In vivo testing of canine prosthetic femoral components with HA-Ti ladder-type coating on vacuum plasma-sprayed Ti substrate

Abstract

The purpose of the present study was to observe the structure and functional change of the bone-coating-prosthesis interface in vivo and to evaluate the histocompatibility of self-made prosthetic femoral components in the body and the degree of their bonding with the surrounding bone tissues as well as their stability. Six mature beagle dogs underwent bilateral hip replacement with prosthetic femur components. Three groups were established in terms of different coating of prothesis (four joints in each group): atmosphere (A) plasma-sprayed pure titanium (Ti) prosthetic joint with hydroxyapatite (HA) coating (HA+Ti+A group); vacuum (V) plasma-sprayed pure Ti prosthetic joint with HA coating (HA+Ti+V group); vacuum plasma-sprayed pure Ti prosthetic joint with Ti-HA stepped coating (Ti+HAG+Ti+V group). The hip joints were functionally evaluated, and subjected to X-ray examination, biomechanics inspection, and histological examination. As a result, X-ray imaging revealed all prosthetic joints were in a good location and no dislocation of joint was found. Shear strength of interface was significantly higher in Ti+HAG+Ti+V group than in HA+Ti+V group (P<0.05) and HA+Ti+A group (P<0.05) at 28th week. Histological examination showed the amount of newborn bone in Ti+HAG+Ti+V group was more than in HA+Ti+V group and HA+Ti+A group after 28 weeks. It was suggested that vacuum plasma-sprayed pure Ti prosthetic joint with TI-HA stepped coating could improve the bonding capacity of bone-prosthesis, enhance the stability of prosthesis, and increase the fixion of prosthetic femoral components because of better bone growth. This new type of biological material in prosthetic femoral components holds promises for application in clinical practice.

Keywords

hydroxyapatite / titanium / ladder-type coating / hip prosthesis / bone interface

References

[1] SchurmanDJ, SmithRL. Osteoarthritis: current treatment and future prospects for surgical, medical, and biologic intervention. Clin Orthop Relat Res, 2004S183-S189

[2] SoeverLJ, MackayC, SaryeddineT, et al.. Educational needs of patients undergoing total joint arthroplasty. Physiother Can, 2010, 62(3): 206-214

[3] KovacevicD, MariscalcoM, GoodwinRC. Injuries about the hip in the adolescent athlete. Sports Med Arthrosc, 2011, 19(1): 64-74

[4] LiZ, KawashitaM. Current progress in inorganic artificial biomaterials. J Artif Organs, 2011, 14(3): 163-170

[5] WangR, GaoY, YangS, et al.. Titanium alloy cage implantation for the treatment of ischemic necrosis of femoral head in dogs. J Huazhong Univ Sci Technol [Med Sci], 2008, 28(2): 163-166

[6] MatsumuraK, HayamiT, HyonSH, et al.. Control of proliferation and differentiation of osteoblasts on apatite-coated poly(vinyl alcohol) hydrogel as an artificial articular cartilage material.. J Biomed Mater Res A, 2010, 92(4): 1225-1232

[7] GaletzMC, FleischmannEW, KonradCH, et al.. Abrasion resistance of oxidized zirconium in comparison with CoCrMo and titanium nitride coatings for artificial knee joints. J Biomed Mater Res B Appl Biomater, 2010, 93(1): 244-251

[8] KyomotoM, MoroT, SaigaK, et al.. Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. Biomaterials, 2010, 31(4): 658-668

[9] ZupancicR, LegatA, FundukN. Tensile strength and corrosion resistance of brazed and laser-welded cobalt-chromium alloy joints. J Prosthet Dent, 2006, 96(4): 273-282

[10] KressAM, SchmidtR, HolzwarthU, et al.. Excellent results with cementless total hip arthroplasty and alumina-on-alumina pairing: minimum ten-year follow-up. Int Orthop, 2011, 35(2): 195-200

[11] GaleLR, ChenY, HillsBA, et al.. Boundary lubrication of joints: characterization of surface-active phospholipids found on retrieved implants. Acta Orthop, 2007, 78(3): 309-314

[12] LindsayW, BigsbyE, BannisterG. Prevention of infection in orthopaedic joint replacement. J Perioper Pract, 2011, 21(6): 206-209

[13] CataldoMA, PetrosilloN, CiprianiM, et al.. Prosthetic joint infection: recent developments in diagnosis and management. J Infect, 2010, 61(6): 443-448

[14] YanCH, ChiuKY, NgTP, et al.. Revision total hip arthroplasty with femoral impaction bone grafting. J Orthop Surg (Hong Kong), 2010, 18(3): 303-308

[15] KhanujaHS, VakilJJ, GoddardMS, et al.. Cementless femoral fixation in total hip arthroplasty. J Bone Joint Surg Am, 2011, 93(5): 500-509

[16] ChoJH, GarinoJP, ChooSK, et al.. Seven-year results of a tapered, titanium, hydroxyapatite-coated cementless femoral stem in primary total hip arthroplasty. Clin Orthop Surg, 2010, 2(4): 214-220

[17] GoodmanSB, OhKJ, ImrieS, et al.. Revision total hip arthroplasty in juvenile chronic arthritis: 17 revisions in 11 patients followed for 4–12 years. Acta Orthop, 2006, 77(2): 242-250

[18] BiemondJE, PakvisDF, van HellemondtGG, et al.. Long-term survivorship analysis of the cementless Spotorno femoral component in patients less than 50 years of age. J Arthroplasty, 2011, 26(3): 386-390

[19] KimYH, KimJS, OhSH, et al.. Comparison of porous-coated titanium femoral stems with and without hydroxyapatite coating. J Bone Joint Surg Am, 2003, 85-A(9): 1682-1688

[20] BierbaumBE, ZeegenEN, DaytonMR. Hydroxyapatite coating on the femoral stem in primary total hip arthroplasty. Orthopedics, 2003, 26(9): 913-914

[21] ZengXL, LiJF, YangSH, et al.. Preparation of canine artificial femoral stem with HA-Ti ladder-type coating on plasma-sprayed pure Ti substrate and its performance evaluation. Appl Surf Sci, 2012, 258: 4489-4496

[22] PierannunziiLM. Thigh pain after total hip replacement: a pathophysiological review and a comprehensive classification. Orthopedics, 2008, 31(7): 691-699

[23] AamodtA, Lund-LarsenJ, EineJ, et al.. Changes in proximal femoral strain after insertion of uncemented standard and customised femoral stems. An experimental study in human femora. J Bone Joint Surg Br, 2001, 83(6): 921-929

[24] DraenertKD, DraenertYI, KrauspeR, et al.. Strain adaptive bone remodelling in total joint replacement. Clin Orthop Relat Res, 200512-27

[25] ScannellPT, PrendergastPJ. Cortical and interfacial bone changes around a non-cemented hip implant: simulations using a combined strain/damage remodelling algorithm. Med Eng Phys, 2009, 31(4): 477-488

[26] WanZ, DorrLD, WoodsomeT, et al.. Effect of stem stiffness and bone stiffness on bone remodeling in cemented total hip replacement. J Arthroplasty, 1999, 14(2): 149-158

[27] AjeeshM, FrancisBF, AnnieJ, et al.. Nano iron oxide-hydroxyapatite composite ceramics with enhanced radiopacity. J Mater Sci Mater Med, 2010, 21(5): 1427-1434

[28] LingX, ChenW, LiuS, et al.. Expression of TGF-beta in region of bone defect repaired by collagen/nano-beta-tricalcium phosphate composite artificial bone. J Huazhong Univ Sci Technol [Med Sci], 2003, 23(3): 302-305

[29] TeixeiraS, FernandesH, LeusinkA, et al.. In vivo evaluation of highly macroporous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res A, 2010, 93(2): 567-575

[30] YangCY, ChenCR, ChangE, et al.. Characteristics of hydroxyapatite coated titanium porous coatings on Ti-6Al-4V substrates by plasma sprayed method. J Biomed Mater Res B Appl Biomater, 2007, 82(2): 450-459

[31] SøballeK, OvergaardS, HansenES, et al.. A review of ceramic coatings for implant fixation. J Long Term Eff Med Implants, 1999, 9(1-2): 131-151

[32] LazarinisS, K RrholmJ, HailerNP. Effects of hydroxyapatite coating on survival of an uncemented femoral stem. Acta Orthop, 2011, 82(4): 399-404

[33] García-ReyE, García-CimbreloE, Cordero-AmpueroJ. Outcome of a hemispherical porous-coated acetabular component with a proximally hydroxyapatite-coated anatomical femoral component: a 12- to 15-year follow-up study. J Bone Joint Surg Br, 2009, 91(3): 327-332

[34] LachiewiczPF, SoileauES, BryantP. Second-generation proximally coated titanium femoral component: minimum 7-year results. Clin Orthop Relat Res, 2007, 465: 117-121

[35] MochidaY, BauerTW, AkisueT, et al.. Alendronate does not inhibit early bone apposition to hydroxyapatite-coated total joint implants: a preliminary study. J Bone Joint Surg Am, 2002, 84-A(2): 226-235

[36] Muirhead-AllwoodSK, SandifordN, SkinnerJA, et al.. Uncemented custom computer-assisted design and manufacture of hydroxyapatite-coated femoral components: survival at 10 to 17 years. J Bone Joint Surg Br, 2010, 92(8): 1079-1084

[37] KokuboT, KimHM, KawashitaM. Novel bioactive materials with different mechanical properties. Biomaterials, 2003, 24(13): 2161-2175

[38] ChangBS, LeeCK, HongKS, et al.. Osteoconduction at porous hydroxyapatite with various pore configurations. Biomaterials, 2000, 21(12): 1291-1298

[39] XueW, TaoS, LiuX, et al.. In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity. Biomaterials, 2004, 25(3): 415-421

[40] LeeBH, KimJK, KimYD, et al.. In vivo behavior and mechanical stability of surface-modified titanium implants by plasma spray coating and chemical treatments. J Biomed Mater Res A, 2004, 69(2): 279-285