Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

Xiaoming Yin; Ling Tu; Huiqing Yang

doi:10.1007/s11596-007-0308-6

Current Medical Science ›› 2007, Vol. 27 ›› Issue (8) : 248 -251. DOI: 10.1007/s11596-007-0308-6

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Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

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Abstract

In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimulated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P<0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P<0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.

Keywords

obesity / adipocyte / adiponectin / simvastatin / interleukin-6

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Xiaoming Yin, Ling Tu, Huiqing Yang. Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes. Current Medical Science, 2007, 27(8): 248-251 DOI:10.1007/s11596-007-0308-6