Clinicopathological analysis of central and extraventricular neurocytoma: A report of 17 cases

Abstract

Neurocytoma, a rare brain tumor, is characterized by a mass located mainly in cerebral ventricles. It is prone to be misdiagnosed as oligodendroglioma or ependymoma due to their similar histopathological features in clinical practice. This study aimed to examine the clinicopathological features and differential diagnosis of central and extraventricular neurocytoma. The clinical and histopathological data of 17 patients (male: female=7:10; age: 4–41 years; mean age: 27.4 years) with central or extraventricular neurocytoma were retrospectively analyzed. These patients showed typical radiological, histopathological and immunohistochemical features of neurocytoma. The tumor tissue was found to be composed of small uniform cells with round nuclei and clear cytoplasm resembling that of oligodendroglioma and ependymoma. Immunohistochemistry revealed the tumor tissues were positive for neuronal markers such as synaptophysin (SYN) and neuronal nuclear antigen (NeuN). It was concluded histopathological features of neurocytoma overlaps with some tumors in the central neural system. Immunopositivity for SYN and NeuN can help differentially diagnose neurocytoma.

Keywords

central neurocytoma / extraventricular neurocytoma / histopathology / immunohistochemistry

References

[1] ChoudhariK.A., KaliaperumalC., JainA., et al.. Central neurocytoma: A multi-disciplinary review. Br J Neurosurg, 2009, 23(6): 585-595

[2] ZhangD., WenL., HenningT.D., et al.. Central neurocytoma: Clinical, pathological and neuroradio logical findings. Clin Radiol, 2006, 61(4): 348-357

[3] FurtadoA., ArantesM., SilvaR., et al.. Comprehensive review of extraventricular neurocytoma with report of two cases, and comparison with central neurocytoma. Clin Neuropathol, 2010, 29(3): 134-140

[4] ChouS., VarikattW., DexterM., et al.. Extraventricular neurocytoma with atypical features and ganglionic differentiation. J Clin Neurosci, 2010, 17(7): 920-922

[5] GiangasperoF., CenacchiG., LosiL., et al.. Extraventricular neoplasms with neurocytoma features: A clinicopathological study of 11 cases. Am J Surg Pathol, 1997, 21(2): 206-212

[6] BuccolieroA.M., CaldarellaA., AmmannatiF., et al.. Extraventricular neurocytoma: Morphological and immunohistochemical considerations on differential diagnosis. Pathol Res Pract, 2002, 198(9): 627-633

[7] YuenS.T., FungC.F., NgT.H., et al.. Central neurocytoma: Its differentiation from intraventricular oligodendro glioma. Childs Nerv Syst, 1992, 8(7): 383-388

[8] YouH., KimY.I., ImS.Y., et al.. Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma. J Neurooncol, 2005, 74(1): 1-8

[9] HassounJ., GambarelliD., GrisoliF., et al.. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol, 1982, 56(2): 151-156

[10] ChenC.L., GambarelliD., GrisoliF., et al.. Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg, 2008, 110(2): 129-136

[11] MnifI., ChakerM., DaoudE., et al.. Central neurocytoma: Three case reports. J Neuroradiol, 2008, 35(1): 56-59

[12] Jaiswal S, Vij M, Rajput D, et al. A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma. J Clin Neurosci, 2010 (epub).

[13] TownsendJ.J., SeamanJ.P.. Central neurocytoma—a rare benign intraventricular tumor. Acta Neuropathol, 1986, 71(1–2): 167-170

[14] SakuradaK., AkasakaM., KuchikiH., et al.. A rare case of extraventricular neurocytoma. Brain Tumor Pathol, 2007, 24(1): 19-23

[15] LimaiemF., BellilS., ChellyI., et al.. Extraventricular neurocytoma in a child mimicking oligodendroglioma: A diagnostic pitfall. Pathologica, 2009, 101(2): 105-107

[16] LeenstraJ.L., RodriguezF.J., FrechetteC.M., et al.. Central neurocytoma: Management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys, 2007, 67(4): 1145-1154

[17] KlysikM., GavitoJ., BomanD., et al.. Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimicker. Diagn Cytopathol, 2010, 38(3): 202-207

[18] KubotaT., HayashiM., KawanoH., et al.. Central neurocytoma: immunohistochemical and ultrastructural study. Acta Neuropathol, 1991, 81(4): 418-427

[19] RobbinsP., SegalA., NarulaS., et al.. Central neuro cytoma. A clinicopathological, immunohist ochemical and ultrastructural study of 7 cases. Pathol Res Pract, 1995, 191(2): 100-111

[20] IshiuchiS., NakazatoY., IinoM., et al.. In vitro neuronal and glial production and differentiation of human central neurocytoma cells. J Neurosci Res, 1998, 51(4): 526-535

[21] RychlyB., KalinaP., BelanV., et al.. Synaptophysin negative central neurocytoma. Bratisl Lek Listy, 2010, 111(1): 41-44

[22] SoylemezogluF., OnderS., TezelG.G., et al.. Neuronal nuclear antigen (NeuN): A new tool in the diagnosis of central neurocytoma. Pathol Res Pract, 2003, 199(7): 463-468

[23] KobayashiT.K., BambaM., UedaM., et al.. Cytologic diagnosis of central neurocytoma in intraoperative squash preparations: a report of 2 cases. Acta Cytol, 2010, 54(2): 209-213

[24] MutM., Guler-TezelG., LopesM.B., et al.. Challenging diagnosis: Oligodendroglioma versus extraventricular neurocytoma. Clin Neuropathol, 2005, 24(5): 225-229

[25] YangG.F., WuS.Y., ZhangL.J., et al.. Imaging findings of extraventricular neurocytoma: report of 3 cases and review of the literature. AJNR Am J Neuroradiol, 2009, 30(3): 581-585

[26] MoriguchiS., YamashitaA., MarutsukaK., et al.. Atypical extraventricular neurocytoma. Pathol Int, 2006, 56(1): 25-29

[27] MrakR.E., YasargilM.G., MohapatraG., et al.. Atypical extraventricular neurocytoma with oligodendrogliomalike spread and an unusual pattern of chromosome 1p and 19q loss. Hum Pathol, 2004, 35(9): 1156-1159

[28] KimC.Y., PaekS.H., JeongS.S., et al.. Gamma knife radiosurgery for central neurocytoma: primary and secondary treatment. Cancer, 2007, 110(10): 2276-2284