Effect of trace elements on retinopathy of prematurity

Abstract

The effect of the trace elements on retinopathy of prematurity (ROP) were studied. Thirty preterm infants who had potential high risk factors of ROP were selected as observation group and 18 normal infants as control groups. By using atom spectrophotometer, the contents of serum trace elements (Mg, Cu, Zn, Mn, Se) were measured and analyzed statistically. The contents of serum Zn, Cu and Se in observation group were 0.75±0.22, 0.41±0.20 and (134.07±71.57)×10⁻³ mg/L respectively, and 0.55±0.12, 0.65±0.194 and (202.92±44.71)×10⁻³ mg/L in control group respectively (P<0.01). The contents of Cu and Se were obviously lower and that of Zn higher in observation group than those in control group. The same results were obtained between the infants with ROP and controls (P<0.01). However, there was no significant difference in the contents of serum Mg and Mn between two groups (P>0.05). It was concluded that the contents of serum Cu and Se in preterm infants who had high risk factors of ROP were obviously lower than in the controls. The contents of serum Cu and Se in the ROP infants were also much lower while contents of Zn much higher. Attention should be paid to the detection of the trace elements in preterm infants in order to prevent the deficiencies of Cu and Se. Only in this way can we prevent the deficiencies of Cu and Se, so as to decrease the ROP risk factors and prevent the disease.

Keywords

trace element / retinopathy of prematurity

References

[1] TerryT. L.. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens I preliminary report. Am J Ophthalmol, 1942, 25: 203

[2] An international classification of retinopathy of prematurity. The committee for the classification of retinopathy of prematurity. Arch Ophthalmol, 1984, 1102: 1130-1134

[3] The international committee for the classification of the late stages of retinopathy of prematurity. An international classification of retinopathy of prematurity. Arch Ophthalmol, 1987, 105: 906-912

[4] WangW. J.. Retinopathy of prematurity. J Chin Fundus (Chinese), 1996, 12: 30-32

[5] PhelpsD. L.. Retinopathy of prematurity. Pediatr Res, 1995, 16: 50-56

[6] ZhouY. F.. Investigation on the related risk factors of retinopathy of prematurity. Chin Perinatal Period Med (Chinese), 2003, 6: 338-341

[7] CaddellJ. L.. Hypothesis: the possible role of magnesium and copper deficiency in retinopathy of prematurity. Magnes Res, 1995, 8(3): 261-270

[8] DarlwB A. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst Rev, 2003, 4: CD003312

[9] GathwaleG.. Selenium in the neonate. Indian J Pediatr, 2002, 69(5): 443-446

[10] PoppA.. Prospective biochemical study of the antioxidant defense capacity in retinopathy of prematurity. Orv Hetil, 1997, 138(4): 201-205

[11] XuM.. Dynamic observation on serum zinc in low birth weight infants. J Chin Pediatr (Chinese), 1997, 35: 206-208

[12] YangM. J., ShenY. H.. Contents of serum Zn and distribution of T subsets in newborns. J Newborns (Chinese), 2001, 16: 241-243

[13] SpiererA.. An increase in superoxide dismutase ameliorates oxygen-induced retina in transgenic mice. Eye, 2005, 19(1): 86-91