Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis

Abstract

Cerebellar degeneration-related antigen 1 (CDR1) was described to be expressed in the nervous system and in different types of cancer tissues. In the present study, we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis, dermis and isolated skin cells. Both CDR1 mRNA and protein were detected in human skin-derived mast cells, melanocytes, fibroblasts and keratinocytes, suggesting that CDR1 does not have a neuron-specific function.

Keywords

cerebellar degeneration-related antigen 1 / skin / keratinocyte / mast cell

References

[1] DropchoEJ, ChenYT, PosnerJB, et al.. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci, 1987, 84(13): 4552-4556

[2] BoscoP, SpadaR, CanigliaS, et al.. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in Alzheimer’s disease. Neurol Sci, 2014, 35(10): 1613

[3] SalemiM, FraggettaF, GaliaA, et al.. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in prostate cancer cell lines. Int J Biol Markers, 2013, 29(3): e288-e290

[4] ChenYT, RettigWJ, YenamandraAK, et al.. Cerebellar degeneration-related antigen: a highly conserved neuro-ectodermal marker mapped to chromosomes X in human and mouse. Proc Natl Acad Sci, 1990, 87(8): 3077-3081

[5] FurneauxHM, DropchoEJ, BarbutD, et al.. Characterization of a cDNA encoding a 34-kDa Purkinje neuron protein recognized by sera from patients with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci, 1989, 86(8): 2873-2877

[6] EckertRL, GreenH. Structure and evolution of the human involucrin gene. Cell, 1986, 46(4): 583-589