The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

Xu’e Chen; Zhixiang Liu; Qing Yue; Houjun Liu; Yan Wu; Jiawen Li

doi:10.1007/s11596-007-0632-x

Current Medical Science ›› 2007, Vol. 27 ›› Issue (32) : 739 -741. DOI: 10.1007/s11596-007-0632-x

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The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

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Abstract

In order to investigate the role of TNF-and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.

Keywords

TNF-α / ICAM-1 / lichen planus

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Xu’e Chen, Zhixiang Liu, Qing Yue, Houjun Liu, Yan Wu, Jiawen Li. The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication. Current Medical Science, 2007, 27(32): 739-741 DOI:10.1007/s11596-007-0632-x

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[1]	Villarroel DorregoM., CorrentiM., DelgadoR., et al.. Oral lichen planus: immunohistology of mucosal lesions. J Oral Pathol Med, 2002, 31(7): 410-414

[2]	HirotaM., ItoT., OkudelaK., et al.. Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med, 2002, 31(4): 204-212

[3]	KastelanM., Prpic MassariL., GruberF., et al.. The role of perforin-mediated apoptosis in lichen planus lesions. Arch Dermatol Res, 2004, 296(5): 226-230

[4]	SklavounouA., ChrysomaliE., ScorilasA., et al.. TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation. J Oral Pathol Med, 2000, 29(8): 370-375

[5]	ThongprasomK., DhanuthaiK., SarideechaiqulW., et al.. Expression of TNF-alpha in oral lichen planus treated with fluocinolone acetonide 0.1%. J Oral Pathol Med, 2006, 35(3): 161-166

[6]	AckermannL., HarvimaI. T.. Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation is associated with expression of ICAM-1 in the epidermis. Arch Dermatol Res, 1998, 290(7): 353-359

[7]	KawaguchiM., MitsuhashiY., KondoS.. Overexpression of tumour necrosis factor-alpha-converting enzyme in psoriasis. Br J Dermatol, 2005, 152(50): 915-919