Changes of TXA₂ and PGI₂ during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage

Abstract

In order to explore the changes and the roles of TXA₂ and PGI₂ during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage, 31 cases subject to craniotomy were divided into three groups: group A, 9 patients with postoperative hypertensive crisis; group B, 13 patients without postoperative hypertensive crisis; and group C, 9 patients without history of hypertension and hypertensive intracerebral hemorrhage. TXA₂, TXB₂, 6-keto-PGF1α and PGI₂ were measured after operation in the three groups respectively. The postoperative blood pressure in group A, including SBP and DBP, was elevated more obviously than that in the other two groups. TXA₂ and PGI₂ in group A were significantly higher than those in other two groups (P<0.01). Moreover, the ratio of TXB₂ to 6-keto-PGF1α in group A was significantly higher than that in other two groups (P<0.05). The increase of TXA₂ and the relative inadequacy of prostacyclin, especially 6-keto-PGF1α, may play roles in the postoperative hypertensive crisis. And the increased value of TXB₂ to 6-keto-PGF1α could provide the basis for diagnosis of postoperative hypertensive crisis.

Keywords

hypertensive intracerebral hemorrhage / hypertensive crisis / TXA₂ / PGI₂

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