

Abstract

Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography (PMMRA). However, in this emerging field, the number of suitable kinds of liquid is still very limited. The objective of this research is to compare MR images of oleic acid (OA) with paraffin oil (PO) in vitro and in ex situ animal hearts, in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA. In vitro, OA, PO and water (control) were introduced into three tubes separately and T₁weighted-spin echo (T₁w-SE) and T₂w-SE images were acquired on a 1.5T MR scanner. In the second experiment, OA and PO were injected into left coronary artery (LCA) and left ventricle (LV) of ex situ bovine hearts and their T₁w-SE, T₂w-SE, T₁w-multipoint Dixon (T₁w-mDixon) and 3DT₂w-mDixon images were acquired. The overall results indicate that OA may have a potential to be used as a dual (T₁ and T₂ based) contrast agent for PMMRA when proper sequence parameters are utilized. However, as the pilot study was based on limited number of animal hearts, more researches using OA in cadavers are needed to validate our findings.

Keywords

postmortem magnetic resonance angiography / perfusate / contrast agent / oleic acid / paraffin oil / heart

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