Experimental immune complex glomerulonephritis: Immunofluorescent, light and electron microscopic study

Xiong Mi; Peng Jie-qing; Wu Ren-liang; Liu Shao-chun; Huang Shou-zhen; Chen Chang-wei

doi:10.1007/BF02911617

Current Medical Science ›› 1986, Vol. 6 ›› Issue (1) : 43 -47. DOI: 10.1007/BF02911617

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Experimental immune complex glomerulonephritis: Immunofluorescent, light and electron microscopic study

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Abstract

Experimental immune complex glomerulonephritis induced with bovine serum albumin (BSA) or sheep serum (SS) was studied under immunofluorescent, light and electron microscope. Immunofluorescent study revealed fine and coarse granular immunofluorescent deposits along the glomerular basement membrane (GBM). Electron microscopic examination showed humps of electron-dense deposits in the spaces between the processes of the podocyte external to the GBM. Light microscopic examination showed acute proliferative glomerulonephritis. Taking human immune complex glomerulonephritis into account, the results of the present Study are of considerable significance to the further study of etiology, pathogenesis, pathological changes, clinical manifestations, prevention and treatment of glomerulonephritis. In addition, similar results were obtained by using either BSA or SS. Under ordinary conditions, it is suitable to use SS instead of BSA, because the former is easy to get and cheaper.

Keywords

experimental glomerulonephritis / immune complex disease / serum albumin

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Xiong Mi, Peng Jie-qing, Wu Ren-liang, Liu Shao-chun, Huang Shou-zhen, Chen Chang-wei. Experimental immune complex glomerulonephritis: Immunofluorescent, light and electron microscopic study. Current Medical Science, 1986, 6(1): 43-47 DOI:10.1007/BF02911617

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References

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[1]	MihatschMJ, ZollingerHU.. MihatschMJ, ZollingerHU. General pathogenesis of glomerulonephritis. Renal Pathology in Biopsy, 1978, Berlin, Springer-Verlag: 183-217

[2]	DarmadyEM, MacIverAG.. DarmadyEM, MacIverAG. Immunological basis of glomerular disease. Renal Pathology, 1980, London-Boston, Butterworths: 224-41

[3]	FishAJ, et al. . Acute serum sickness nephritis in the rabbit, an immune deposit disease. Am J Pathol, 1966, 49(6): 997-1013

[4]	DavisonAM, et al. . The role of the mesangial cell in proliferative glomerulonephritis. J Clin Pathol, 1973, 26: 198-208

[5]	BradfieldJWB, CattellV.. The mesangial cell in glomerulonephritis: I. Mechanisms of hypercellularity in experimental immune complex glomerulonephritis. Lab Invest, 1977, 36: 481-6

[6]	KoideH.. YoshitoshiY, UedaY. Alteration in chemical composition of glomerular basement membrane in experimental glomerulonephritis. Glomerulonephritis, 1979, Japan, Baltimore: 15-22