Expression of apoptosis related protein in skin lesions of lichen planus and its implication

Xu’e Chen; Yan Wu; Jiawen Li; Zhixiang Liu; Qing Yue; Houjun Liu

doi:10.1007/s11596-008-0328-x

Current Medical Science ›› 2008, Vol. 28 ›› Issue (3) : 349 DOI: 10.1007/s11596-008-0328-x

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Expression of apoptosis related protein in skin lesions of lichen planus and its implication

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Abstract

In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.

Keywords

Caspase-3 / Bax / lichen planus

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Xu’e Chen, Yan Wu, Jiawen Li, Zhixiang Liu, Qing Yue, Houjun Liu. Expression of apoptosis related protein in skin lesions of lichen planus and its implication. Current Medical Science, 2008, 28(3): 349 DOI:10.1007/s11596-008-0328-x

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[1]	SantoroA., MajoranaA., BardelliniE., et al.. NF-kappaB expression in oral and cutaneous lichen planus. J Pathol, 2003, 201(3): 466-472

[2]	MazzarellaN., FemianoF., GombosF., et al.. Matrix metalloproteinase gene expression in oral lichen planus: erosive vs. reticular forms. J Eur Acad Dermatol Venereol, 2006, 20(8): 953-957

[3]	NeppelbergE., JohannessenA. C., JonssonR., et al.. Apoptosis in oral lichen planus. Eur J Oral Sci, 2001, 109(5): 361-364

[4]	SugermanP. B., SavageN. W., WalshL. J., et al.. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med, 2002, 13(4): 350-365

[5]	ChenX. E., LiuZ. X., YueQ., et al.. The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication. J Huazhong Univ Sci Technol [Med Sci], 2007, 27(6): 739-741

[6]	SugermanP. B., SavageN. W., ZhouX., et al.. Oral lichen planus. Clin Dermatol, 2000, 18(5): 533-539

[7]	MarshmanE., OttewellP. D., PottenC. S., et al.. Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine. J Pathol, 2001, 195(3): 285-292

[8]	TandaN., MoriS., SaitoK., et al.. Expression of apoptotic signaling proteins in leukoplakia and oral lichen planus: quantitative and topographical studies. J Oral Pathol Med, 2000, 29(8): 385-393

[9]	Tobon-ArroyaveS. I., Villegas-AcostaF. A., Ruiz-RestrepoS. M., et al.. Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus. Oral Dis, 2004, 10(3): 173-178