Polysubstituted Phenyl Glucosides Produced by the Fungus Metarrhizium anisopliae

Abstract

Metarhizosides A–G (1–7), seven new polysubstituted phenyl glucosides, were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae. Compounds 1–7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4′-O-methyl-β-D-glucopyranose. Their structures were elucidated by NMR spectroscopy and chemical method. These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.

Keywords

marine-derived fungus / glucosides / Metarrhizium anisopliae / anti-inflammation / cytotoxicities

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