Analysis of nine cases of acute thallium poisoning

Abstract

In this study nine cases of thallium poisoning in a series of homicidal poisoning were analyzed in order to provide more information concerning thallium poisoning. It was found that the most common clinical feature of thallium poisoning was peripheral neuropathy and paraesthesia was more common than amyasthenia. Understanding of these clinical characteristics of thallium poisoning was helpful to early identification and differential diagnosis. Since the early administration of Prussian Blue, as a specific antidote for thallium poisoning, can substantially improve the prognosis, it is of great importance to establish a correct and early diagnosis.

Keywords

thallium poisoning / forensic toxicology / preliminary diagnosis / initial symptom / differential diagnosis

References

[1] MoY. N., YangJ., LiF., et al.. Seven cases of chronic hidden thallium poisoning due to homicidal poisoning by thallium. Chin J Forensic Med (Chinese), 2001, 16: 233-235

[2] ChenZ. Y.. The inspiration of 3 cases of severe thallium poisoning. Chin J Ind Hyg Occup Dis (Chinese), 1997, 17: 188-189

[3] BiJ. Z., ZhouQ. B., LaiC., et al.. A report of a thallium poisoning peripheral neuropathy being misdiagnosed as Guillain-Barre syndrome. Chin J Neurol (Chinese), 2003, 36: 484

[4] RossiF., CazzolaM., De SantisD., et al.. Cardiovascular effects of thallium sulfate after intracerebroventricular administration in normotensive rats. Curr Ther Res, 1987, 42: 778-789

[5] MulkeyJ. P., OehmeF. W.. A review of thallium toxicity, Vet Hum Toxicol, 1993, 35: 445-453

[6] LangS. X., WangX. Q., RaoW. J.. Investigation of a acute thallium poisoning. Chin J Ind Hyg Occup Dis (Chinese), 1998, 16: 231

[7] Maurice V, Ropper AH. Adams and Victor’s Principles of Neurology, 7th ed, McGraw-Hill Companies, Inc. 2001.1380–1387, 1279

[8] AsburyA. K., CornblathD. R.. Assessment of current diagnostic criteria for Guillain-Barre syndrome. Ann Neurol, 1990, 27: s21-s24

[9] SrianujataS.. Lead—the toxic metal to stay with human. J Toxicol Sci, 1998, 23(s2): 237-240

[10] RatnaikeR. N.. Acute and chronic arsenic toxicity. Postgrad Med J, 2003, 79(933): 391-396

[11] HeF. S.. Chinese Occupational Medicine, 1999, Beijing, People Health Publisher (Chinese): 215-226