Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis

Abstract

Previous studies suggested an association between the EGF +61 A>G polymorphism and susceptibility to gastric cancer, but the results have been inconsistent. To draw a more precise risk estimation of the association, we performed a meta-analysis of published studies. PubMed, EMBASE, Google Scholar and the Chinese Wanfang databases were systematically searched to identify relevant studies. There were 7 studies involving 1992 cases of gastric cancer and 3202 controls in this meta-analysis. Our study showed that, overall, the EGF +61 A>G polymorphism was significantly associated with the increased risk of gastric cancer in allele model (G vs. A: OR=1.18, 95% CI=1.00–1.39), dominant model (GG + GA vs. AA: OR=1.28, 95% CI=1.05–1.55), homozygous model (GG vs. AA: OR=1.31, 95% CI=1.06–1.63) and heterozygous model (GA vs. AA: OR=1.25, 95% CI=1.01–1.53). The stratified analysis by ethnicity revealed a significant association between EGF +61 A>G polymorphism and gastric cancer risks in Asians. This meta-analysis indicates that EGF +61 A>G polymorphism may increase the risk of gastric cancer, especially in Asians. Large-sized, well-designed studies involving different ethnic groups should be conducted to confirm this association.

Keywords

EGF / gastric cancer / polymorphism / meta-analysis

References

[1] FerlayJ, SoerjomataramI, DikshitR, et al. . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2014, 136(5): E359-E386 PMID: 25220842

[2] BornscheinJ, MalfertheinerP. Helicobacter pylori and gastric cancer. Dig Dis, 2014, 32(3): 249-264 PMID: 24732191

[3] GonzálezCA, PeraG, AgudoA, et al. . Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer, 2003, 107(4): 629-634 PMID: 14520702

[4] DuellEJ, TravierN, Lujan-BarrosoL, et al. . Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 2011, 94(5): 1266-1275 PMID: 21993435

[5] ZhuH, YangX, ZhangC, et al. . Red and processed meat intake is associated with higher gastric cancer risk: a meta-analysis of epidemiological observational studies. PLoS One, 2013, 8(8): e70955 PMCID: 3743884 PMID: 23967140

[6] D’EliaL, GallettiF, StrazzulloP. Dietary salt intake and risk of gastric cancer. Cancer Treat Res, 2014, 159: 83-95 PMID: 24114476

[7] SaekiN, OnoH, SakamotoH, et al. . Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci, 2013, 104(1): 1-8 PMID: 23057512

[8] DongLM, PotterJD, WhiteE, et al. . Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA, 2008, 299(20): 2423-2436 PMCID: 2772197 PMID: 18505952

[9] McLeanMH, El-OmarEM. Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol, 2014, 11(11): 664-674 PMID: 25134511

[10] ZengF, HarrisRC. Epidermal growth factor, from gene organization to bedside. Semin Cell Dev Biol, 2014, 28: 2-11 PMID: 24513230

[11] LaurenceDJ, GustersonBA. The epidermal growth factor. A review of structural and functional relationships in the normal organism and in cancer cells. Tumour Biol, 1990, 11(5): 229-261 PMID: 2203137

[12] CarpenterG, CohenS. Epidermal growth factor. J Biol Chem, 1990, 265(14): 7709-7712 PMID: 2186024

[13] YamadaA, SaitoN, KameokaS, et al. . Clinical significance of epidermal growth factor (EGF) expression in gastric cancer. Hepatogastroenterology, 2007, 54(76): 1049-1052 PMID: 17629036

[14] CostaBM, FerreiraP, CostaS, et al. . Association between functional EGF +61 polymorphism and glioma risk. Clin Cancer Res, 2007, 13(9): 2621-2626 PMID: 17473192

[15] LinL, LiG, ZhangZ, et al. . Association of epidermal growth factor +61 A/G polymorphism in Chinese patients with colon cancer. Genet Test Mol Biomarkers, 2012, 16(9): 1142-1145 PMID: 22621366

[16] Abu-DayyehBK, YangM, FuchsBC, et al. . A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology, 2011, 141(1): 141-149 PMID: 21440548

[17] HamaiY, MatsumuraS, MatsusakiK, et al. . A single nucleotide polymorphism in the 5’ untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. Pathobiology, 2005, 72(3): 133-138 PMID: 15860930

[18] AraújoAP, CostaBM, Pinto-CorreiaAL, et al. . Association between EGF +61A/G polymorphism and gastric cancer in Caucasians. World J Gastroenterol, 2011, 17(4): 488-492 PMCID: 3027015 PMID: 21274378

[19] LinX, WuG, FuJ. The relationship between EGF 61G/A Polymorphisms and gastric cancer risk. Med Front, 2012231-232

[20] ZhanZ, ChenY, WuJ, et al. . Functional epidermal growth factor gene polymorphisms and risk of gastric cancer. Oncol Lett, 2013, 5(2): 631-636 PMCID: 3573096 PMID: 23420566

[21] GotoY, AndoT, GotoH, et al. . No association between EGF gene polymorphism and gastric cancer. Cancer Epidemiol Biomarkers Prev, 2005, 14(10): 2454-2456 PMID: 16214932

[22] YangG, RaoL, TianL, et al. . An association between EGF and EGFR gene polymorphisms with gastric cancer in a Chinese Han population. Hepatogastroenterology, 2012, 59(120): 2668-2671 PMID: 22534548

[23] JinG, MiaoR, DengY, et al. . Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population. Cancer Sci, 2007, 98(6): 864-868 PMID: 17433039

[24] PiaoY, LiuZ, DingZ, et al. . EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis. Gene, 2013, 519(1): 26-33 PMID: 23403233

[25] WangJ, DongW, GuoX, et al. . Association between polymorphisms of epidermal growth factor 61 and susceptibility of gastric cancer: A Meta-analysis. Chin J Cancer Prev Treat, 2014, 21(2): 150-153

[26] LiTF, RenKW, LiuPF. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol, 2012, 31(4): 568-574 PMID: 22070650

[27] ZhangYM, CaoC, LiangK. Genetic polymorphism of epidermal growth factor 61A>G and and cancer risk: a meta-analysis. Cancer Epidemiol, 2010, 34(2): 150-156 PMID: 20207214

[28] XuW, LiY, WangX, et al. . Association between EGF promoter polymorphisms and cancer risk: a meta-analysis. Med Oncol, 2010, 27(4): 1389-1397 PMID: 20033794

[29] StangA. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605 PMID: 20652370

[30] HigginsJP, ThompsonSG, DeeksJJ, et al. . Measuring inconsistency in meta-analyses. BMJ, 2003, 327(7414): 557-560 PMCID: 192859 PMID: 12958120

[31] HigginsJP, ThompsonSG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558 PMID: 12111919

[32] MantelN, HaenszelW. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748 PMID: 13655060

[33] Der SimonianR, LairdN. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177-188

[34] EggerM, Davey-SmithG, SchneiderM, et al. . Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634 PMCID: 2127453 PMID: 9310563

[35] ZhangJ, ZhanZ, WuJ, et al. . Relationship between EGF, TGFA, and EGFR gene polymorphisms and traditional Chinese medicine ZHENG in gastric cancer. Evid Based Complement Alternat Med, 2013, 2013: 1-13

[36] CacinaC, ArikanS, DuzkoyluY, et al. . Investigation of EGF A61G gene variation and serum EGF level on gastric cancer susceptibility and clinicopathological parameters[ abstract]. FEBS J, 2014, 281: 75-75

[37] KobayashiD, NomotoS, KoderaY, et al. . Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis. World J Surg, 2012, 36(2): 362-372 PMID: 22127425

[38] KangC, SongJJ, LeeJ, et al. . Epigenetics: an emerging player in gastric cancer. World J Gastroenterol, 2014, 20(21): 6433-6447 PMCID: 4047329 PMID: 24914365

[39] OkudaT, OndaM, TokunagaA, et al. . Stimulatory effect of EGF and inhibitory effect of sialoadenectomy on growth of an EGF receptor-hyperproducinghuman gastric cancer xenograft in nude mice. Surg Today, 1994, 24(8): 725-733 PMID: 7981544

[40] YasuiW, TakekuraN, KamedaT, et al. . Effect of epidermal growth factor on rat stomach carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine. Acta Pathol Jpn, 1990, 40(3): 165-171 PMID: 2360455

[41] HensonES, GibsonSB. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal, 2006, 18(12): 2089-2097 PMID: 16815674